YouTube is one of the most popular online sources of information for patients. The purpose of the study is to analyze the quality of YouTube videos about the most commonly applied radionuclide ...treatments.
Related radionuclide therapy videos were searched on YouTube in October 2021. The quality of the videos was assessed by using the Journal of the American Medical Association (JAMA) benchmark criteria, the DISCERN Scale and the Global Quality Scale (GQS).
A total of 473 videos were assessed and 270 were included in the study according to inclusion and exclusion criteria. According to the GQS score, videos were categorized as high-quality (n:63, 23.33%), intermediate quality (n:118, 43.70%) and low-quality (n:89, 32.96 %) groups. The findings of our study showed that the highest number of video views and comments were in the low-quality group. In addition; the number of video likes, views and comments were the lowest in the high-quality video group. The most viewed and commented as well as most liked videos and the videos of highest video power index scores were nonphysician sourced videos. The most quality videos were the physician-sourced videos in terms of JAMA, DISCERN and GQS scores.
Although high-quality videos about radionuclide treatments on YouTube may enlighten and motivate patients positively; it should be kept in mind that improper information may also be uploaded to this platform. Under the guidance of the European Association of Nuclear Medicine, it is necessary to generate an official video in English with multilingual subtitles.
Radioactive iodine (RAI) therapy is a radionuclide treatment for hyperthyroidism and well-differentiated thyroid cancer. One of the most popular sources of information for patients on the internet is ...YouTube. This study aimed to examine the quality of videos about RAI treatment.
This cross-sectional study was performed by using videos in YouTube. The terms "radyoaktif iyot tedavisi" and "radioactive iodine treatment" were used to search related videos in June 2021. The quality of the videos was assessed by using the Journal of the American Medical Association (JAMA) benchmark criteria, the DISCERN scale, and the global quality scale (GQS).
Of the total 88 videos evaluated, 56 videos (30 in English, 26 in Turkish) were analyzed according to the inclusion and exclusion criteria. Seven (12.5%) videos were assigned to the high-quality group, 16 (28.58%) to the intermediate quality group, and 33 (58.92%) to the low quality group. The findings of this study showed that the most popular videos with the highest video power index (VPI) scores and the highest number of video likes and comments belonged to the intermediate quality group. Contrarily, popularity level, number of video likes, and number of video views were the lowest in the high-quality group. The analysis of video sources revealed that viewers most preferred non-physician-sourced videos, with average total views of 59307.80 standard deviation (SD): 122554.13. The most liked videos were non-physician-made videos, with average total likes of 424.35 (SD: 639.41). The mean VPI scores were the highest in non-physician-made videos, with 25.18 (SD: 25.69). The average JAMA (1.92, SD: 0.50), DISCERN (34.31, SD: 14.33), and GQS scores (2.61, SD: 0.99) were the highest in physician-made videos.
Although high-quality videos on YouTube may inform and encourage patients positively, unprofessional, incorrect, and incomplete information can be also uploaded on YouTube and may mislead patients.
Background/Aim. Gastric emptying (GE) scintigraphy provides a physiologic and noninvasive measurement of GE. Although GE scintigraphy has been standardized, preparing a meal is still complex and not ...practical in daily routine. The aim of the study was to prepare a simple, practical, and easily standardizable semisolid meal and investigate its role in estimating the GE function in of rabbits. Methods. In the first part of the study (basal condition), the mixture of the macroaggregated albumin (MAA) labeled with 37 MBq (1 mCi) of technetium-99m (99mTc) and 40 g of barium sulfate (1g/mL) was applied to animals via a nasogastric catheter. A series of images (frame/min, 60 min) in the anterior and posterior projections were dynamically acquired, and the motion was corrected after the radiopharmaceutical application. A few days later, the same rabbits were scanned under the same protocol after a 1 mg atropine injection to simulate gastroparesis condition. Eleven rabbits were included according to inclusion and exclusion criteria, and a total of twenty-two imaging data sets were analyzed for quantification. Results. In the basal study, total counts of the mixture decreased from 87,800.83 ? 12,622.76 to 42,733.14 ? 6,591.53 at 30 min and to 13,684.19 ? 1,774.90 at 60 min, and these decreases were statistically significant (p = 0.003). Emptying percentages were 51.39 ? 0.78% at 30 min and 84.32 ? 1.56 at 60 min and were statistically significant (p = 0.003). After intravascular atropine sulfate injection, total counts of the mixture decreased from 84,508.78 ? 11,871.48 to 64,995.18 ? 9,298 at 30 min and to 53,507.17 ? 7,258.98 at 60 min, and these decreases were statistically significant (p = 0.003). Emptying percentages were 23.10 ? 1.11% at 30 min and 36.63 ? 1.42 at 60 min and were statistically significant (p = 0.003). The difference between basal and post-atropine sulfate gastric emptying percentage at 30th (p = 0.003) and 60th (p = 0.003) min was statistically significant. Conclusion. The meal, used in this study, is non-nutrient, fatty-free, and semisolid and is easy to prepare and administer. Due to its semisolid nature, it offers a chance to evaluate the quantification of regional and total GE as well as the separate roles of the fundus and antrum.
