The amyloidosis is one of the histologic lesions the most frequently associated to the aging.
To identify the several etiologies of amyloidosis in elderly patients according to immunohistochemical ...type.
Retrospective study on 10 years, in Internal medicine and Nephrology department in Charles Nicolle Hospital. Tunis. Tunisia. Diagnosis of amyloidosis was retained after histological confirmation with specific colorations, in patients aged 65 years or more at the diagnose of amyloidosis.
The study enrolled 51 patients with amyloidosis. In 67% of cases it was AA amyloidosis. The etiology the most frequently observed with this type was the tuberculosis, followed by chronic pulmonary infections. We retained diagnose of non AA amyloidosis in 21% of patients. The multiple myeloma has been the most frequent etiology observed, but no cause was identified at about half of patients. Twelve per cent of amyloidosis were not typed.
From our study, we can remark the high predominance of AA amyloidosis, probably because of frequency of tuberculosis which is still high in our country, this is not in accordance with occidental data, were AL amyloidosis and senile amyloidosis predominate in elderly.
Renal involvement in Behcet's disease Ounissi, Mondher; Ben Abdelghani, Khaoula; Gargueh, Taher ...
Tunisie Medicale
88, Številka:
6
Journal Article
Recenzirano
Renal involvement in the Behcet's disease is rare. The clinical features vary from urinary sediment's abnormalities to ESRD.
We propose to study the clinical, biological and histological data, the ...therapeutic management and the prognosis of patients.
We report a retrospective study including 8 patients representing 1.23 % of cases.
The average age of the patient was of 37 +/- 12. 35 years with a clear male prevalence. Urinary signs were discovered fortuitously by the strips in the majority of the cases after an average of 18 months. It's about proteinuria and hematuria. Renal insufficiency and hypertension were rare. Pathological study highlighted 3 cases of amyloidosis, 2 cases of IgA nephropathy, 1 case of minimal change disease, 1 case of endo and extracapillary glomerulonephritis and 1 case of interstitial nephropathy. Patients having GN were treated by corticoids and immunosuppressive agents and those having an interstitial nephropathy were treated symptomatically with good evolution in the majority of the cases. Only one patient is dead, he had amyloidosis. Prognosis depended on the precocity of the diagnosis, the histological type and the treatment.
The renal involvement during Behçet's disease is rare. Amyloidosis and Ig A nephropathy are the most frequent. Treatment is still controversial.
Summary Background The applicability of the recent multi-ethnic reference equations derived by the ERS Global Lung Initiative (ERS/GLI) in interpreting spirometry data in North African adult subjects ...has not been studied. Objective To ascertain how well the recent ERS/GLI reference equations fit contemporary adult Tunisian spirometric data. Population and methods Spirometric data were recorded from 1192 consecutive spirometry procedures in adults aged 18–60 years. Reference values and lower limits of normality (LLN) were calculated using the local and the ERS/GLI reference equations. Applied definitions : large airway obstructive ventilatory defect ( LAOVD ): FEV1 /FVC < LLN. Tendency to a restrictive ventilatory defect ( TRVD ): FEV1 and FVC < LLN and FEV1 /FVC ≥ LLN. The spirometric profile, according to the two reference equations, was determined. Z-scores for spirometry from North African healthy subjects ( n = 489) were calculated. If the average Z-score deviated by <±0.5 from the overall mean, the ERS/GLI reference equations would be considered as reflective of contemporary Tunisian spirometry. Results Using Tunisian reference equations, 71.31%, 6.71% and 19.04% of spirometry records were interpreted as normal, and as having, LAOVD and TRVD, respectively. Using the ERS/GLI reference equations, these figures were respectively, 85.82%, 4.19% and 8.39%. The mean ± SD Z-scores for the contemporary healthy North African subject's data were −0.55 ± 0.87 for FEV1 , −0.62 ± 0.86 for FVC and 0.10 ± 0.73 for FEV1 /FVC. Conclusion The present study don't recommend the use of the recent ERS/GLI reference equations to interpret spirometry in North African adult population.
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