Abstract
We present seven new transiting hot Jupiters from the WASP-South survey. The planets are all typical hot Jupiters orbiting stars from F4 to K0 with magnitudes of V = 10.3-12.5. The orbital ...periods are all in the range of 3.9-4.6 d, the planetary masses range from 0.4 to 2.3 M
Jup and the radii from 1.1 to 1.4 R
Jup. In line with known hot Jupiters, the planetary densities range from Jupiter-like to inflated (ρ = 0.13-1.07ρJup). We use the increasing numbers of known hot Jupiters to investigate the distribution of their orbital periods and the 3-4 d 'pile-up'.
Abstract
We present 75 near-infrared (NIR; 0.8−2.5
μ
m) spectra of 34 stripped-envelope core-collapse supernovae (SESNe) obtained by the Carnegie Supernova Project-II (CSP-II), encompassing optical ...spectroscopic Types IIb, Ib, Ic, and Ic-BL. The spectra range in phase from pre-maximum to 80 days past maximum. This unique data set constitutes the largest NIR spectroscopic sample of SESNe to date. NIR spectroscopy provides observables with additional information that is not available in the optical. Specifically, the NIR contains the strong lines of He
i
and allows a more detailed look at whether Type Ic supernovae are completely stripped of their outer He layer. The NIR spectra of SESNe have broad similarities, but closer examination through statistical means reveals a strong dichotomy between NIR “He-rich” and “He-poor” SNe. These NIR subgroups correspond almost perfectly to the optical IIb/Ib and Ic/Ic-BL types, respectively. The largest difference between the two groups is observed in the 2
μ
m region, near the He
i
λ
2.0581
μ
m line. The division between the two groups is
not
an arbitrary one along a continuous sequence. Early spectra of He-rich SESNe show much stronger He
i
λ
2.0581
μ
m absorption compared to the He-poor group, but with a wide range of profile shapes. The same line also provides evidence for trace amounts of He in half of our SNe in the He-poor group.
Clinical trials and meta-analyses have suggested that aspirin may be effective for the prevention of venous thromboembolism (proximal deep-vein thrombosis or pulmonary embolism) after total hip or ...total knee arthroplasty, but comparisons with direct oral anticoagulants are lacking for prophylaxis beyond hospital discharge.
We performed a multicenter, double-blind, randomized, controlled trial involving patients who were undergoing total hip or knee arthroplasty. All the patients received once-daily oral rivaroxaban (10 mg) until postoperative day 5 and then were randomly assigned to continue rivaroxaban or switch to aspirin (81 mg daily) for an additional 9 days after total knee arthroplasty or for 30 days after total hip arthroplasty. Patients were followed for 90 days for symptomatic venous thromboembolism (the primary effectiveness outcome) and bleeding complications, including major or clinically relevant nonmajor bleeding (the primary safety outcome).
A total of 3424 patients (1804 undergoing total hip arthroplasty and 1620 undergoing total knee arthroplasty) were enrolled in the trial. Venous thromboembolism occurred in 11 of 1707 patients (0.64%) in the aspirin group and in 12 of 1717 patients (0.70%) in the rivaroxaban group (difference, 0.06 percentage points; 95% confidence interval CI, -0.55 to 0.66; P<0.001 for noninferiority and P=0.84 for superiority). Major bleeding complications occurred in 8 patients (0.47%) in the aspirin group and in 5 (0.29%) in the rivaroxaban group (difference, 0.18 percentage points; 95% CI, -0.65 to 0.29; P=0.42). Clinically important bleeding occurred in 22 patients (1.29%) in the aspirin group and in 17 (0.99%) in the rivaroxaban group (difference, 0.30 percentage points; 95% CI, -1.07 to 0.47; P=0.43).
Among patients who received 5 days of rivaroxaban prophylaxis after total hip or total knee arthroplasty, extended prophylaxis with aspirin was not significantly different from rivaroxaban in the prevention of symptomatic venous thromboembolism. (Funded by the Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT01720108 .).
ABSTRACT Inverse Compton cooling limits the brightness temperature of the radiating plasma to a maximum of 1011.5 K. Relativistic boosting can increase its observed value, but apparent brightness ...temperatures much in excess of 1013 K are inaccessible using ground-based very long baseline interferometry (VLBI) at any wavelength. We present observations of the quasar 3C 273, made with the space VLBI mission RadioAstron on baselines up to 171,000 km, which directly reveal the presence of angular structure as small as 26 as (2.7 light months) and brightness temperature in excess of 1013 K. These measurements challenge our understanding of the non-thermal continuum emission in the vicinity of supermassive black holes and require a much higher Doppler factor than what is determined from jet apparent kinematics.
Little is known about adherence to inhaled medication in chronic obstructive pulmonary disease (COPD) and the impact on mortality and morbidity.
Data on drug adherence from a randomised double-blind ...trial comparing inhaled salmeterol 50 microg + fluticasone propionate 500 microg twice daily with placebo and each drug individually in 6112 patients with moderate to severe COPD over 3 years in the TORCH study were used. All-cause mortality and exacerbations leading to hospital admission were primary and secondary end points. The study of adherence was not specified a priori as an ancillary study.
