This article addresses the principal theoretical-methodological matrixes of the debate about territory, considering studies from the fields of geography and the social sciences that are commonly used ...as references for understanding the issue in its broad epistemological spectrum. It is a detailed bibliographic study that indicates some frontiers, traps and walls that are subjacent to the theme. Territory rises as a key element in public polices and thus in social service, as a socio-historic construction of globalized capital in crisis in a situation of destruction of social guarantees, as a panacea to capitalist development in economically dependent countries. The articles raises the trends of this debate and shows how it can be constituted as a fundamental mediation in the analysis of the processes and flows found in social transformations and their space-time dialectic. Beyond abstract-formal and post-modern definitions, it is important to locate the theme of territory at the foundation of the class struggle that expresses social life in movement.
This study aimed to investigate the effects of cyclosporine on the morphology, cell wall structure, and secretion characteristics of
. The minimum inhibitory concentration (MIC) of cyclosporine was ...found to be 2 µM (2.4 µg/mL) for the H99 strain. Yeast cells treated with cyclosporine at half the MIC showed altered morphology, including irregular shapes and elongated projections, without an effect on cell metabolism. Cyclosporine treatment resulted in an 18-fold increase in chitin and an 8-fold increase in lipid bodies, demonstrating changes in the fungal cell wall structure. Cyclosporine also reduced cell body and polysaccharide capsule diameters, with a significant reduction in urease secretion in
cultures. Additionally, the study showed that cyclosporine increased the viscosity of secreted polysaccharides and reduced the electronegativity and conductance of cells. The findings suggest that cyclosporine has significant effects on
morphology, cell wall structure, and secretion, which could have implications for the development of new antifungal agents.
•Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease.•Açai (Euterpe oleracea) fruit contains high levels of polyphenols, e.g. anthocyanins.•Mice with high-fat diet-induced ...NAFLD received oral aqueous açai extract (AAE).•AAE increased adiponectin levels, insulin sensitivity and PPAR-α-mediated fatty acid oxidation, decreasing liver lipids.
Polyphenols, especially anthocyanins, have been considered promising for the prevention of nonalcoholic fatty liver disease (NAFLD). This study investigated whether açai (Euterpe oleracea Mart.), a source of anthocyanins and recognized as one of the new “superfruits”, could alleviate high-fat diet (HFD)-induced NAFLD in mice. In HFD mice, aqueous açai extract (AAE) administration (3 g/kg) for six weeks improved insulin resistance index and increased adiponectin mRNA expression in adipose tissue and serum levels. Furthermore, AAE decreased the total liver triacylglycerol content and attenuated HFD-induced hepatic steatosis. This reduced hepatic lipid content was associated with AAE-mediated up-regulation of genes involved in adiponectin signaling, including adiponectin receptor 2, PPAR-α, and its target gene, carnitine palmitoyltransferase. Thus, dietary açai can protect liver from steatosis through its enhancement of adiponectin levels, improvement of insulin sensitivity, and increase in PPAR-α-mediated fatty acid oxidation.
to identify the lifetime use of alcohol and other drugs among users of the Family Health Strategy and apply Brief Intervention to problems related to the use of these substances.
a descriptive ...cross-sectional study where 1,031 users of the Family Health Strategy of the city of Rio de Janeiro answered a form with socio-demographic information and the Alcohol, Smoking and Substance Involvement Screening Test. Statistical analysis with simple frequency distribution was performed.
the most commonly used drugs in lifetime were alcohol and tobacco; among the illegal drugs, marijuana, hypnotics and cocaine/crack stood out. Those who received most Brief Intervention were users of tobacco, hypnotics, marijuana, cocaine/crack and alcohol.
it is important to detect early problems associated with the use of alcohol and other drugs in Primary Care, since it has the promotion/protection of health and the prevention of diseases as priority health practices.
Abstract Etlingera is a genus of the family Zingiberaceae that is native to tropical Asia. Many species are economically important as a source of food, spices, medicines, and ornamental plants. This ...study aims to elucidate the floral morphology of E. elatior and understand the behavior of the set of stamen and style during floral anthesis, seeking to identify the mechanisms that promote xenogamy in the species. Flower morphology, time of anthesis and movement of the stamen and style during this period, pollen viability, nectar volume, floral visitors, and the reproductive system were evaluated. The flowers of E. elatior exhibited synchronous movement of the style and stamen, however, this movement was not considered as flexistyly, since the species does not present dichogamy. The synchronous movement of the stamen and pistil, by itself, was not enough to promote self-pollination. Fruiting depends on pollinators. The stigma fluid is an important means whereby pollen adheres to the mouthpart of the pollinator. Hummingbirds and bees were considered the most effective pollinators of E. elatior in the area studied.
