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  • Radiochemotherapy for advanced head and neck carcinoma - Ljubljana experience = Kombinirano zdravljenje napredovalega karcinoma glave in vratu - ljubljanska izkušnja
    Šmid, Alojz, 1941- ...
    In prospectively designed randomized clinical trial the efficacy of simultaneous application of irradiation, Mitomycin C, and Bleomycin was tested. 64 patients with previously untreated, ... histologically confirmed inoperable squamous cell carcinoma of the head and neck region were randomly assigned to receive either radiation therapy alone (group A) or radiotherapy combined with simultaneous application of Mitomycin C and Bleomycin (group B).In patients with inoperable oropharyngeal carcinoma, the disease free survival was significantly better in combined radiochemotherapy group (48%) then in only irradiated patients (10%) (p=0.001). The same combination was later tested in 114 patients with advanced but still resectable disease in thehead and neck region as postoperative treatment. In prospective randomized clinical study, patients were treated postoperatively by irradiation alone (group A), or received postoperatively also concomitant chemotherapy (group B). At four years 1, in patients from radiochemotherapy group, locoregional control (86%) was significantly better than in radiotherapy group (57%) (p=0.037). Also, the overall survival for radiochemotherapy group was significantly better than for radiotherapy group (71% and 43% respectively) (p=0.036). From the subgroup analysis, it seems that the patients who benefited by chemotherapy were those with high risk factors. Proposed combinedtreatment scheme became in Slovenia the therapy of choice for patientswith inoperable oropharyngeal carcinoma as well as for patients operated for advanced but still resectable head and neck carcinoma with one ormore high risk factors.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, supl. 3, nov. 2002, str. III-81-III-84)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15698393

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