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  • Autologous stem cell transplantation in the treatment of acute leukaemias = Avtologna transplantacija krvotvornih matičnih celic pri zdravljenju akutnih levkemij
    Labar, Boris
    Background. Autologous haematopoietic stem cell transplantation (ASCT) is increasingly performed for the treatment of acute leukaemias. In the period between 1988 and 1998, 57 ASCT in patients with ... acute myeloblastic leukaemia (AML) and 45 ASCT in patients with acute lymphoblastic leukaemia (ALL) have been performed. In 99 procedures the source of stem cells was bone marrow and in 3 procedures peripheral stem cells. Patients were prepared for transplantation with cyclophosphamide and total body irradiation or cyclophosphamide with high dose busulfan. Relapse rate in patients with AML infirst remission was 39% and 72% in patients treated in advanced disease. Relapse rate in patients with ALL in first remission was 45% and 65% in patients treated in advanced disease. Estimated leukaemia free long term survival is 56% for AML patients in first remission and 23% for patients with advanced disease. Estimated leukaemia free long term survival is 54% for ALL patients in first remission and 29% for patients with advanced disease. Conclusions. Autologous stem cell transplantation is effective and relative safe method of therapy for AML and ALL in first remission and results are approaching alografts. Relapse is still the major problem of autografting. Autologous stem cell transplantation is considered as routine treatment approach for adult patients with acute leukaemias in first remission and without matched family donor.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 67, supl. 1, maj 1998, str. I-9-I-10)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 7936729

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