Resumo Etlingera é um gênero da família Zingiberaceae nativo da Ásia tropical. Muitas espécies são economicamente importantes como fonte de alimentos, especiarias, medicamentos e plantas ornamentais. Este estudo tem como objetivo elucidar a morfologia floral de E. elatior e compreender o comportamento do estame e do estilete durante a antese floral, buscando identificar os mecanismos que promovem a xenogamia na espécie. Foram avaliados morfologia floral, tempo de antese e movimentação do estame e estilete neste período, viabilidade polínica, volume de néctar, visitantes florais e sistema reprodutivo. As flores de E. elatior exibiram movimento sincrônico do estilete e do estame, porém, esse movimento não foi considerado como flexistilia, uma vez que a espécie não apresenta dicogamia. O movimento sincrônico do estame e estilete, por si só, não foi suficiente para promover a autopolinização na espécie. A frutificação depende da ação de polinizadores. O fluido do estigma é um meio importante pelo qual o pólen adere ao aparelho bucal do polinizador. Beija-flores e abelhas foram considerados os polinizadores mais eficazes de E. elatior na área estudada.
ObjectiveDue to its multisystemic involvement, Systemic Lupus Erythematosus (SLE) can have a significant impact on quality of life (QoL). Sexual (dys)function is a key component of QoL but is often ...underappreciated. Little is known about sexual dysfunction in SLE patients, a condition that primarily affects women during fertile age. We aimed at determining the prevalence of sexual dysfunction among SLE women and predictors thereof.MethodsWe performed a cross-sectional multicentre study in which women (18–70 years-old) with a clinical diagnosis of SLE were included. An anonymous online questionnaire was performed where data on demographics, symptoms of depression and anxiety (HADS), health-related QoL (SF36) and sexual function (Female Sexual Function Index FSFI - a 19-item patient-report outcome that assesses female sexual function) were collected. Data on clinical features (disease activity according to the SELENA-SLEDAI, organ involvement and evaluation of comorbidity Charlson Comorbidity Index) and on treatment status were collected from medical records. The main outcome was sexual dysfunction, defined as FSFI<26.5 (validated cut-off). A multivariable logistic regression was performed to test the association of clinical and demographic characteristics with sexual dysfunction (present vs absent).ResultsIn total, 194 female patients with SLE were included (mean age 44 years-old SD 11). The mean SELENA-SLEDAI score was 1.7 (SD 2.2), corresponding to low disease activity, and 94% of patients were on cDMARD’s. The mean value of HADS was 9 (0–21), for both depression and anxiety scores. Regarding SF36, the mental component had a mean value of 61 (0–100) and the physical one of 70 (0–100). Sexual dysfunction was present in 128 (66%) patients.In the multivariable analysis (table 1), older age (OR: 1.04; 95%CI: 1.01; 1.07), higher SELENA-SLEDAI (OR: 1.18; 95%CI: 1.01; 1.40), higher HADS depression score (OR: 1.20; 95%CI: 1.01; 1.43), as well as a lower (that is, worse) SF36 mental component score (OR: 0.97; 95%CI: 0.95; 0.98) were independently associated with sexual dysfunction.ConclusionSexual dysfunction is common in women with SLE and is influenced by both physical and mental health components. Clinicians should consider both for the optimal management of their patients in order to improve their sexual QoL.
Poultry are considered to be the main reservoir of Campylobacter spp. bacteria, an important pathogen for humans. Many studies have reported a rapid selection of fluoroquinolone-resistant strains ...following the widespread use of these antimicrobials in poultry production and human medicine. The main mechanism of fluoroquinolone resistance in Campylobacter is a mutation in the Quinolone Resistance Determinant Region (QRDR) in the gyrA gene, which codes for the subunit of the enzyme DNA gyrase, the target for fluoroquinolone. The aim of this study was to investigate the mutation in QRDR in the gyrA gene of Campylobacter strains previously isolated from broiler carcasses and feces of laying hens. Thirty-eight strains of C. jejuni and 19 C. coli strains (n=57), previously characterized as resistant to ciprofloxacin and enrofloxacin by the disk diffusion method and minimum inhibitory concentration (MIC), were selected. For detection of the mutation, a fragment of 454pb QRDR in the gyrA gene was used for direct sequencing. All strains presented the QRDR mutation in the gyrA gene at codon 86 (Thr-86-Ile), which confers resistance to fluoroquinolones. Other known silent mutations were observed. This genotypic characterization of fluoroquinolone resistance in Campylobacter strains has confirmed the prior phenotypic detection of the resistance. The Thr-86-Ile mutation was observed in all samples confirming that this is the predominant mutation in enrofloxacin and ciprofloxacin resistant strains of C. jejuni and C. coli.
