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Control of low-resolution scanning of ovarian tumor stromal compartmentElie, Nicolas ...The active search for markers of prognostic impact and therapeutic response isof crucial importance in oncology. The amount of stroma is a potential indicator with a significant impact on tumor ... growth. To solve the problems linked to tumor heterogeneity and, hence, of quantization at the microscopic level, we developed an image-analysis strategy dedicated to estimating the proportion of tumor connective tissue in whole histological sections at low resolution. 2,700-dot-per-inch numerical images were acquired with a calibrated slide scanner and automatically analyzed. We performed a quality control in order to evaluate the efficiency of the proposed method of analysisat the selected resolution. The point-counting method and the interactive drawing of stroma limits on equivalent mosaic microscopic images were "the gold standards." The proportions of stroma estimated on microscopic images (magnification with a 4x objective corresponding to 16,200 dots per inch) and on slide scanner images (2,700 dots per inch) through point countingstereology or manual delineation were equivalent (p < 0.0001). The results obtained through automatic image processing of scanner images were also close to the gold standard (95% correlation, p < 0.0001). The proposed method makes it possible to estimate the stroma amount of ovarian carcinomas in whole histological sections with a simple, fast, and low-cost acquisition device.Vir: Image analysis & stereology : official journal of the International Society for Stereology. - ISSN 1580-3139 (Vol. 24, no. 2, jun. 2005, str. 85-93)Vrsta gradiva - članek, sestavni delLeto - 2005Jezik - angleškiCOBISS.SI-ID - 20112089
Avtor
Elie, Nicolas |
Labiche, Alexandre |
Michels, Jean-Jacques |
Herlin, Paulette
Teme
Ovarian Neoplasms |
Image Processing, Computer-Assisted |
Microscopy, Electron, Scanning |
Stromal Cells |
Jajčnik, novotvorbe |
Mikroskopija elektronska, vrstična |
Slika, obdelava z računalnikom |
Stromalne celice |
jajčniki |
rak (medicina) |
stereologija
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vir: Image analysis & stereology : official journal of the International Society for Stereology. - ISSN 1580-3139 (Vol. 24, no. 2, jun. 2005, str. 85-93)
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Elie, Nicolas | ![]() |
Labiche, Alexandre | ![]() |
Michels, Jean-Jacques | ![]() |
Herlin, Paulette | ![]() |
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