Abstract
Oscillatory properties of third-order half-linear neutral dynamic equations were investigated in this paper. Some conditions are obtained to ensure the oscillation of all solutions of a ...neutral dynamic equation with several coefficients and several variable delays,
t
∈ t
0
, ∞)
, where γ > 0 is a quotient of odd positive integers,
, and ,
and the results are supported by illustrative examples.
Exposure to aluminum chloride (AlCl3) induces progressive multiregional neurodegeneration in animal models by promoting oxidative stress and neuroinflammation. The current study was designed to ...assess the potential efficacy of the natural antioxidants celastrol and thymoquinone (TQ) for alleviating AlCl3-induced psychomotor abnormalities and oxidative-inflammatory burden in male albino rats. Four treatment groups were compared: (i) a vehicle control group, (ii) a AlCL3 group receiving daily intraperitoneal (i.p.) injection of AlCl3 (10 mg/kg) for 6 weeks, (iii) a AlCl3 plus TQ (10 mg/kg, i.p.) cotreatment group, and (iv) a AlCl3 plus celastrol (1 mg/kg, i.p.) cotreatment group. Open-field, rotarod, and forced swimming tests were conducted to assess locomotor activity, motor coordination, anxiety-like behavior, and depressive-like behavior. Acetylcholine (ACh), dopamine, and serotonin levels were measured in brain homogenates. Malondialdehyde (MDA), total antioxidant capacity (TAC), and catalase activity were measured as oxidative stress markers, while tumor necrosis factor-α (TNF-α) and interlukin-6 (IL-6) expression levels were measured as inflammatory markers. Brain derived neurotrophic factor (BDNF) mRNA was measured as an index for the endogenous neuroprotective response. Daily AlCl3 injection reduced free ambulation, impaired motor coordination, promoted anxiety- and depression-like behaviors, reduced whole-brain ACh, dopamine, and serotonin concentrations, increased MDA accumulation, reduced TAC, elevated TNF-α and IL-6, and suppressed BDNF mRNA expression. All of these effects were significantly reversed by TQ or celastrol cotreatment. Thus, TQ and celastrol may be promising treatments for AlCl3-induced neurotoxicity as well as neurodegenerative diseases involving oxidative stress and neuroinflammation.
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•AlCl3 produces psychomotor disturbances and muscle incoordination in male rats.•AlCl3 reduces brain neurotransmitters (Acetylcholine, dopamine and serotonin).•AlCl3 increases brain oxido-inflammatory burden and reduces expression of BDNF.•Thymoquinone ameliorated the behaviors, BDNF expression and biochemical deficits.•Celastrol improved the behaviors and downregulated the oxido-inflammatory burden.
Aims. Neuropathic pain following nerve injury does not respond well to most available pharmacological remedies. We aimed to compare the outcome of the addition of adipose-derived mesenchymal stem ...cells (ADMSCs) to pregabalin for neuropathic pain treatment. Methods. Adult female albino rats (n=100) were randomized to receive traumatic sciatic nerve injury or sham. Animals were then randomized to ADMSC treatment with or without pregabalin. We conducted a battery of neurobehavioral and electrophysiological to assess neuropathic pain. Following sacrifice, we evaluated the histological changes and gene expression of brain-derived neurotrophic factor (BDNF) in the sciatic nerve. Serum and sciatic nerve tissue pro- and inflammatory cytokine levels were also assessed. Results. (1) All treatments significantly improved thermal withdrawal latency, sciatic nerve conduction velocity, and proinflammatory cytokine levels in injured animals, with no significant effect of the combined treatments compared to pregabalin monotherapy (p<0.05 each). (2) Combined treatment significantly improved medial gastrocnemius electromyographic amplitude and sciatic function index compared to pregabalin monotherapy (p<0.05 each). (3) Combined treatment significantly increased the BDNF expression, decreased anti-inflammatory cytokine (p<0.05 each), and restored the structural nerve damage, compared to pregabalin monotherapy. Conclusions. Combined treatment is associated with greater improvement of the sciatic nerve structure and function. Further studies are warranted to study the mechanism of action of the combined treatment to improve neuropathic pain.