As aves são consideradas o principal reservatório de Campylobacter spp., um importante patógeno para humanos e muitos estudos têm relatado uma rápida seleção de cepas resistentes às fluoroquinolonas após o uso destes antimicrobianos na produção avícola e na medicina humana. O principal mecanismo de resistência às fluoroquinolonas em Campylobacter consiste na mutação na Região Determinantes de Resistência às Quinolonas (RDRQ) do gene gyrA, que codifica para a subunidade A da enzima DNA girase, alvo das fluoroquinolonas. O objetivo deste estudo foi investigar a mutação na RDRQ do gene gyrA em cepas de Campylobacter previamente isolados de carcaças de frangos de corte e fezes de galinhas poedeiras. Foram selecionadas 38 cepas de C. jejuni e 19 cepas de C. coli (n=57), previamente caracterizadas como resistentes à ciprofloxacina e enrofloxacina, pelo método da difusão em disco e pela determinação da concentração inibitória mínima. Para detecção da mutação, foi utilizado sequenciamento direto de um fragmento de 454pb da RDRQ do gene gyrA gerado por PCR. Todas as cepas apresentaram a mutação na RDRQ do gene gyrA no códon 86 (Tre-86-Ile), que confere resistência às fluoroquinolonas e outras mutações silenciosas foram observadas. A caracterização genotípica da resistência às fluoroquinolonas em Campylobacter confirmou a prévia detecção fenotípica dessa resistência e a mutação Tre-86-Ile foi observada na totalidade das amostras, comprovando ser esta a mutação predominante em cepas de C. jejuni e C. coli resistentes à enrofloxacina e ciprofloxacina.
O objetivo deste artigo é debater sobre a formação do professor de Português (FPP) do Curso de Letras da Universidade Federal do Pará (UFPA), no campus de Castanhal, localizado numa região onde duas ...comunidades linguístico-culturais têm destaque: a indígena e a quilombola. Para isso, assumimos como opção metodológica uma análise documental do Projeto Pedagógico do Curso (PPC), do ementário e de dois planos de curso, procurando evidenciar preocupações voltadas para a Diversidade Linguística e Cultural (DLC) e contribuir para as discussões sobre o respeito a essa diversidade. Como resultado destacamos que, embora existam alguns direcionamentos no PPC e no ementário, não encontramos, de forma sistematizada nos planos de curso, ações que promovam o conhecimento sobre a DLC da região e sobre o respeito às línguas e culturas que fazem parte da Língua Portuguesa (LP). Essa lacuna nos leva a concluir que há dificuldade em colocar em prática o que propõem as leis sobre a obrigatoriedade do ensino da história e cultura afro e indígena. Além disso, não encontramos indicações nos documentos analisados sobre a LP no mundo e suas variantes.
A total of 74 methicillin-resistant Staphylococcus aureus (MRSA)
strains isolated from three government hospitals in 2002 and 2003 were
examined concerning the distribution of qacA/B gene, which is ...the
determinant of resistance to quaternary ammonium compounds largely
employed in hospital disinfection. By polymerase chain reaction the
qacA/B gene was found in 80% of the isolates, which is a significant
result considering it is the first time that qacA/B gene is being
reported for Brazilian MRSA strains and it is presented at a high rate.
Purpose: to analyze the students' understanding of public health training in the speechlanguage-hearing programs at public universities in Northeastern Brazil. Methods: a qualitative, multiple-case ...study that interviewed key informing students of seven universities in the Northeast to collect data. The analysis was based on the theme content analysis technique, having as theoretical reference the conception of curricula. Results: three categories emerged from the analysis: public health training experiences, influence of the experiences at the Unified Health System (Sistema Unico de Saude--SUS) on the speech-language-hearing therapist's training, and potentials and limitations in public health training. Conclusion: the public university students of Northeastern Brazil perceive public health training as a means to prepare them for their future inclusion and professional practice at SUS. Keywords: Education, higher; Speech, Language and Hearing Science; Public Health
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