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  • From endothelial dysfunction to hypertension = Od endotelijske disfunkcije do hipertenzije
    Žemva, Aleš, 1948- ; Benca, Maja
    By releasing a variety of relaxing and contracting factors, the endothelium regulates vascular tone and reactivity. Among these factors, nitric oxide (NO)is most frequently mentioned. NO is released ... in response to shear stress (produced by blood flow) and to activation of receptors. Basal generation of NO keeps the arterial circulation in an actively dilated state. NO is involvedin the antiatherosclerotic properties of the endothelium, inhibiting platelet-vessel wall interaction, endothelial permeability, and proliferation of vascular smooth muscle cells. The role of other putative relaxing factors is rarely mentioned. Prostacydin and a still-unidentified endothelium-derived hyperpolarizing factor may also be involved. Soon after the discovery of endothelium-derived relaxing factors, it became clear that endothelial cells can mediate contraction as well. Endothelium-derived contracting factors include endothelin-1, thromboxane A2 and prostaglandin H2, as well as components of the renin-angiotensin system, such as angiotensin II. Endothelial dysfunction contributes to the underlying disease process of a number of conditions, including arterial hypertension, hypercholesterolemia, atherosclerosis, diabetes mellitus, congestive heart failure, and pulmonary hypertension. Endothelial dysfunction can be improved by: 1. non-pharmacological intervention (smoking cessation, exercise, low-cholesteroldiet), 2. supplementation (l-arginine, antioxidants, estrogens), 3. medication (beta blockers, calcium channel bloclcers, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists).
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Vol. 3, iss. 2, 2006, str. 152-158)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 21965273

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