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  • Bolnišnična poraba protimikrobnih zdravil za sistemsko zdravljenje v Sloveniji = Utilization review of systemic antimicrobials in Slovene hospitals
    Černelč, Silvije
    The use of systemic antiinfectives in all 28 Slovenian hospitals between 1983 and 1995 was investigated. The starting points important for understanding of the studies of drug utilization are first ... presented. For the study, the antininfectives were arranged according to the ATC drug classification and by their nonproprietary names. The analysis showed that the mean length of hospital stay was decreasing gradually from 12.7 days in 1983 to 10.4 days in 1995 (p < 0.001), and revealed significant differences in choice as well as infrequency of drug use in the study period. However, there was no increase inthe overall use of systemic antiinfectives in hospitals expressed as defineddaily doses per hundred bed days. The use of aminoglycosides was fairlyconstant, but there were changes in the relative use of different drugs.While the use of penicillins with (beta-lactamase inhibitors, cephalosporins, quinolones, macrolides, lincosamides, imipenem/cilastatin, vancomycin, metronidazole, antimycotics and antivirals increased significantly(p < 0.001), the use of tetracyclines, penicillins with extended spectrum, (beta-lactamase sensitive penicillins, sulphonamides and trimethoprim, drugs for treatment of tuberculosis and chloramphenicol, decreased significantly (p < 0.001). The antiinfective that showed the largestincrease in use was co-amoxiclav. Reasons for changes in the relative use of different groups of antiinfectives in Slovenian hospitals are most likely complex and would need further analysis, but they definitely mirror thefew data available from elsewhere in the world: microorganisms have become resistant, the number of patients with more serious infections has increased, combination therapy and perioperative antiinfective prophylaxis have become more widespread. The study of the rationality of drug utilization which may serve as the basis for planning, control, coordination, education and improvement of drug treatment was grounded.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 41, supl. 2, mar. 2002, str. 43-52)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - slovenski
    COBISS.SI-ID - 14729433

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 41, supl. 2, mar. 2002, str. 43-52)

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