Razvoj cepiva proti raku = Development of a vaccine against cancers
Fleischmann, William Robert ; Wu, Tzu G.
A novel method for the development of a cancer vaccine has been developed, using mouse tumor model systems. This method involves the use of long-term (1 week) in vitro interferon treatment of ...parental cancer cells to create cancer vaccine cells. These cancer vaccine cells are then inactivated by irradiation and inoculated as a vaccine into mice. Vaccinated mice are activated to develop tumor immunity against the live parental tumor. Optimisation studies show that vaccine efficacy is dependent upon the interferon concentration to which the cancer vaccine cells are exposed, with 3,000 units/ml of interferon providing the most efficacious level of tumor immunity; upon the number of vaccine cells/vaccination, with 106 cells/vaccination providing the best levelof tumor immunity; and, upon the number of vaccinations, with 4 or more vaccinations providing significant tumor immunity. The tumor immunity developsas a true adaptive immune response, since it exhibits memory, ability to be boosted by a booster, ability to have a systemic effect and specificity for the type of tumor used as the vaccine. Cell types required for the development of tumor immunity include macrophages, CD8+ cells, NK cells and CD4+ cells, but not B cells. The method for cancer vaccine development has been applied to two other tumors in two different mouse strains, suggesting that it may be generally applicable. The cancer vaccine is able to cure tumor-bearing mice of their tumors as well as to prevent the development of tumors.
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