We present an analysis of eight years of Fermi-LAT (>0.1 GeV) γ-ray data obtained for the radio galaxy NGC 1275. The γ-ray flux from NGC 1275 is highly variable on short (∼days to weeks) timescales, ...and has steadily increased over this eight year timespan. By examining the changes in its flux and spectral shape in the LAT energy band over the entire data set, we found that its spectral behavior changed around 2011 February (∼MJD 55600). The γ-ray spectra at early times evolved largely at high energies, while the photon indices were unchanged at later times despite rather large flux variations. To explain these observations, we suggest that the flux changes at the early times were caused by injection of high-energy electrons into the jet while, later, the γ-ray flares were caused by a changing Doppler factor owing to variations in the jet Lorentz factor and/or changes in the angle to our line of sight. To demonstrate the viability of these scenarios, we fit the broad band spectral energy distribution data with a one-zone synchrotron self-Compton (SSC) model for flaring and quiescent intervals before and after 2011 February. To explain the γ-ray spectral behavior in the context of the SSC model, the maximum electron Lorentz factor would have changed at the early times, while a modest change in the Doppler factor adequately fits the quiescent and flaring state γ-ray spectra at the later times.
Long duration gamma-ray bursts may serve as standard candles to constrain cosmological parameters by probing the Hubble diagram well beyond the range of redshift currently accessible using SNe Ia. ...The standardization of gamma-ray bursts (GRBs) is based on phenomenological relations between two or more parameters found from spectral modeling, one of which is strongly dependent on the cosmological model. The Amati relation links the source-frame energy at which the prompt gamma-ray spectral energy distribution F peaks, and the isotropic-equivalent bolometric energy emitted during the prompt phase. We performed spectral analysis of 26 GRBs with known redshift that have been detected by the Fermi-Large Area Telescope (LAT) during its nine years of operations from 2008 July to 2017 September, thus extending the computation of Eiso to the 100 MeV range. Multiple components are required to fit the spectra of a number of GRBs. We found that the Amati relation is satisfied by the 25 LGRBs, with best-fit parameters similar to previous studies that used data from different satellite experiments, while the only short GRB with known redshift is an outlier. Using the Amati relation, we extend the Hubble diagram to redshift 4.35 and constrain the Hubble constant and dark-energy density in the ΛCDM model, with Fermi-LAT GRBs alone and together with another sample of 94 GRBs and with the latest Supernovae type-Ia data. Our results are consistent with the currently acceptable ranges of those cosmological parameters within errors.
X-ray computed tomography (CT) is widely used in diagnostic imaging. Owing to a strong radiation exposure associated with this method, numerous proposals have been made for reducing the radiation ...dose. In addition, conventional CT does not provide information on the energy associated with each X-ray photon because intensity is rather high, typically amounts to 107−9cps/mm2. Here, we propose a novel, low-dose photon-counting CT system based on a multi-pixel photon counter (MPPC) and a high-speed scintillator. To demonstrate high signal-to-noise ratio utilizing the internal gain and the fast time response of the MPPC, we compared CT images acquired under the same conditions among a photodiode (PD), an avalanche photodiode and a MPPC. In particular, the images' contrast-to-noise ratio (CNR) acquired using the MPPC improved 12.6-fold compared with the images acquired in conventional CT using a PD. We also performed energy-resolved imaging by adopting 4 energy thresholds of 20, 40, 60, and 80keV. We confirmed a substantial improvement of the imaging contrast as well as a reduction in the beam hardening for the CT images. We conclude that the proposed MPPC-based detector is likely to be a promising device for use in future CT scanners.
X-ray computed tomography (CT) has been widely used in the diagnostic imaging of the interior of the human body. However, the radiation dose of conventional CT typically amounts to 10 mSv. Under such ...environments, X-ray photons are severely piled-up; therefore, conventional CT acquires energy integrated images, and artifacts are formed by beam hardening. In contrast, a photon counting CT (PC-CT) system is anticipated to construct a low-dose and multi-color CT system. Recently, we proposed a novel PC-CT system using a multipixel photon counter (MPPC) coupled with a high-speed scintillator, which is cost effective and easy to assemble compared to other methods using CdZnTe device. In this paper, we report the results using an advanced CT system consisting of a 16-channel MPPC and scintillator array coupled with a newly developed large-scale integrated circuit (LSI) having an ultrafast signal processing capability. We present the performance of the photon-counting CT capability, such as the contrast of the obtained CT images compared with that of the current-mode CT, and we found that substantial reduction in radiation dose by an order of magnitude. In addition, we report the results of three-dimensional multicolor imaging to identify phantom materials.
