This study explores adolescent well-being during the first wave of the COVID-19 pandemic in two high-income countries from Europe and one middle-income country from South America. The aim is to ...investigate the correlates of different dimensions of subjective well-being in 10- to 16-year-olds from different cultural contexts.
An online, self-report questionnaire was completed by 1,613 adolescents in Luxembourg, Germany, and Brazil between May and July 2020. The outcome variables were measures of life satisfaction and emotional well-being during the COVID-19 pandemic. The study included a range of sociodemographic, interpersonal, and intrapersonal covariates. Data were analyzed using descriptive statistics and latent variable structural equational modeling.
A two-factor model of subjective well-being, consisting of life satisfaction and emotional well-being latent constructs, fitted well with this sample data for Luxembourg, Germany, and Brazil. Results showed that gender, socioeconomic status, intrapersonal factors, quantity and type of schoolwork, and relationships with adults were important common predictors of individual differences in subjective well-being during COVID-19. Fear of illness emerged as the strongest correlate of emotional well-being across the three countries.
This study indicates that girls and adolescents from low-income homes may be especially vulnerable to negative secondary impacts of COVID-19 that can affect mental health. It identified several common correlates of subjective well-being in adolescents from different cultural settings, including factors that may be changeable, such as the following: the way adults listen to adolescents, schoolwork during distant learning, and fear of illness. Findings can inform the development of quality interventions for promoting the well-being of adolescents during a global pandemic.
Lean-Green is a concept that associates value aggregation and efficiency in operational and environmental terms. This concept arises as a corollary effect of companies’ challenges for rethinking ...their goals and strategies in order to add more value while contributing to social equity and prevent environmental burdens. The eco-efficiency concept translates the idea of “creating more with less”, in order to reduce ecological impacts and resource intensity. Lean is a strategy that encompasses a wide variety of management practices, in an integrated system, to streamline business processes, minimize waste and improve financial performance. When Lean and Green are associated in the so called Lean-Green link, many of those savings also result in environmental benefits. This paper reports the ongoing effort to provide models for the Lean-Green integration. A comparative analysis of the few models identified is provided, and the most frequently used KPI acknowledged. Findings show the existence of a limited number of Lean-Green models, published from 2012, denoting a narrow breadth of dissemination. The fundamental goal of Lean-Green models was mostly found to be related to improve the systems productivity while reducing the environmental impacts. Integrate Lean-Green initiatives constitute a valuable approach to sustain and endure a greener industrial activity.
•There is a synergetic relationship between Lean and Green Manufacturing.•A limited number of Lean-Green models are found on the existing literature.•Lean-Green may sustain a cleaner industrial activity and lessen its energy intensity.•Lean-Green models tackle all major waste types arisen on the factory shop floors.•A number of key performance indicators are common to the existing Lean-Green models.
This study explores whether the cognitive advantage associated with bilingualism in executive functioning extends to young immigrant children challenged by poverty and, if it does, which specific ...processes are most affected. In the study reported here, 40 Portuguese-Luxembourgish bilingual children from low-income immigrant families in Luxembourg and 40 matched monolingual children from Portugal completed visuospatial tests of working memory, abstract reasoning, selective attention, and interference suppression. Two broad cognitive factors of executive functioning—representation (abstract reasoning and working memory) and control (selective attention and interference suppression)—emerged from principal component analysis. Whereas there were no group differences in representation, the bilinguals performed significantly better than did the monolinguals in control. These results demonstrate, first, that the bilingual advantage is neither confounded with nor limited by socioeconomic and cultural factors and, second, that separable aspects of executive functioning are differentially affected by bilingualism. The bilingual advantage lies in control but not in visuospatial representational processes.
Accelerated cosmos in a nonextensive setup Moradpour, H.; Bonilla, Alexander; Abreu, Everton M. C. ...
Physical review. D,
12/2017, Letnik:
96, Številka:
12
Journal Article
Recenzirano
Odprti dostop
Here we consider a flat FRW universe whose horizon entropy meets the Rényi entropy of nonextensive systems. In our model, the ordinary energy-momentum conservation law is not always valid. By ...applying the Clausius relation as well as the Cai-Kim temperature to the apparent horizon of a flat FRW universe, we obtain modified Friedmann equations. Fitting the model to the observational data on the current accelerated universe, some values for the model parameters are also addressed. Our study shows that the current accelerating phase of universe expansion may be described by a geometrical fluid, originated from the nonextensive aspects of geometry, which models a varying dark energy source interacting with the matter field in the Rastall way. Moreover, our results indicate that the probable nonextensive features of spacetime may also be used to model a varying dark energy source which does not interact with the matter field and is compatible with the current accelerated phase of the Universe.
Through the last years, it was demonstrated that quantum corrections of entropy, represented by logarithmic and power law corrections terms, constituted an association between semi-classical entropic ...areas and the curvature correction in Einstein–Hilbert’s Lagrangian and vice-versa. Loop quantum gravity approach provided the logarithmic corrections, which arises from quantum and thermal equilibrium fluctuations. On the other hand, Barrow’s entropy was introduced from the fact that the black hole surface can be modified due to quantum gravitational effects. The new exponent
Δ
that appears in Barrow’s entropy is a measure of this perturbation. In this letter we have analyzed the thermodynamical effects of the quantum fluctuations upon the geometry of a Barrow’s black hole. We demonstrated that new formulations of the equipartition law, which corresponds to the horizon energy, can be constructed from both entropic formalisms. Besides, we have calculated the heat capacity for both formulations and we discussed their thermal viability. We have also establish a condition on one of the constant pre-factors of the logarithmic correction.
Aim and Methods
Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the ...antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure–activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro‐organisms.
