The authors present the case of a 60-year-old patient admitted for diabetes mellitus. Primary (hereditary) hemochromatosis was diagnosed as the pathological background of diabetes as well as the ...associated symptoms (weight loss, arthrosis, erectile dysfunction, supraventricular arrhythmia, hepatic cirrhosis). To eliminate the accumulated excess iron, phlebotomy cycles were started. Family screening revealed two other affected patients who contrary to the index-patient were free of complaints. Phlebotomy was, however, started in one of these patients because of abnormal laboratory values consistent with iron-overload. For the prevention of the symptoms early diagnosis is important. Although some of the symptoms can disappear, the most severe changes (cirrhosis, diabetes) are irreversible. Latest knowledge about the pathophysiology including the genetic background and the practice of diagnosis and treatment of the disease are discussed as well.
The physical processes occurring within the inner few astronomical units of proto-planetary disks surrounding Herbig Ae stars are crucial to setting the environment in which the outer planet-forming ...disk evolves and put critical constraints on the processes of accretion and planet migration. We present the most complete published sample of high angular resolution H- and K-band observations of the stars HD 163296 and HD 190073, including 30 previously unpublished nights of observations of the former and 45 nights of the latter with the CHARA long-baseline interferometer, in addition to archival VLTI data. We confirm previous observations suggesting significant near-infrared emission originates within the putative dust evaporation front of HD 163296 and show this is the case for HD 190073 as well. The H- and K-band sizes are the same within \((3 \pm 3)\%\) for HD 163296 and within \((6 \pm 10)\%\) for HD 190073. The radial surface brightness profiles for both disks are remarkably Gaussian-like with little or no sign of the sharp edge expected for a dust evaporation front. Coupled with spectral energy distribution analysis, our direct measurements of the stellar flux component at H and K bands suggest that HD 190073 is much younger (<400 kyr) and more massive (~5.6 M\(_\odot\)) than previously thought, mainly as a consequence of the new Gaia distance (891 pc).
MsEnod12A and MsEnod12B are two early nodulin genes from alfalfa (Medicago sativa). Differential expression of these genes was demonstrated using a reverse transcription-polymerase chain reaction ...approach. MsEnod12A RNA was detected only in nodules and not in other plant tissues. In contrast, MsEnod12B transcripts were found in nodules and also at low levels in roots, flowers, stems, and leaves. MsEnod12B expression was enhanced in the root early after inoculation with the microsymbiont Rhizobium meliloti and after treatment with purified Nod factors, whereas MsEnod12A induction was detected only when developing nodules were visible. In situ hybridization showed that in nodules, MsEnod12 expression occurred in the infection zone. In empty Fix- nodules the MsEnod12A transcript level was much reduced, and in spontaneous nodules it was not detectable. These data indicate that MsEnod12B expression in roots is related to the action of Nod factors, whereas MsEnod12A expression is associated with the invasion process in nodules. Therefore, alfalfa possesses different mechanisms regulating MsEnod12A and MsEnod12B expression.
Alpha Ophiuchi (Rasalhague) is a nearby rapidly rotating A5IV star which has been imaged by infrared interferometry. \(\alpha\) Oph is also part of a known binary system, with a companion semi-major ...axis of \(\sim\)430 milli-arcseconds and high eccentricity of 0.92. The binary companion provides the unique opportunity to measure the dynamical mass to compare with the results of rapid rotator evolution models. The lack of data near periastron passage limited the precision of mass measurements in previous work. We add new interferometric data from the MIRC combiner at the CHARA Array as well as new Keck adaptive optics imaging data with NIRC2, including epochs taken near periastron passage. We also obtained new radial velocities of both components at Fairborn Observatory. Our updated combined orbit for the system drastically reduces the errors of the orbital elements, and allows for precise measurement of the primary star mass at the few percent level. Our resulting primary star mass of \(2.20\pm0.06\) M\(_{\odot}\) agrees well with predictions from imaging results, and matches evolution models with rotation when plotting on an HR diagram. However, to truly distinguish between non-rotating and rotating evolution models for this system we need \(\sim\)1\% errors on mass, which might be achieved once the distance is known to higher precision in future Gaia releases. We find that the secondary mass of \(0.824\pm0.023\) M\(_{\odot}\) is slightly under-luminous when compared to stellar evolution models. We show that \(\alpha\) Oph is a useful reference source for programs that need \(\pm\)1 milli-arcsecond astrometry.
We show that in both time-dependent and state-dependent sticky price models, prices of sticky price products (i.e. whose price changes rarely) contain more information about medium term inflation ...developments than those of flexible price products (i.e. whose price changes frequently). We do this by establishing a novel measure for the extent of forwardlookingness of newly set prices, and showing that it is at least 60% when the monthly price change frequency is less than 15%. This result is robust across various sticky price models. On the empirical front, we show that the Hungarian sticky price inflation index indeed has a forward-looking component, as it has favorable inflation forecasting properties on the policy horizon of 1-2 years to alternative inflation indicators (including core inflation). Both theoretical and empirical results suggest that the sticky price inflation index is a useful indicator for inflation targeting central banks.
Cyclins in association with the protein kinase p34cdc2 and related cyclin-dependent protein kinases (cdks) are key regulatory elements in controlling the cell division cycle. Here, we describe the ...identification and characterization of a full-length cDNA clone of alfalfa mitotic cyclin, termed CycIIIMs. Computer analysis of known plant cyclin gene sequences revealed that this cyclin belongs to the same structural group as the other known partial alfalfa cyclin sequences. Genetic segregation analysis based on DNA-DNA hybridization data showed that the CycIIIMs gene(s) locates in a single chromosomal region on linkage group 5 of the alfalfa genetic map between RFLP markers UO89A and CG13. The assignment of this cyclin to the mitotic cyclin class was based on its cDNA-derived sequence and its differential expression during G2/M cell cycle phase transition of a partially synchronized alfalfa cell culture. Sequence analysis indicated common motifs with both the A- and B-types of mitotic cyclins similarly to the newly described B3-type of animal cyclins.
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