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Kmetijski inštitut Slovenije, Ljubljana (KISLJ)
  • Binary toxin producing Clostridium difficile strains
    Rupnik, Maja, 1967- ; Grabnar, Miklavž ; Gerič Stare, Barbara
    Clostridium difficile produces three toxins, TcdA, TcdB and CDT. TcdA and TcdBare single-stranded molecules acting as glucosyltransferases specific for small GTPases. CDT is an actin specific ... ADP-ribosylating binary toxin characteristically composed of two independent components, enzymatic CDTa (48 kDa) and binding CDTb (99 kDa). The cdtA and cdtB genes were sequenced in two CDT-positive strains of C. difficile (CD 196 and 8864) and at least two CDT-negative strains with truncated form of binary toxin gencs are known (VPI 10463 and C difficile genome strain 630). The prevalence of binary toxin producing strains is estimated to be from 1.6% to 5.5%, although a much higherproportion has been reported in some studies. The role of the binary toxin as an additional virulence factor is discussed.
    Vir: Anaerobe. - ISSN 1075-9964 (Vol. 9, 2003, str. 289-294)
    Vrsta gradiva - članek, sestavni del
    Leto - 2003
    Jezik - angleški
    COBISS.SI-ID - 17722073

vir: Anaerobe. - ISSN 1075-9964 (Vol. 9, 2003, str. 289-294)

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