In addition to exhibited antioxidant and anti-inflammatory activity, fullerene C60 is a promising wound healing agent. An important stage in the production of fullerene-based ointments is the ...stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).
As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution nanoclusters have a size of 6 nm and are assembled into agglomerates which reach a size of 150 nm.
The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.
The aqueous dispersion of fullerene C60 (AFD)–based ointment demonstrated a high wound healing activity on animal model. AFD produced by diafiltration in the presence of the biocompatible nonionic stabilizer Pluronic F-127. As estimated by small-angle neutron scattering and dynamic light scattering, AFD contains nanoparticles (~6 nm) with narrow size distribution formed branched aggregates up to 150 nm. Display omitted
We present a theoretical model of spin transitions in stacks of molecular layers. Our model captures the already established physics of these systems (thermal hysteretic transitions and crossovers) ...and suggests a way towards in situ control of this physics by means of an external electric field. Our results pave the way toward both temperature and voltage controllable organic memory.
The effect of barothermal (HPHT) treatment on the structure and properties of carbides of refractory metals and their alloys is considered. The principal directions of studies are determined. The ...comparative analysis of data measured in studying the mechanical properties of WC–Co hard alloys after sintering at high pressures and temperatures is performed. It has been established that the crucial role in the formation of the structure and mechanical properties of WC–Co alloys in the process of HPHT treatment is played by the process temperature under constant pressure conditions.
The organization of promoters of DREB2B TF ortholog genes involved in the response to abiotic stresses was studied in
D. antarctica
E. Desv. extremophile plant and 12 more grass species with ...different cold and drought resistance. The evolutionary distances between the sequences of promoters were 0.621 on average, those between coding sequences (including introns) were 0.442, and the values of nucleotide diversity (π) for these regions were 0.410 and 0.274, respectively. Clustering of sequences corresponded in general to the accepted systematic division of the Poaceae family into subfamilies. Fifty-four
cis
-elements involved in the response to abiotic and biotic stresses, light, hormones (particularly, abscisic acid, auxin, methyl jasmonate, ethylene, gibberellin, and salicylic acid), and tissue-specific
cis
-elements were identified. Most of the
cis
-elements were associated with the response to abiotic stress that is consistent with data on DREB2B TF functions. Except for single peculiarities, representatives of different grass subfamilies and
D. antarctica
were similar in the total set of
cis
-elements in the
DREB2B
promoter that indicates the similarity of the regulation of expression of this gene and its potential functions in the response to stress in the studied species.
The intergenic spacer (IGS) of 5S ribosomal RNA genes (5S rDNA) (that are present in the genome of all living organisms) is characterized by a high variability, due to which it is a convenient and ...widely used object for clarifying the issues of genome evolution, population genetics, systematics, etc. The aim of this work was to study the IGS of 5S rDNA of the Antarctic pearlwort
Colobanthus quitensis
. The nucleotide sequence was determined by the methods of molecular genetic analysis, and molecular organization of the
C. quitensis
5S rDNA IGS was studied. It was demonstrated that it contains the regulatory elements typical for other vascular plants. The existence of at least two classes of 5S rDNA repeats in the individual genome (that differ significantly in the length and nucleotide sequence of IGS) was established. In addition, based on differences in the length and nucleotide sequence, two subclasses of repeats with a long IGS and three subclasses with a short IGS were identified. A comparison of 5S rDNA IGS sequences in
C. quitensis
and
Silene latifolia
Poir. (a member of another section of the Caryophyllaceae family) demonstrated significant differences in the structure of a spacer region of 5S rRNA genes (except for its parts containing regulatory elements). In general, data obtained indicate a significant level of intragenomic polymorphism of
C. quitensis
5S rDNA IGS.
The paper lists the main objectives of the scientific complex of the landing platform of the ExoMars-2018 mission. Scientific instruments of the complex are described including the meteorological ...complex, Fourier spectrometer, radiothermometer, Martian gas analytical complex, dust complex, seismometer, etc. The main studies and results that will be obtained using this scientific equipment are presented.
Spectrum transformation of a chirped Ti:sapphire laser pulse stretched to 0.2 ns (initial duration of a transform-limited pulse of 90 fs) was experimentally studied in a tandem of BaWO
4
crystals. To ...increase stimulated Raman scattering efficiency, broadband laser emission was used as a seed of this process. Efficiency of the Stokes component generation corresponding to the BaWO
4
crystal phonon mode
ν
1
(A
g
) ≈ 925 cm
–1
reached ~10%. Generation of the Stokes component corresponding to the weaker phonon mode
ν
3
(E
g
) ≈ 795 cm
–1
and second Stokes components of
ν
1
(A
g
) and
ν
3
(E
g
) modes was observed. Mechanisms reducing the stimulated Raman scattering efficiency for the
ν
1
(A
g
) mode are discussed.
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