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  • Monoklonski imunoglobulin nedoločenega pomena = Monoclonal gammopathy of undetermined significance
    Mlakar, Uroš, 1948- ; Preložnik Zupan, Irena, medicina
    Background. The term monoclonal gammopathy of undetermined significance (MGUS)denotes the presence of a monoclonal immunoglobulin in patients without evidence of multiple myeloma, macroglobulinaemia, ... amyloidosis or other relateddiseases. MGUS is quite frequent and its incidence is increasing. In addition to its common occurrence, its importance is obviously related to the fact that it may evolve toward multiple myeloma and related diseases. Methods.In the paper, we analysed the patients with MGUS who were diagnosed over a period of ten years at the Department of Haematology, University Medical Centre Ljubljana. The diagnostic criteria for MGUS were:serum monoclonal immunoglobulin <30 g/L, monoclonal immunoglobulin proteinuria<1g/day, bone marrow plasma cells,10%; absence of bone lesions, no symptoms of multiple myeloma or related diseases. Results. Over a period of 10years, MGUS was diagnosed in 196 patients. The number of cases increased steeply in the last years of the study period. The male-to-female ratio was 83:113. The median age of the patients was 68 years (range 31-87 yrs). The monoclonal immunoglobulin was IgG in 77%, IgA in 11%, IgM in 9% and pure Bence-Jones proteinuria in 1%. Two patients had biclonal and one three-clonal gammopathy. The median value of the monoclonal immunoglobulin was 10.5 g/L (range 2-30 g/L). Thirty-one per cent of the patients with monoclonal immunoglobulin in serum had free light chains in urine too. The median value of serum monoclonal immunoglobulin in this group was greater (13 g/L) comparedto the group without free light chains in urine (8.8 g/L). (Abstract truncated at 2000 characters.)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 11, nov. 2000, str. 753-756)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 12486105

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