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  • Zapleti in zdravljenje bolnikov z esencialno trombocitemijo = Complications and treatment of essential thrombocythemia
    Podbregar, Matej ; Černelč, Peter
    Background. Essential thrombocythemia (b'T) is a chronic myeloproliferative disorders. Bleeding and thrombotic complications are the major causes of morbidity and mortality in the patients with ... thrombocythemia. The incidence ofthese hemostatic complications is unknown. Patients. To determine the incidence of hemostatic complications and the prophylactic role of acetylsalicylic acid in the treatment of ET we analysed 124 patients with ET treated at the Department of Haematology, from January 1989 to December 1997. The age of patients with ET ranged from IS to 87 years (mean 57. 7 years). Thepatients were followed up for a total of 310 years. Results. The average platelet count of patients with ET was 986.3+-476.2x10 9/L. Women showed a statistically significant correlation between platelet count and platelet function studies with 1O micromol/LADP(r=-0.373,p=0.019). Thrombembolic complications and haemorrhage were noticed in 31 of the 124 patients (25.0%). There were significantly more complications in 17 (18.9%) females than 14 (41.2%) males (p =0.09). At the time ET was established there were 14 complications in 13 male and 14 complications in 14 female (p < 0.04). During observation and treatment there were only 10 complicatiorcs, 5 in (5.5%) females and 5 (14.7%) males (p=0.25). There was no correlation between the incidence or type of complications and gender, age, platelet count, platelet function studies and type of treatment. Conclusions. The incidence of thrombotic and haemorrhagic complication in ET is not negligible, there for itneeds treatment.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 68, št. 6, 1999, str. 353-356)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10161369

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