Naše izkušnje s serološko diagnostiko toksoplazmoze v nosečnosti = Our experience in serologic diagnosis of toxoplasmosis in pregnancy
Reberšek Gorišek, Jelka ; Ogrizek-Pelkič, Ksenija
The intracellular parasite Toxoplasma gondii causes acute or chronic congenital or acquired infection, with or without symptoms. In healthy humans acute infection is asymptomatic, or with mild signs ...of disease. However, it represents a serious hazard for patients with deficient immune response, and in pregnancy as the fetus is at risk. As a ruel, latent infection does not menace the fetus. There are various clinical manifestations as well as consequences of congenital toxoplasmosis which are a results of acute infection in the mother. The risk of infection transmission depend smainly on the duration of pregnancy. Serologic screening of pregnant women offers the possibility of detecting fresh infections and of introducing treatment immediality. In Slovenia identification of specific IgG, IgM, IgM antibodies is the most frequent method of confirming the infection. A precise definition of whether the infection occurred before or after pregnancy is essential. In Maribor an advisory group has been formed which gives advice on the detection and treatment of toxoplasmosis in pregnancy. The experience of this group drewattention to the gravity of the problem of interpreting the results of serologic tests for toxoplasmosis in pregnancy, particularly due to the application of various serologic tests, different manufacturers, the varying course of serologic tests, the choice of cut-off values and the choice of the laboratory. The aurhors believe that the standardization of tests and procedures as well asthe seting of criteria for laboratory diagnosis of toxoplasmosis in Slovenia, and the introduction of new methods into routine diagnosis - particularly polymerase chain reaction - would contribute greatly to an easier interpretation of results and thus to the improvement ofdiagnosisregarding T., gondii infection.
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