The topic of context is one of the important topics, which was mentioned as a concept in several fields and different fields, and there were many points of view that defined that concept.He specified ...the title of the research (design contexts in the design of the interior space), as the research sought to identify the concept of context in the interior design of the spaces of sewing workshops. The research was divided into four chapters:The first chapter, which consists of the methodological framework, the problem of research and the need for it, the importance of research, the goal and limits of research for sewing workshops for vocational schools from (2020-2021).The second chapter: consists of previous studies and the theoretical framework of two topics:The first topic: the concept of context in interior design.The second topic: spaces for sewing workshops.The third chapter: It consists of research procedures, and it is the research community. The descriptive approach was adopted in the sample analysis, which is considered one of the important research methods, in order to study phenomena, improve them, and solve problems. It diagnoses the phenomenon accurately to analyze the information and being the most appropriate with the direction of the research. At the end of the chapter, several results were produced according to the analysis form and the indicators of the theoretical framework.The fourth chapter: includes the results, conclusions, recommendations and proposals reached from this research, the most important of which are:1- A context is one of the main foundations for achieving meaning through simultaneous and sequential elements.2- Poor proportionality in the scale of the space led to poor perception and assimilation of the components of the internal space
The current research dealt with the study of space compatibility and its role in enhancing the functional aspect of the design of the interior spaces of isolation hospitals by finding a system or ...format that is compatible with the nature of the changes occurring in the structure and function of the space system, as well as contributing to enhancing compatibility between the functional aspect and the interior space. Therefore, the designer must The interior is the study of the functional and spatial aspects as they are the basic aspects for achieving suitability, and through the interaction between the person and the place, the utilitarian performance characteristics are generated that the interior designer is interested in and tries to develop and give them the appropriate design fit. The research consists of four chapters:* The first chapter: dealt with the research problem that was crystallized by the following question: “What is the role of spatial suitability in the process of change to embody the functional aspect of interior design?” The importance of the research is demonstrated by presenting a study necessitated by the necessity of raising the level of interior spaces, especially with regard to the issue of space suitability. The research also contributed to benefiting researchers and students regarding the results reached by the current research in the field of space suitability and confirming the functional aspect of interior design. The aim of the research is to clarify the role of adapting the interior space to the nature of the changes occurring in its systems and to confirm the functional aspect for which the space was designed. The first chapter also included the limits of the research (the objective limit, the spatial limit, the temporal limit) and the definition of terminology. The second chapter included the theoretical framework, which was divided into two sections, the first of which was: suitability, its concept, and its types. The second section was: the spatial organization of patient residence wards in hospitals
The formal integration of the interior spaces in general and the commercial spaces of the watch shops in the large commercial centers in particular is the goal that the designers aim to reach in ...order for the interior space to become successful in terms of the design idea and its characteristics. Implementation mechanism. One of the reasons for achieving formal integration in the interior spaces of watch shops is the requirements of the design that must be available in these spaces to reach a state of formal integration between the interior and the exterior so that the space becomes fully integrated in all respects. Because of the aforementioned reasons for dealing with the research, through four chapters: The first chapter included the research plan and its problem, which was summarized in the following question: (What are the design requirements that must be available in the interior design? Shop spaces that sell watches as commercial spaces require formal integration)? The importance of the research, its objective, the objective limits, the spatial and temporal limits of the research were also highlighted, and the most important terms mentioned in the research title were identified. As for the second chapter, it included previous studies and the theoretical framework, which included two parts. The first dealt with formal integration into the interior spaces. As for the second, it dealt with the internal commercial spaces in all its details, in addition to the results of the theoretical framework in terms of indicators. As for the third chapter, it was devoted to the research procedures, as the researcher relied on the descriptive approach in analyzing the selected samples and models. The fourth chapter also included the results of the analysis and the conclusions obtained in light of the research objective, recommendations and proposals. and a list of sources and appendices.
Peritoneal dialysis (PD) is an underutilized mode of dialysis therapy worldwide. Despite the reduction in peritonitis rate, peritonitis continues to be the main cause of technique failure. This study ...was undertaken to detection of the multiple bacterial strains in dialysis patients by melting curve analysis Real-time (RT-PCR). Ninety specimens of dialysate collected were blood culture and primers RT-PCR detection of the pathogens (bacterial). The results showed the most detected bacteria were Streptococcus pneumoniae (33%) followed by E. coli (31%), Staphylococcus aureus (13%), Klebsiella pneumoniae 11% then Pseudomonas aeruginosa (7%) respectively while the least frequency were recorded with Enterococcus faecalis with only (5%). From this study can concluded the identification of pathogens within two hours, Six bacterial pathogens have been detected and differentiated by using multiplex RT-PCR with peaks for melting curve study, high repeatability was exhibited for every amplification product.
Since ancient times, man has been keen to provide means of comfort and safety in his dwelling and the surrounding environment around that space by observing and harnessing them for his benefit within ...his dwelling or the space he uses. Surrounded by atmospheric, climatic, psychological and behavioral conditions and knowing the developments that occur in technology for the purpose of benefiting from them in adapting the environment that we use and we strive to make it ideal. Therefore, we must know the mechanisms and systems that bring us to this peak and try to achieve them or look at them for the purpose of using them in the correct scientific ways that provide us with psychological comfort Health, material and economic, through which we will address the mechanisms of environmental adaptation in the interior spaces of the gymnasiums. Their compatibility for gym users, the research also focused on presenting a study called for the need to improve the health and environmental level and knowledge of the mechanisms of environmental adaptation. It has the ability to detect environmental control systems and the extent to which internal space users adapt to them. As for the second chapter, it contained the details of the theoretical framework for the research and was divided into two chapters. The first chapter presented the environmental control systems in gymnasiums, and the second chapter presented theoretical interpretations of the concept of environment and adaptation. The methodology of the research adopted in the third chapter, which included the research procedures and methodology, so we relied on the descriptive approach of the total research community according to the reasons revealed in the analysis through the indicators of the theoretical framework, while the fourth chapter included a review of the results from which the theoretical material was summarized for the second chapter and from Most notably, the most important basics in achieving adaptation is that the space is independent and has a unit of idea and design of its own according to approved standards. For the purpose of achieving success, the designer must be aware of the nature of the region and its climate to control the adaptive, environmental and health systems, as well as knowing the amount of air, humidity and standard temperatures to achieve The best results
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