Of the 4880 patients (79.8%) with good adherence defined as >80% use of study medication, 11.3% died compared with 26.4% of the 1232 patients (20.2%) with poor adherence. The annual rates of hospital admission for exacerbations were 0.15 and 0.27, respectively. The association between adherence and mortality remained unchanged and statistically significant after adjusting for other factors related to prognosis (hazard ratio 0.40 (95% CI 0.35 to 0.46), p<0.001). The association was even stronger when analysing on-treatment deaths only. Similarly, the association between adherence and hospital admission remained unchanged and significant in a multivariate analysis (rate ratio 0.58 (95% CI 0.44 to 0.73, p<0.001). The association between increased adherence and improved mortality and reduction in hospital admission was independent of study treatment. The effect of treatment was more pronounced in patients with good adherence than in those with poor adherence.
Adherence to inhaled medication is significantly associated with reduced risk of death and admission to hospital due to exacerbations in COPD. Further research is needed to understand these strong associations.
GRB 130427A was extremely bright as a result of occurring at low redshift whilst the energetics were more typical of high-redshift gamma-ray bursts (GRBs). We collected well-sampled light curves at ...1.4 and 4.8 GHz of GRB 130427A with the Westerbork Synthesis Radio Telescope (WSRT); and we obtained its most accurate position with the European Very Long Baseline Interferometry Network (EVN). Our flux density measurements are combined with all the data available at radio, optical and X-ray frequencies to perform broad-band modelling in the framework of a reverse–forward shock model and a two-component jet model, and we discuss the implications and limitations of both models. The low density inferred from the modelling implies that the GRB 130427A progenitor is either a very low metallicity Wolf–Rayet star, or a rapidly rotating, low-metallicity O star. We also find that the fraction of the energy in electrons is evolving over time, and that the fraction of electrons participating in a relativistic power-law energy distribution is less than 15 per cent. We observed intraday variability during the earliest WSRT observations, and the source sizes inferred from our modelling are consistent with this variability being due to interstellar scintillation effects. Finally, we present and discuss our limits on the linear and circular polarization, which are among the deepest limits of GRB radio polarization to date.
This paper presents one of the first environmental analyses of the locations of the class of ‘interacting transients’, namely Type IIn supernovae (SNe) and SN impostors. We discuss the association of ...these transients with star formation, host galaxy type, metallicity and the locations of each event within the respective host. Given the frequent assumption of very high mass progenitors for these explosions from various studies, most notably a direct progenitor detection, it is interesting to note the weak association of these subtypes with star formation as traced by Hα emission, particularly in comparison with Type Ic SNe, which trace the Hα emission and are thought to arise from high-mass progenitors. The radial distributions of these transients compared to Type Ic SNe are also very different. This provides evidence for the growing hypothesis that these ‘interacting transients’ are in fact comprised of a variety of progenitor systems. The events contained within this sample are discussed in detail, where information in the literature exists, and compared to the environmental data provided. Impostors are found to split into two main classes, in terms of environment: SN 2008S-like impostors fall on regions of zero Hα emission, whereas η Carina-like impostors all fall on regions with positive Hα emission. We also find indications that the impostor class originate from lower metallicity environments than Type IIn, Ic and IIP SNe.
ABSTRACT We present the first results of the High Cadence Transient Survey (HiTS), a survey for which the objective is to detect and follow-up optical transients with characteristic timescales from ...hours to days, especially the earliest hours of supernova (SN) explosions. HiTS uses the Dark Energy Camera and a custom pipeline for image subtraction, candidate filtering and candidate visualization, which runs in real-time to be able to react rapidly to the new transients. We discuss the survey design, the technical challenges associated with the real-time analysis of these large volumes of data and our first results. In our 2013, 2014, and 2015 campaigns, we detected more than 120 young SN candidates, but we did not find a clear signature from the short-lived SN shock breakouts (SBOs) originating after the core collapse of red supergiant stars, which was the initial science aim of this survey. Using the empirical distribution of limiting magnitudes from our observational campaigns, we measured the expected recovery fraction of randomly injected SN light curves, which included SBO optical peaks produced with models from Tominaga et al. (2011) and Nakar & Sari (2010). From this analysis, we cannot rule out the models from Tominaga et al. (2011) under any reasonable distributions of progenitor masses, but we can marginally rule out the brighter and longer-lived SBO models from Nakar & Sari (2010) under our best-guess distribution of progenitor masses. Finally, we highlight the implications of this work for future massive data sets produced by astronomical observatories, such as LSST.
Dysbiosis, defined as unhealthy shifts in bacterial community composition, can lower the colonization resistance of the gut to intrinsic pathogens. Here, we determined the effect of diet age and type ...on the health and bacterial community composition of the honeybee (Apis mellifera). We fed newly emerged bees fresh or aged diets, and then recorded host development and bacterial community composition from four distinct regions of the hosts’ digestive tract. Feeding fresh pollen or fresh substitute, we found no difference in host mortality, diet consumption, development or microbial community composition. In contrast, bees fed aged diets suffered impaired development, increased mortality and developed a significantly dysbiotic microbiome. The consumption of aged diets resulted in a significant reduction in the core ileum bacterium Snodgrassella alvi and a corresponding increase in intrinsic pathogen Frischella perrara. Moreover, the relative abundance of S. alvi in the ileum was positively correlated with host survival and development. The inverse was true for both F. perrara and Parasacharibacter apium. Collectively, our findings suggest that the early establishment of S. alvi is associated with healthy nurse development and potentially excludes F. perrara and P. apium from the ileum. Although at low abundance, establishment of the common midgut pathogen Nosema spp. was significantly associated with ileum dysbiosis and associated host deficiencies. Moreover, dysbiosis in the ileum was reflected in the rectum, mouthparts and hypopharyngeal glands, suggesting a systemic host effect. Our findings demonstrate that typically occurring alterations in diet quality play a significant role in colony health and the establishment of a dysbiotic gut microbiome.
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