Klinični vidiki lymske borelioze = Clinical features of Lyme borreliosis
Strle, Franc, 1949-
Lyme borreliosis is the most frequent tick-transmitted disease in Slovenia. When clinically completely expressed, tick bite is followed by a skin lesion, and later by heart, nervous system and joint ...involvement. Other tissues and organ systems may also be affected. Clinical signs depend partly on the species of the causative agent: Borrelia garinii is prone to affect the nervous system, B. afzelii is predominantly associated with skin affection, while B. burgdorferi sensu stricto, the only species causing the disease in America, is most commonly related with arthritis. The most frequent clinical sign of Lyme borreliosis is an enlarging skin lesion, named erythema migrans. It usually develops at the site of a tick bite, several days to weeks after the bite. Duration of an untreated skin lesion is a few weeks. Initially it ishomogenous and later on ring-like as a consequence of central clearing. Whentypical, it enables a reliable clinical diagnosis and consequently rational treatment. The fact that laboratory confirmation of borrelial infection is as a rule required for a reliable diagnosis, and that some manifestations of Lyme borreliosis are at least partly a consequence of the immunological mechanisms, point to the necessity of close collaboration between microbiologists, immunologists and clinicians.
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