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Fakulteta za farmacijo, Ljubljana (FFALJ)
  • Bioapplication and activity of fullerenol C60(OH)24
    Injac, Rade ...
    Here we summarize current investigations about a relatively new group of compounds mainly composed of carbon atoms - fullerenes and their derivatives. One of the fundamental characteristics of ... fullerene is its ability to quench various free radicals, behaving as a ććfree radical spongećć. Moreover, the dual nature of fullerenes to act as either quenchers or generators of cell - damaging ROS could be exploited for development of cytoprotective agents on one side or cytotoxic anticancer/antimicrobial agents on the other. In addition, several derivatives have shown immunomodulating, neuroprotective andradioprotective effect. Fullerenes are hydrophobic molecules best dissolvedin organic solvents, so potential biomedical applications are restricted by their extremely poor solubility in polar solvents. One of the strategies for improving poor solubility is derivatization. Fullerenol C60(OH)24 is a water-soluble derivative of C60 with improved chemical properties and potential bioapplicability as a free radical scavenger in biological systems, in oxidative stress induced by xenobiotics or radioactive irradiations. However, solubility of C60(OH)24 in water (44 mg/l) is not satisfactory and presents a major drawback in its application as an organo-protector. Improvement of physicochemical characteristics of C60(OH)24 and chronic investigations on different animal models as well as in human trials are recommended for establishing its antioxidant effect.
    Vir: African journal of biotechnology [Elektronski vir]. - ISSN 1684-5315 (Vol. 7, no. 25, 2008, str. 4940-4950)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 2489713

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