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Solid cancer patients achieve adequate immunogenicity and low rate of severe adverse events after SARS-CoV-2 vaccinationJanžič, Urška, onkologinja ...Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment ... receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, after the first and second doses and 3 months after a complete primary course of vaccination. Results were compared with healthy controls. Results: Of 112 patients, the seroconversion rate was 96%. A significant reduction in antibody levels was observed 3 months after vaccination in patients receiving immune checkpoint inhibitors versus control participants (p < 0.001). Adverse events were mostly mild. Conclusion: Immunogenicity after mRNA-based vaccine in cancer patients is adequate but influenced by the type of anticancer therapy. Antibody levels decline after 3 months, and thus a third vaccination is warranted.Vir: Future oncology. - ISSN 1479-6694 (Vol. 18, no. 23, 2022, str. 2537–2550)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 111378179
Avtor
Janžič, Urška, onkologinja |
Bidovec, Urška |
Mohorčič, Katja, 1978- |
Mrak, Loredana |
Fokter Dovnik, Nina |
Ivanović, Marija, zdravnica |
Ravnik, Maja, 1975- |
Čakš, Marina |
Škof, Erik |
Debeljak, Jerneja |
Korošec, Peter, 1970- |
Rijavec, Matija
Teme
onkološko zdravljenje |
imunogenost |
osnovno cepljenje mRNA |
čvrsti tumorji |
anticancer treatment |
immunogenicity |
mRNA-based vaccination |
solid cancer
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Janžič, Urška, onkologinja | 51382 |
Bidovec, Urška | 25169 |
Mohorčič, Katja, 1978- | 30985 |
Mrak, Loredana | 54566 |
Fokter Dovnik, Nina | 37569 |
Ivanović, Marija, zdravnica | ![]() |
Ravnik, Maja, 1975- | 23787 |
Čakš, Marina | ![]() |
Škof, Erik | 24572 |
Debeljak, Jerneja | 51978 |
Korošec, Peter, 1970- | 22807 |
Rijavec, Matija | 29300 |
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