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  • Novosti v procesu keratinizacije = Noveltyes in process of keratinization
    Kansky, Aleksej
    Background. Differentiation of human epidermal cells (keratinocytes) is a verycomplex process which includes 1. keratins, 2. desmosomes, 3. cornified cell envelop, 4. epidermal lipids as well as 5. ... the signaling system. Conclusions. Keratin are the main component of the cytoskeleton of keratinocyte, their structure is however altering from the basal up to cornified laver. A number of mutations affecting keratins K1, K2e, K5, K6a, K9, K10 and K14 have been recognized as causes of various hereditary disordersof keratinization. Desmosomes are in a broader sense coinvolved in the keratinization process. A normal structure and a normal process of breakdown are essential in the formation tge cornified layer. Certain disorders due to deficient desmosomes are included into hereditary disorders of keratinization. Cornified cell envelopes (CE) are essential for an appropriate function of the cornified layer. Mutations of loricin, one of the components of CE are responsible for the development of Vohwinkel's syndrome. Epidermal lipids are involved in the process of keratinization and are also essential for the barrier function. SImilar to keratins the lipida are also changing from polar to non-polar in the outer-most cornified layer. Signaling system is responsible for reception of signals at the cell-surface for the transmission through cytoplasm to the nucleus.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 68, supl. 2, dec. 1999, str. II-3-II-6)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10956249

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