Periungual pyogenic granuloma-like lesions are not uncommon side effects of isotretinoin therapy, but these cases are relatively infrequently reported. Excessive granulation tissue appeared in two ...patients receiving oral isotretinoin therapy for severe acne. Once isotretinoin was discontinued, the outgrowths resolved spontaneously in both patients. It is probably an idiosyncratic reaction to isotretinoin which renders the skin more susceptible to extracellular matrix and blood vessel formation. Moreover, similar lesions may be observed particularly with newer targeted therapies, such as inhibitors of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase kinases (MEKs). EGFR inhibitors associated painful periungual inflammation (paronychia), which often arises from the nail wall during newer targeted therapies, has been classified in the third major group of dermatologic toxicity. Cutaneous toxicity may be interpreted as a stress response that affects epidermal homeostasis. In the cell, stress signals are transmitted to effectors which then produce an inflammatory response.
In conclusion, paronychia and excessive granulation tissue in the nail folds are not uncommon side effects of oral retinoids. It is therefore particularly important for practicing dermatologists to be aware that the best management approach is drug discontinuation.
Suvremene obloge možemo podijeliti u skupine prema svojstvima (upijanja izlučevine), i s obzirom na to u kojim su fazama cijeljenja najučinkovitije. Jedna od podjela je podjela na osnovne obloge ili, ...bolje rečeno, materijale, koji se koriste za tretiranje svih vrsta rana (kao sekundarne obloge); obloge koje znatno apsorbiraju; alginatne obloge; obloge, koje djeluju antimikrobno (s dodatkom DACC, inadina, PHMB, srebra); fi lmovi; pjene; obloge s medom; hidrokoloidi; hidrogeli; obloge za suzbijanje neprijatnog vonja; obloge s modulatorima proteaza; obloge koje upotrebljavamo na brazgotinama; obloge za zaštitu kože; druge obloge koje su biocelulozne, obloge s kolagenom, obloge s poliuretanskim matriksom.
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