Languages show variations according to the social class of speakers and Latin was no exception, as readers of Petronius are aware. The Romance languages have traditionally been regarded as developing ...out of a 'language of the common people' (Vulgar Latin), but studies of modern languages demonstrate that linguistic change does not merely come, in the social sense, 'from below'. There is change from above, as prestige usages work their way down the social scale, and change may also occur across the social classes. This book is a history of many of the developments undergone by the Latin language as it changed into Romance, demonstrating the varying social levels at which change was initiated. About thirty topics are dealt with, many of them more systematically than ever before. Discussions often start in the early Republic with Plautus, and the book is as much about the literary language as about informal varieties.
Low molecular weight gels are formed by the self-assembly of small molecules into anisotropic structures that form a network capable of immobilizing the solvent. Such gels are common, with a huge ...number of different examples existing, and they have many applications. However, there are still significant gaps in our understanding of these systems and challenges that need to be addressed if we are to be able to fully design such systems. Here, a number of these challenges are discussed.
Since the 1980s, bilingualism has become one of the main themes of sociolinguistics - but there are as yet few large-scale treatments of the subject specific to the ancient world. This book is the ...first work to deal systematically with bilingualism during a period of antiquity (the Roman period, down to about the fourth century AD) in the light of sociolinguistic discussions of bilingual issues. The general theme of the work is the nature of the contact between Latin and numerous other languages spoken in the Roman world. Among the many issues discussed three are prominent: code-switching (the practice of switching between two languages in the course of a single utterance) and its motivation, language contact as a cause of change in one or both of the languages in contact, and the part played by language choice and language switching in the establishment of personal and group identities.
Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype ...'chronic pain grade', have been shown previously to be complex heritable traits with a polygenic component. Additional pain-related phenotypes capturing aspects of an individual's overall sensitivity to experiencing and reporting chronic pain have also been suggested as a focus for investigation. We made use of a measure of the number of sites of chronic pain in individuals within the UK general population. This measure, termed Multisite Chronic Pain (MCP), is a complex trait and its genetic architecture has not previously been investigated. To address this, we carried out a large-scale genome-wide association study (GWAS) of MCP in ~380,000 UK Biobank participants. Our findings were consistent with MCP having a significant polygenic component, with a Single Nucleotide Polymorphism (SNP) heritability of 10.2%. In total 76 independent lead SNPs at 39 risk loci were associated with MCP. Additional gene-level association analyses identified neurogenesis, synaptic plasticity, nervous system development, cell-cycle progression and apoptosis genes as enriched for genetic association with MCP. Genetic correlations were observed between MCP and a range of psychiatric, autoimmune and anthropometric traits, including major depressive disorder (MDD), asthma and Body Mass Index (BMI). Furthermore, in Mendelian randomisation (MR) analyses a causal effect of MCP on MDD was observed. Additionally, a polygenic risk score (PRS) for MCP was found to significantly predict chronic widespread pain (pain all over the body), indicating the existence of genetic variants contributing to both of these pain phenotypes. Overall, our findings support the proposition that chronic pain involves a strong nervous system component with implications for our understanding of the physiology of chronic pain. These discoveries may also inform the future development of novel treatment approaches.
Classical Latin appears to be without regional dialects, yet Latin evolved in little more than a millennium into a variety of different languages (the Romance languages: Italian, French, Spanish, ...Portuguese etc.). Was regional diversity apparent from the earliest times, obscured perhaps by the standardisation of writing, or did some catastrophic event in late antiquity cause the language to vary? These questions have long intrigued Latinists and Romance philologists, struck by the apparent uniformity of Latin alongside the variety of Romance. This book, first published in 2007, establishes that Latin was never geographically uniform. The changing patterns of diversity and the determinants of variation are examined from the time of the early inscriptions of Italy, through to late antiquity and the beginnings of the Romance dialects in the western Roman provinces. This is the most comprehensive treatment ever undertaken of the regional diversification of Latin throughout its history in the Roman period.
