Diversity and Inclusion Luncheon: Report and Recommendations Sonnenwald, Diane H; Harrison, Lauren; Bar-Ilan, Judit ...
Bulletin of the American Society for Information Science and Technology (Online),
06/2017, Letnik:
43, Številka:
5
Trade Publication Article
ASIS&T has continuously worked to enhance diversity and inclusion over its long history, including the formation of the Special Interest Group/International Information Issues and the name change ...from the American Society for Information Science and Technology to the Association for Information Science and Technology. During the 2016 ASIS&T Annual Meeting (AM), a Diversity and Inclusion Luncheon was held to promote discussion and ideas of new ways for ASIS&T to promote diversity. Attendees of the luncheon were asked to share positive personal experiences with diversity, as well as share ideas for how to bolster diversity and inclusion in future AMs and for ASIS&T as an organization. Suggestions include the meeting being held outside of North America more frequently, inclusion of mentor programs for papers and new attendees of AMs, removing North American-centric language from communications and more ASIS&T board members from other continents. The suggestions were recommended to the ASIS&T Board for further discussion.
In an open, observational study, 40 consecutive ischemic stroke patients eligible for thrombolytic therapy using the combined ECASS/NINDS inclusion criteria have been treated intravenously with 1.5 M ...units of streptokinase. The therapeutic window was 3 hours or shorter.
The safety analysis documented a low rate (5%) of intracerebral hemorrhages, and an additional 13% rate of hemorrhagic transformation of the initial infarction. Two patients died due to intracerebral bleeding. The efficacy of the SK thrombolysis was significant in 53% of the patients (the mean of the improvement on the NIH stroke scale was 15 points), while an other 42% of the patients achieved only the mean of 4 points improvement on their NIHSS score.
These results are of the same magnitude, as those documented in the NINDS trial with rt-PA. Time window rather than the thrombolytic agent itself seems to be the decisive factor for successful thrombolysis.
The good safety profile of SK in acute stroke using the ECASS/NINDS criteria, and the cost-effectiveness of the drug underline the necessity of a new SK trial with the recently accepted inclusion and exclusion criteria.
Positron emission tomography (PET) is a useful tool for the investigation of certain physiological changes and for the evaluation of the distribution, and receptor binding of drugs labelled with ...positron emitting isotopes. Vinpocetine (ethyl-apovincaminate) is a neuroprotective drug widely used in the prevention and treatment of cerebrovascular diseases. In the clinical practice vinpocetine is usually administered to the patients in intravenous infusion followed by long-term oral treatment. Until presently human data describing vinpocetine's kinetics and brain distribution came from ex vivo (blood, plasma, liquor) and post mortem (brain autoradiography) measurements.
The authors wished to investigate the kinetics and distribution of vinpocetine in the brain and body after oral administration with PET in order to prove, that PET is useful in the non-invasive in vivo determination of these parameters.
Vinpocetine was labelled with carbon-11 and the radioactivity was measured by PET in the stomach, liver, brain, colon and kidneys in healthy male volunteers. The radioactivity in the blood and urine was also determined.
After oral administration, 11Cvinpocetine appeared immediately in the stomach and within minutes in the liver and the blood. In the blood the level of radioactivity continuously increased until the end of the measurement period, whereas the fraction of the unchanged mother compound decreased. Radioactivity uptake and distribution in the brain were demonstrable from the tenth minute after the oral administration of the labelled drug (average maximum uptake: 0.7% of the administered total dose). Brain distribution was heterogeneous (with preferences in the thalamus, basal ganglia and occipital cortex), similar to the distribution previously reported by the authors after intravenous administration.
Vinpocetine, administered orally to human volunteers, readily entered the bloodstream from the stomach and the gastrointestinal tract and thereafter passed the blood-brain barrier and entered the brain. Radioactivity from 11Cvinpocetine was also demonstrated in the kidneys and in urine. The study demonstrates that PET might be a useful, direct and non-invasive tool to study the distribution and pharmacokinetics of orally administered labelled drugs active in the central nervous system in the living human body.
Doktoravhandlinger ved NTNU Adam Judit , Norges teknisk-naturvitenskapelige universitet, Institutt for energi- og prosessteknikk
2005
Dissertation
Provider: - Institution: - Data provided by Europeana Collections- Judit Adam nå Judit Sandquist. Paper II is reprinted with kind permission from Elsevier, sciencedirect.com- Härtill 4 uppsatser- ...Diss. (sammanfattning) Trondheim : Norges teknisk-naturvitenskapelige universitet, 2005- PhD i energi- og prosessteknikk- PhD in Energy and Process Engineering- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
To demonstrate the importance of an extensively studied early nodulin gene ENOD12 in symbiotic nodule development, plants of different Medicago sativa subspecies were tested for the presence or ...absence of ENOD12 alleles. In M. s. ssp coerulea w2 (Mcw2), two ENOD12 genes were detected, whereas in M. s. ssp quasifalcata k93 (Mqk93) only one gene was present. In both plants, the ENOD12 genes were expressed in nodules induced by Rhizobium meliloti. The nucleotide sequence of the ENOD12 genes showed that the two Mcw2-specific genes were similar to the ENOD12A and ENOD12B genes of the tetraploid M. s. ssp sativa. ENOD12 from Mqk93 was similar to the corresponding gene found in M. truncatula. From the aligned ENOD12 sequences, an evolutionary tree was constructed. Genetic analysis of the progenies of a cross between Mqk93 and Mcw2 showed that several offspring in F1 carried a null allele originating from Mcw2, and among the F2 progenies, plants with the null allele only lacking the ENOD12 gene appeared. Surprisingly, the ENOD12-deficient plants were similar to their wild-type parents in viability, nodule development, nodule structure, and nitrogen fixation efficiency. Therefore, we concluded that in Medicago the ENOD12 gene is not required for symbiotic nitrogen fixation. Furthermore, we proposed that the heterozygous nature of these legumes can be exploited for the identification of mutated alleles of other known nodulin genes; this will permit the construction of plant mutants deficient in these genes.
Vinpocetine is a compound widely used in the prevention and treatment of cerebrovascular diseases. The exact mechanism of action of the drug is still not known. The objective of the present ...investigation was to determine the global uptake and regional distribution of radiolabelled vinpocetine in the human brain. Three healthy persons were examined with positron emission tomography (PET) and 11C-vinpocetine.
The uptake of 11C-vinpocetine in brain was rapid and on average as a maximum 3.7% of the total radioactivity injected was in the brain 2 minutes after radioligand administration. The uptake was heterogeneously distributed among brain regions. When compared with the cerebellum, an a priori reference region, the highest regional uptake was in the thalamus, the upper brain stem, the striatum and the cortex.
The brain regions showing increased uptake in the human brain correspond to those in which vinpocetine has previously been shown to induce elevated metabolism and blood flow by PET clinical studies in patients with chronic ischaemic post-stroke condition.
We relate two complexity notions of bipartite graphs: the minimal weight biclique covering number \(\mathrm{Cov}(G)\) and the minimal rectifier network size \(\mathrm{Rect}(G)\) of a bipartite graph ...\(G\). We show that there exist graphs with \(\mathrm{Cov}(G)\geq \mathrm{Rect}(G)^{3/2-\epsilon}\). As a corollary, we establish that there exist nondeterministic finite automata (NFAs) with \(\varepsilon\)-transitions, having \(n\) transitions total such that the smallest equivalent \(\varepsilon\)-free NFA has \(\Omega(n^{3/2-\epsilon})\) transitions. We also formulate a version of previous bounds for the weighted set cover problem and discuss its connections to giving upper bounds for the possible blow-up.
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