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  • Lysosomal proteolysis in inflammation = Lizosomalna proteoliza pri vnetju
    Lah Turnšek, Tamara ...
    Host response to pathogen invasion of gingiva involves the accumulation of neutrophils and macrophages at the site of acute inflammation, with the release, among other biological active molecules, of ... lysosomal proteolytic enzymes, including cathepsins G, D, B, L, H and possibly others. In addition,the expression of their endogenous inhibitors, produced locally or systemically, is altered resulting in an imbalance between proteinases and inhibitors. When the host proteolytic cascades are activated by the pathogens to their advantage, the disease becomes chronic, resulting in substantial lossof periodontal tissue and alveolar bone. Our investigations of patients with acute and chronic periodontitis have demonstrated that, as well as metalloproteinases, cysteine proteinases, cathepsine B, L and H and their endogenous inhibitors, such as tissue derived stefins A and B, cystatin C, kininogens, a variety of salivary cystatins (S, SN, SA) and alpha-2 marcroglobulin, play an active reole in the process. Biological components of the cysteine-dependent host proteolytic system, highly upregulated in inflamedtissue and secreted into gingival fluid, may provide a potential diagnostic tool for prognosis of advanced periodontitis. The inhibitors of cysteine proteinases may prove as therapeutic agents in later stages of the disease, possibly, applied in combination with inhibitorst of pathogenic agents.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 67, supl. 2, jun. 1998, str. II-29-II-32)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 7662297

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