Impaired apoptosis is both critical in cancer development and a major barrier to effective treatment. In response to diverse intracellular damage signals, including those evoked by cancer therapy, ...the cell's decision to undergo apoptosis is determined by interactions between three factions of the Bcl-2 protein family. The damage signals are transduced by the diverse 'BH3-only' proteins, distinguished by the BH3 domain used to engage their pro-survival relatives: Bcl-2, Bcl-x(L), Bcl-w, Mcl-1 and A1. This interaction ablates pro-survival function and allows activation of Bax and Bak, which commit the cell to apoptosis by permeabilizing the outer membrane of the mitochondrion. Certain BH3-only proteins (e.g. Bim, Puma) can engage all the pro-survival proteins, but others (e.g. Bad, Noxa) engage only subsets. Activation of Bax and Bak appears to require that the BH3-only proteins engage the multiple pro-survival proteins guarding Bax and Bak, rather than binding to the latter. The balance between the pro-survival proteins and their BH3 ligands regulates tissue homeostasis, and either overexpression of a pro-survival family member or loss of a proapoptotic relative can be oncogenic. Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for "BH3 mimetics" as a novel class of anticancer drugs.
ABSTRACT
We utilize deep near-infrared survey data from the UltraVISTA fourth data release (DR4) and the VIDEO survey, in combination with overlapping optical and Spitzer data, to search for bright ...star-forming galaxies at z ≳ 7.5. Using a full photometric redshift fitting analysis applied to the ∼6 $\, {\rm deg}^2$ of imaging searched, we find 27 Lyman break galaxies (LBGs), including 20 new sources, with best-fitting photometric redshifts in the range 7.4 < z < 9.1. From this sample, we derive the rest-frame UV luminosity function at z = 8 and z = 9 out to extremely bright UV magnitudes (MUV ≃ −23) for the first time. We find an excess in the number density of bright galaxies in comparison to the typically assumed Schechter functional form derived from fainter samples. Combined with previous studies at lower redshift, our results show that there is little evolution in the number density of very bright (MUV ∼ −23) LBGs between z ≃ 5 and z ≃ 9. The tentative detection of an LBG with best-fitting photometric redshift of z = 10.9 ± 1.0 in our data is consistent with the derived evolution. We show that a double power-law fit with a brightening characteristic magnitude (ΔM*/Δz ≃ −0.5) and a steadily steepening bright-end slope (Δβ/Δz ≃ −0.5) provides a good description of the z > 5 data over a wide range in absolute UV magnitude (−23 < MUV < −17). We postulate that the observed evolution can be explained by a lack of mass quenching at very high redshifts in combination with increasing dust obscuration within the first ${\sim}1 \, {\rm Gyr}$ of galaxy evolution.
ABSTRACT
We present a reduction and analysis of the James Webb Space Telescope (JWST) SMACS 0723 field using new post-launch calibrations to conduct a search for ultra-high-redshift galaxies (z > 9) ...present within the Epoch of Reionization. We conduct this search by modelling photometric redshifts in several ways for all sources and by applying conservative magnitude cuts (mF200W < 28) to identify strong Lyman breaks greater than 1 mag. We find four z > 9 candidate galaxies which have not previously been identified, with one object at z = 11.5, and another which is possibly a close pair of galaxies. We measure redshifts for candidate galaxies from other studies and find the recovery rate to be only 23 per cent, with many being assigned lower redshift, dusty solutions in our work. Most of our z > 9 sample show evidence for Balmer-breaks, or extreme emission lines from H β and O iii, demonstrating that the stellar populations could be advanced in age or very young depending on the cause of the F444W excess. We discuss the resolved structures of these early galaxies and find that the Sérsic indices reveal a mixture of light concentration levels, but that the sizes of all our systems are exceptionally small (<0.5 kpc). These systems have stellar masses M* ∼ 109.0 M⊙, with our z ∼ 11.5 candidate a dwarf galaxy with a stellar mass M* ∼ 107.8–108.2 M⊙. These candidate ultra high-redshift galaxies are excellent targets for future NIRSpec observations aimed to better understand their physical nature.
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