Results
2,4‐Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram‐negative and Gram‐positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin‐susceptible Staphylococcus aureus. MRSA was inhibited by 2,4‐dihydroxybenzoic, vanillic, syringic (MICs = 0·5 mg ml−1) and p‐coumaric (MIC = 1 mg ml−1) acids, while these compounds at the same concentrations had no inhibitory effects against methicillin‐susceptible Staph. aureus.
Conclusions
The presence of carboxylic acid (COOH), two hydroxyl (OH) groups in para and ortho positions of the benzene ring and also a methoxyl (OCH3) group in the meta position seems to be important for anti‐MRSA activity.
Significance and Impact of the Study
Phenolic compounds could be used as antimicrobial agents, namely against some micro‐organisms resistant to commercial antibiotics.
The efficacy of ustekinumab, an antagonist of the p40 subunit of interleukin-12 and interleukin-23, as induction and maintenance therapy in patients with ulcerative colitis is unknown.
We evaluated ...ustekinumab as 8-week induction therapy and 44-week maintenance therapy in patients with moderate-to-severe ulcerative colitis. A total of 961 patients were randomly assigned to receive an intravenous induction dose of ustekinumab (either 130 mg 320 patients or a weight-range-based dose that approximated 6 mg per kilogram of body weight 322) or placebo (319). Patients who had a response to induction therapy 8 weeks after administration of intravenous ustekinumab were randomly assigned again to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 12 weeks 172 patients or every 8 weeks 176) or placebo (175). The primary end point in the induction trial (week 8) and the maintenance trial (week 44) was clinical remission (defined as a total score of ≤2 on the Mayo scale range, 0 to 12, with higher scores indicating more severe disease and no subscore >1 range, 0 to 3 on any of the four Mayo scale components).
The percentage of patients who had clinical remission at week 8 among patients who received intravenous ustekinumab at a dose of 130 mg (15.6%) or 6 mg per kilogram (15.5%) was significantly higher than that among patients who received placebo (5.3%) (P<0.001 for both comparisons). Among patients who had a response to induction therapy with ustekinumab and underwent a second randomization, the percentage of patients who had clinical remission at week 44 was significantly higher among patients assigned to 90 mg of subcutaneous ustekinumab every 12 weeks (38.4%) or every 8 weeks (43.8%) than among those assigned to placebo (24.0%) (P = 0.002 and P<0.001, respectively). The incidence of serious adverse events with ustekinumab was similar to that with placebo. Through 52 weeks of exposure, there were two deaths (one each from acute respiratory distress syndrome and hemorrhage from esophageal varices) and seven cases of cancer (one each of prostate, colon, renal papillary, and rectal cancer and three nonmelanoma skin cancers) among 825 patients who received ustekinumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received placebo.
Ustekinumab was more effective than placebo for inducing and maintaining remission in patients with moderate-to-severe ulcerative colitis. (Funded by Janssen Research and Development; UNIFI ClinicalTrials.gov number, NCT02407236.).
We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs.
...). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = 137) and hearing assessments (n = 114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32 months of age. Among children assessed by Bayley-III, 12% scored below -2 s.d. (score <70; a score of 100 ± 2 s.d. is the range) in at least one domain; and 28% scored between -1 and -2 s.d. in any domain (scores <85-70). Language function was most affected, with 35% of 146 children below average. Improved neurodevelopmental outcomes were noted in female children, term babies, children with normal eye exams and maternal infection later in pregnancy (P = 0.01). We noted resolution of microcephaly with normal neurodevelopment in two of eight children, development of secondary microcephaly in two other children and autism spectrum disorder in three previously healthy children in the second year of life.
Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown ...leprosy cases in midwestern Brazil and to compare the performance of different serological tests.
A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test. New cases of leprosy and the impact of performing this broad random surveillance strategy were evaluated. Accuracy values and concordance between the test results were evaluated among all groups.
Four hundred thirty-four individuals were evaluated, and 44 (10.1%) were diagnosed with leprosy. Borderline forms were the most frequent presentation. Both tests presented higher positivity in those individuals with multibacillary disease. Serological tests demonstrated specificities arround 70% for anti-PGL-1 and anti-LID ELISA; and arround 40% for NDO-LID. Sensitivities ranged from 48 to 62%. A substantial agreement between NDO-LID and ELISA with concomitant positive results was found within leprosy patients (Kappa index = 0.79 CI95% 0.36-1.22).
The unexpectedly high leprosy prevalence in this population indicates ongoing community-based exposure to Mycobacterium leprae antigens and high rates of subclinical infection. All tests showed low specificity and sensitivity values and therefore cannot be considered for use as stand-alone diagnostics. Rather, considering their positivity among MB patients and non-patients, these tests can be considered effective tools for screening and identifying individuals at high risk who might benefit from regular monitoring.
The Alcubierre metric is a spacetime geometry where a massive particle inside a spacetime distortion, called warp bubble, is able to travel at velocities arbitrarily higher than the velocity of ...light, a feature known as the warp drive. This is a consequence of general relativity, which allows for global superluminal velocities but restricts local speeds to subluminal ones as required by special relativity. In this work we solved the Einstein equations for the Alcubierre warp drive spacetime geometry considering the dust matter distribution as source, since the Alcubierre metric was not originally advanced as a solution of the Einstein equations, but as a spacetime geometry proposed without a source gravity field. We found that all Einstein equations solutions of this geometry containing pressureless dust lead to vacuum solutions. We also concluded that these solutions connect the Alcubierre metric to the Burgers equation, which describes shock waves moving through an inviscid fluid. Our results also indicated that these shock waves behave as plane waves.
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