Ocenitev primarne hemostaze z novim analizatorjrm trombocitne funkcije = The platelet function analyzer (PFA-100): a novel system for evaluation of primary haemostasis
Benedik-Dolničar, Majda ; Slavec, Breda
The PFA-100TM system provides an in-vitro method for measurement of platelet function in whole blood anticoagulated with sodium citrate. This system simulates primary hemostasis after cut of small ...vessel. The PFA-100TM is a microprocessor controlled instrument and it uses two disposable cartridges: a collagen/epinephrin (coll/epi) and collagen/ADP (coll/ADP). This causes adhesion and aggregation of platelets. The process culminates in the formationof a primary platelet plug and time which is necessary for this is called the closure time (CT). In this study we established normal reference ranges for a CT in 52 children and adoles- cents without bleeding disorders. The mean value with cartridge coll/epi was 119 and mean value +- 2 SD from 78 to 160 s, the mean value with cartridge coll/ADP was 90 and mean value +-2SD from 55 to 124s. In the group of 21 patients with von Willebrand disease (vWd)14 patients had prolonged CT with both cartridges, 5 only with cartridge coll/epi, one only with coll/ADP and one patient with mild form of vWd had normal CT with both cartridges. We established sensitivity of 86% for CT coll/epi and 81% for coll/ADP and specificity 98% for coll/epi and 91,8% for coll/ADP. Negative predictive value for coll/epi was 94,5% and for coll/ADP 89,6%; positive predictive value for coll/epi was 94,7% and for coll/ADP 100%.All patients with severe form of congenital disorders of platelet function, all patients with low number of platelets and the patient with uremia had prolonged CT but all patients with severe form of haemophilia A hadnormal CT. We can conclude that PFA-100TM system is very useful as a routine screening test for assessing primary haemostasis disorders.
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