Citokini v kliniki - koristna informacija ali podatek odveč = Cytokines in clinical application - usefull or useless information
Wraber-Herzog, Branka
Nearly all cells of multicellular organisms produce and secrete cytokines. These are soluble hormone-like glycoproteins which play a pivotal role in signatransduction among the cells, with emphatic ...importance to the immune system. Cytokines are part of the biological response to noxious agents. During the evolutionary process they developed as a part of the defence mechanisms against parasites, including bacteria and viruses. They act via complicated interactions known as the cytokine network. Their primary functionis the regulation of immune resonse from the beginning to the effectorphase. The main source of cytokines are immune cells. Antigen presenting cells produce proinflammatory cytokines which, besides their beneficial role in defence mechanisms, may cause tissue and organ damage to the host. APC also secrete regulatory cytokines, which are known to maintain the balance between Th1 and Th2 cytokines produced by activated T lymphocytes.This balance is essential for an efficient defence against noxiousagents. The alterations in Th1/Th2 balance often underlie the changes in immune system responses. Our experiences with measurement of cytokines in different diseases is that proinflammatory cytokine response in similar circumstances might be either eruptive or weak without knowing be either eruptive or weak without knowing the exact regulatory mechanisms. The same is observed in Th1/Th2 response. At the moment cytokines are the subject of many clinical investigations directed toward the possibilities of cytokine therapy,looking for appropriate markers of the diseases, and understanding theaction of the cytokine network in different pathological conditions.
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