Objectives: BioNTech (Pfizer) and CoronaVac (Sinovac) vaccines are two of the most administered coronavirus disease-2019 (COVID-19) vaccines worldwide. Vaccination against severe acute respiratory ...syndrome-coronavirus-2 has caused a diagnostic challenge in oncological 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) studies. The aim of our study was to evaluate the 18F-FDG PET/CT findings of the two most commonly administered vaccines worldwide. Methods: Patients over 18 years old who underwent 18F-FDG PET/CT for oncological purposes in our institution between January 13, 2021 and January 31, 2022, who received a single or second dose of the BioNTech or CoronaVac vaccines in the last two months, were included in the study. Descriptive analyses were presented as mean, standard deviation, frequency and ratio. Additionally, chi-square test was used to analyze categorical variables. Results: Ipsilateral deltoid muscle hypermetabolism was observed in 6.9% (n=15) and 14.3% (n=22) patients who received CoronaVac and BioNTech vaccines, respectively. Ipsilateral axillary lymph node hypermetabolism was observed in 11% (n=24) and 41.6% (n=64) patients who received CoronaVac and BioNTech vaccines, respectively. Synchronous deltoid muscle and axillary lymph node hypermetabolism was observed in 4.14% (n=9) and 12.33% (n=19) patients who received CoronaVac and BioNTech vaccines, respectively. Significant differences were detected between CoronaVac and BioNTech vaccines in terms of ipsilateral deltoid muscle hypermetabolism, ipsilateral axillary lymph node hypermetabolism and synchronous deltoid muscle and axillary lymph node hypermetabolism (p<0.05). Conclusion: COVID-19 vaccination may result in ipsilateral axillary lymph node hypermetabolism, ipsilateral deltoid muscle hypermetabolism, or synchronous deltoid muscle and axillary lymph node hypermetabolism with different frequencies depending on the type of vaccination. Although synchronous deltoid muscle and axillary lymph node hypermetabolism can reduce misinterpretation of 18F-FDG PET/CT, to avoid misinterpretation, it is important to question the vaccination history during ongoing COVID-19 vaccination process.
Background/Aim
Selective intraarterial radionuclide therapy (SIRT) with yttrium-90 (Y-90) resin microspheres presently has successful results in primary or metastatic inoperable liver tumors. This ...procedure, which is also known as radioembolisation, delivers high doses of radiation selectively to hepatic tumors while minimum healthy liver exposure. The aim of this study was to present our clinical experience of radiomicrosphere therapy for the treatment of patients with unresectable hepatocellular carcinoma (HCC).
Methods
We performed 40 Y-90 microsphere therapies in 28 patients (5 females, 23 males; mean age ± SD 48 ± 8) with HCC during the period from April 2008 through December 2016. Pretreatment Tc-99m microaggregated albumin (MAA) scintigraphy was performed to all patients in order to detect eligibility for SIRT. All patients had pre- and post-biochemical tests (hemogram and serologic tests) and imaging methods (CT or MRI or PET/CT) at regular intervals to detect any possible complication and determine response rates.
Results
The mean shunting to the lungs on MAA scan was 6.5% and the mean ± SD administered dose of Y-90 was 1.55 ± 0.32 GBq in all patients. The estimated doses to the target tumors, normal liver parenchyma and lungs were 105.7 ± 55.3, 25.5 ± 8.2 and 5.8 ± 1.7 Gy, respectively. No significant complication was observed during or early after (first week) the treatment procedure and it was well tolerated by all the patients. Only one patient developed a treatment-related gastroduodenal ulcer 3 weeks after the treatment. In control imaging tests (MRI or FDG PET/CT) performed 2.5 months after the treatment, we observed complete response in 2 (7%) patients, partial response in 10 (36%) patients, stable disease in 5 (18%) patients and progressive disease in 11 (39%) patients.
Conclusion
According to our clinical experience, we can conclude that Y-90 microsphere therapy is a safe and effective treatment option for the patients with unresectable HCC without any serious side effects.
Searching for online health information is a popular approach employed by patients to enhance their knowledge for their diseases. Recently developed AI chatbots are probably the easiest way in this ...regard. The purpose of the study is to analyze the reliability and readability of AI chatbot responses in terms of the most commonly applied radionuclide treatments in cancer patients.
Basic patient questions, thirty about RAI, PRRT and TARE treatments and twenty-nine about PSMA-TRT, were asked one by one to GPT-4 and Bard on January 2024. The reliability and readability of the responses were assessed by using DISCERN scale, Flesch Reading Ease(FRE) and Flesch-Kincaid Reading Grade Level(FKRGL).
