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  • Konkomitantna radiokemoterapija z mitomycinom C in cisplatinom pri neoperabilnem karcinomu glave in vratu : raziskava faze I-II = Concomitant radiochemotherapy with mitomycin C and cisplatin in inoperable carcinoma of the head and neck : phase I-II study
    Strojan, Primož ...
    The Purpose of Phase I-II study was to evaluate concomitant radiochemotherapy with mitomycin C and cisplatin in inoperable carcinoma of the head and neck. The patients were treated with conventional ... radiotherapy (35 x 2 Gy/day), mitomycin C (15 mg/mz IV, after 10 Gy) and cisplatin applied during the last 10 days of irradiation. The daily dose of cisplatin was esca lated from 10 mg/mz to 12 mg/m2 to 14 mg/mZ IV, in order to determine the maximum tolerated dose and maximum acceptable level of intensity of the regimen. Results: Six patients were treated at each dose level. Fourteen (78%) tumors were classified as T4 and 7 (39%) as N3. Dose-limiting toxicity was not recorded and the daily cisplatin dose of 14 mg/mz was chosen as the maximum tolerated dose. Disease-free survival at 12 months of follow up was 36% and the overall survival rate was 45%. Conclusion: The tested regimen was not associated with unacceptable toxicity and the survival results are encouraging enough to be tested in the continuation of phase II clinical study.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 3, maj 2004, str. 119-123)
    Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasle
    Leto - 2004
    Jezik - slovenski
    COBISS.SI-ID - 17834457

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 3, maj 2004, str. 119-123)

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