Perfume (Parfum) or fragrance is a natural or synthetic cosmetic ingredient added to emit a pleasant aroma or to improve the odor of a cosmetic formula. It is a mixture of substances, not revealed by ...the manufacturer, which may contain ingredients with allergenic potential, endocrine disruptors, and other possible harmful effects on human health. This study aims to analyze children's cosmetics labels to assess the presence of Perfume.
The researchers randomly visited points of sale in Curitiba, the capital of a southern Brazilian state; in order to catalog the largest possible number of children's cosmetics items.
398 children's cosmetics were analyzed and found Parfum on 295 (74.1 %) of the labels, including 90.4 and 79,1 % of the shampoos and wet wipes, respectively.
Exposure of children's skin to fragrances can lead to local side effects such as allergies, but also to systemic effects, and the lack of knowledge of the general population and health professionals about its possible deleterious effects emphasizes the importance of changes in the regulation of cosmetics aiming to reduce the use of this ingredient.
Background/Objectives
Nail clipping, the act of cutting the distal portion of a nail for microscopic analysis, can complement the diagnosis of skin diseases with nail involvement, such as psoriasis. ...This study aimed to describe histopathologic findings on 81 nails from 52 children and adolescents with skin psoriasis and to determine whether these changes correlated with the severity of skin and nail involvement.
Methods
Children with psoriasis were enrolled in this cross‐sectional study to obtain Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI) scores. The most altered nails were processed using periodic acid‐Schiff with diastase staining.
Results
Fifty‐two patients with a median age of 10.5 years were included. The median Nail Psoriasis Severity Index score of the 20 nails from these patients was 17 (range 3‐80). The most common findings were pitting (94.2%), leukonychia (73.0%), and longitudinal ridges (63.5%). Eighty‐one nail fragments were collected by clipping. Neutrophils were found in 6 samples (7.6%) and serous lakes in 15 (19%). Median nail plate thickness was 0.3 mm (range 0.1‐0.63 mm). Patients whose nails had neutrophils had a higher median PASI score (6.1 vs 2.0, P = .03). Patients whose nails had serous lakes had higher median PASI (5.3 vs 1.9, P = .008) and NAPSI (median 45.0 vs 18.0, P = .006) scores.
Conclusion
There seems to be a correlation between some microscopic nail features in children with psoriasis and their PASI and NAPSI scores, so nail clippings from children with suspected psoriasis may help with diagnosis, especially in the presence of neutrophils, and in excluding onychomycosis.
Hematohidrosis: insights in the pathophysiology Uber, Marjorie; Robl, Renata; Abagge, Kerstin T. ...
International journal of dermatology,
12/2015, Letnik:
54, Številka:
12
Journal Article
Fusarium oxysporum has been described as a pathogen causing onychomycosis, its incidence has been increasing in immunocompetent and disseminated infection can occur in immunosuppressed individuals. ...We describe the first case of congenital onychomycosis in a child caused by Fusarium oxysporum. The infection being acquired in utero was proven by molecular methods with the identification of the fungus both in the nail and placenta, most probably as an ascending contamination/infection in a HIV-positive, immunosuppressed mother.
: A 14‐year‐old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation. After 17 days she developed hemorrhagic cystitis due to polyoma BK virus (BKV), ...confirmed by PCR (polymerase chain reaction). Two weeks after the appearance of the urinary symptoms the patient presented numerous papules and vesicles on both hands and feet. PCR of the skin lesions and plasma was positive for BKV. The relationship of BKV with frequent infections in immunocompromised patients is well established. The positive PCR of vesicular fluid suggests that this was the causative agent of the skin lesion in this case. There are no reports of skin lesions with positive PCR for BKV.
OBJECTIVES: The present study aims to trace a pattern of patients referred to the specialized centers of pediatric dermatology, which were attended in a workforce on 2016. METHODS: It is a ...retrospective, cross-sectioned, observational and analytical study. Data were collected from the medical records. Children and adolescents from zero to sixteen years of age were included. Provided data were: age, sex, time of disease progression, previous treatments, comorbidities, diagnostic hypotheses, performed conducts, and outcomes. RESULTS: Of the 261 patients, 59% female, 13.8% infants, 31.4% preschoolers, 31.8% school, and 22.9% teenagers. The majority (62.5%) had no comorbidities, and among the 98 who presented some, a predominance of atopic diseases was observed: rhinitis in 22.6% and asthma in 15%. The majority, 63.2%, had already received some type of treatment. Eczematous disorders were the most prevalent (37.2%), followed by infectious ones (21%), benign hyperplasias and neoplasms (15.7%). Atopic dermatitis occurred in 19.9% of patients. Among the infections, viral infections occurred in a greater number (11.8%), mainly in the preschool and school groups. Among the glandular disorders, acne was the most frequent (11.5%), and its highest prevalence was in adolescents. More than a half, 52.5% of the patients were discharged, 32.6% were referred to pediatric dermatology and 9.6% were directed to maintain the follow-up in primary care. CONCLUSION: Eczematous disorders were the most frequent skin diseases, followed by infectious ones and by the group of benign hyperplasias and neoplasms. Among eczemas, atopic dermatitis was the most prevalent.
There is evidence that vitamin D (VD) supplementation may help in the management of atopic dermatitis (AD). The aim of this study was to assess the influence of VD supplementation on the severity of ...AD.
Pre-post interventional study with prospective data collection in patients younger than 14 years. The severity of AD was determined through SCORAD (SCORing Atopic Dermatitis) and classified as mild (SCORAD < 25), moderate (≥25 and <50), and severe (≥50). Skin prick test was performed in all patients. Serum VD levels were classified as sufficient (≥30 ng/mL), insufficient (29 to 21 ng/mL), and deficient (≤20 ng/mL); and those with inadequate levels received oral supplementation of VD for 3 months, and were reassessed after treatment.
A total of 152 patients were included. Patients with sufficient vitamin levels had lower SCORAD values (p = 0.04). Further, 116 patients (76.3%) received VD supplementation and after 3 months, VD levels were significantly higher (35.9 ng/mL) compared to baseline levels (23.7 ng/mL, p < 0.001). At the same time, a reduction in the SCORAD index was observed (19.4 before vs 12.3 after supplementation, p < 0.001). Considering other factors that could influence the decrease in AD severity after VD supplementation, female gender was associated with a worse treatment response (p = 0.02).
Vitamin D supplementation could be an adjuvant in reducing the severity of atopic dermatitis.
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