The mean (SD) FKRGL scores for the responses of GPT-4 and Google Bard about RAI, PSMA-TRT, PRRT and TARE treatmens were 14.57 (1.19), 14.65 (1.38), 14.25 (1.10), 14.38 (1.2) and 11.49 (1.59), 12.42 (1.71), 11.35 (1.80), 13.01 (1.97), respectively. In terms of readability the FRKGL scores of the responses of GPT-4 and Google Bard about RAI, PSMA-TRT, PRRT and TARE treatments were above the general public reading grade level. The mean (SD) DISCERN scores assesses by nuclear medicine phsician for the responses of GPT-4 and Bard about RAI, PSMA-TRT, PRRT and TARE treatments were 47.86 (5.09), 48.48 (4.22), 46.76 (4.09), 48.33 (5.15) and 51.50 (5.64), 53.44 (5.42), 53 (6.36), 49.43 (5.32), respectively. Based on mean DISCERN scores, the reliability of the responses of GPT-4 and Google Bard about RAI, PSMA-TRT, PRRT, and TARE treatments ranged from fair to good. The inter-rater reliability correlation coefficient of DISCERN scores assessed by GPT-4, Bard and nuclear medicine physician for the responses of GPT-4 about RAI, PSMA-TRT, PRRT and TARE treatments were 0.512(95% CI 0.296: 0.704), 0.695(95% CI 0.518: 0.829), 0.687(95% CI 0.511: 0.823) and 0.649 (95% CI 0.462: 0.798), respectively (p < 0.01). The inter-rater reliability correlation coefficient of DISCERN scores assessed by GPT-4, Bard and nuclear medicine physician for the responses of Bard about RAI, PSMA-TRT, PRRT and TARE treatments were 0.753(95% CI 0.602: 0.863), 0.812(95% CI 0.686: 0.899), 0.804(95% CI 0.677: 0.894) and 0.671 (95% CI 0.489: 0.812), respectively (p < 0.01). The inter-rater reliability for the responses of Bard and GPT-4 about RAİ, PSMA-TRT, PRRT and TARE treatments were moderate to good. Further, consulting to the nuclear medicine physician was rarely emphasized both in GPT-4 and Google Bard and references were included in some responses of Google Bard, but there were no references in GPT-4.
Although the information provided by AI chatbots may be acceptable in medical terms, it can not be easy to read for the general public, which may prevent it from being understandable. Effective prompts using 'prompt engineering' may refine the responses in a more comprehensible manner. Since radionuclide treatments are specific to nuclear medicine expertise, nuclear medicine physician need to be stated as a consultant in responses in order to guide patients and caregivers to obtain accurate medical advice. Referencing is significant in terms of confidence and satisfaction of patients and caregivers seeking information.
Bee venom: A medical perspective SİG, Ali Korhan; GÜNEY, Mustafa; ÖZ SİG, Özlem ...
Turkish Journal of Clinics and Laboratory,
09/2019, Letnik:
10, Številka:
3
Journal Article
Recenzirano
Apitherapy
is a complementary medical technique that has an old history and is applied in
various diseases worldwide. Apitherapeutical applications are not treatment
methods by themself, but theycan ...be substantial parts of multidisciplinary
approaches. One of them, bee venom therapy, is a currently-applied method
worldwide. Bee venom (BV) includes several substances such as peptides, phospholipids,
bioactive amines, amino acids, sugars, pheromones, enzymes and minerals.Studies
on whole BV and its singular components indicated that they have a huge
potential in anti-inflammatory, anti-arthritis, anti-nociceptive,
neuroprotective, anti-tumoral, anti-microbial, anti-diabetic and anti-rheumatic
activities.Results of in vivo studies
against arthritis, Parkinson’s and Alzheimer’s disease andcancer are very
promising, and also in vitro results
indicating other activities such as antimicrobial effect are observed. Although
mechanisms of action and many bioactive substances still remains unclear,
beneficial effects and potential utilities in certain medical conditions are
obvious. It seems bioactive components of BV may open new doors in treatment of
various diseases.
Apiterapi,
dünya çapında çok sayıda hastalığın tedavisinde kullanılan ve kökeni çok eski
tıbbi kayıtlara dayanan bir tamamlayıcı tıp uygulamasıdır. Apiterapötik
teknikler kendi başlarına tedavi yöntemleri değil, aslında, çok disiplinli
tıbbi yaklaşımın bir parçasıdırlar. Bu yöntemlerden biri, arı zehri tedavisi,
dünyada şu anda uygulanan bir tekniktir. Arı zehri, peptitler, fosfolipitler,
biyoaktif aminler, amino asitler, şekerler, feromonlar, enzimler ve mineraller
gibi çok sayıda madde içermektedir. Arı zehrinin tümü ve içerdiği materyallere
ayrı ayrı yapılan çalışmalarda, bunların, antiinflamatuvar, antiartrit,
antinosiseptif, nöroprotektif, antitümöral, antimikrobiyal, antidiyabetik ve
antiromatizmal etki potantisiyeli açıkça gösterilmiştir. Artrit, Parkinson ve
Alzheimer hastalığı ile kansere yönelik in vivo çalışmalar ile antimikrobiyal
etkinlik gibi in vitro çalışmalarda son derece umut verici sonuçlar
gözlenmiştir. Her ne kadar etki mekanizması ve birçok biyoaktif içeriği henüz
aydınlatılmamış olsa da, belirli tıbbi durumlarda etkinliği açıkça görülmüştür.
Arı zehrinin biyoaktif komponentlerinin diğer başka hastalıklar için de yeni
kapılar açacağı düşünülmektedir.
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