Photon-counting computed tomography (PC-CT) has attracted attention over the last few years as the next-generation CT technique that solves the problems encountered in clinical CT. In PC-CT, dark ...current and electronic noise can be reduced by setting the energy threshold to exceed the noise level, which leads to a low-dose scan. Furthermore, multiple energy thresholds realize multicolor CT imaging, which is not possible with clinical CT. Recently, we proposed a novel PC-CT system consisting of a multipixel photon counter (MPPC) coupled with a high-speed scintillator, performing simultaneous imaging of multiple contrast agents and estimate concentration. However, the PC-CT images obtained by our PC-CT system faces some limitations, such as degradation of image quality due to the lack of photon statistics and/or image resolution loss due to the pixel size of the detectors. In this study, the signal-to-noise ratio (SNR) of the PC-CT images was improved by applying machine-learning models, that is, U-Net and Noise2Noise, to the PC-CT images. In addition, a new imaging method was developed to acquire the high-resolution CT images required for clinical use. As a result, the resolution of the CT images improved from 1.04 mm to 0.77 mm. Finally, the visualization of contrast agents in plants was set as a challenge for the next step towards the clinical application of MPPC-based PC-CT. The results demonstrate that our PC-CT system can provide color imaging not only in phantom-based experiments, but also in plants close to an organism.
X-ray computed tomography (CT) is widely used for non-invasive diagnostic imaging of the inside of the human body. It should be noted that the approximate effective radiation dose in a patient is 10 ...mSv. Under such an environment, X-ray photons are severely piled-up. Therefore, conventional CT only reconstructs energy integrated image, which may consist of beam hardening artifacts that have proven to be a problem. In contrast, photon counting CT (PC-CT) offers a low-dose multicolor CT imaging. The PC-CT also enables K-edge imaging that can improve the blood–tissue contrast using specific contrast agents. Moreover, the PC-CT has great advantages in (1) the simultaneous imaging of multiple contrast agents, and (2) the absolute quantification of contrast agents. Owing to these advantages, the PC-CT system can provide more detailed tissue diagnosis than conventional CT systems. Recently, we proposed a novel PC-CT system (Morita et al., 2017; Arimoto et al., 2017, Maruhashi et al., 2018) consisting of multipixel photon counter (MPPC) coupled with a high-speed scintillator, which is a cost-effective and easy to assemble system, as compared to other PC-CT devices based on cadmium zinc telluride. In this paper, we operated the K-edge imaging of specific contrast agents using a 16-channel MPPC PC-CT system. Our PC-CT system established appropriate energy thresholds and operated the simultaneous imaging of multiple contrast agents such as iodine and gadolinium. In addition, we estimated the absolute concentration of these contrast agents. The results show that our PC-CT system can provide more accurate diagnostic medical imaging, as compared to the conventional CT system.
X-ray computed tomography (CT) is a widely used diagnostic tool to visualize the interior of the human body. However, the exposure dose of conventional CT in a single scan is large, typically 10 mSv, ...and therefore, it is necessary to find ways to reduce the radiation dose. Furthermore, conventional CT does not contain the energy information of individual X-ray photons because the X-ray signals are read out as an integrated form. This causes misidentification of materials. To resolve this issue, we propose a novel photon counting CT (PC-CT) system consisting of multi-pixel photon counters (MPPCs) coupled with high speed scintillators. The system has a 64-channel MPPC array that improves energy information and wide-area imaging. By fine energy adjustment and increasing the number of energy thresholds to six, which were newly implemented in the 64-channel PC-CT system, we succeeded in accurately estimating the concentrations of contrast agents such as iodine and gadolinium. Moreover, for mixed phantoms of iodine and gadolinium, we demonstrate discrimination between them, and estimate the concentrations individually, which cannot be done by conventional CTs. This shows great potential in expanding the applications of X-ray CTs.
Open Educational Resources have emerged as important elements of education in the contemporary society, promoting life-long and personalized learning that transcends social, economic and geographical ...barriers. To achieve the potential of OERs and bring impact on education, it is necessary to increase their development and supply. However, one of the current challenges is how to produce quality and relevant OERs to be reused and adapted to different contexts and learning situations. In this paper we proposed an agile method for the development of OERs - AM-OER, grounded on agile practices from Software Engineering. Learning Design practices from the OULDI project (UK Open University) are also embedded into the AM-OER aiming at improving quality and facilitating reuse and adaptation of OERs. In order to validate AM-OER, an experiment was conducted by applying it in the development of an OER on software testing. The results showed preliminary evidences on the applicability, effectiveness and efficiency of the method in the development of OERs.
We have measured the linear polarization of hard X-ray emission from the Crab in a previously unexplored energy interval, 20–120 keV. The introduction of two new observational parameters, the ...polarization fraction and angle stands to disentangle geometrical and physical effects, thereby providing information on the pulsar wind geometry and magnetic field environment. Measurements are conducted using the PoGOLite Pathfinder – a balloon-borne polarimeter. Polarization is determined by measuring the azimuthal Compton scattering angle of incident X-rays in an array of plastic scintillators housed in an anticoincidence well. The polarimetric response has been characterized prior to flight using both polarized and unpolarized calibration sources. We address possible systematic effects through observations of a background field. The measured polarization fraction for the integrated Crab light curve is
$18.4^{+9.8}_{-10.6}$
per cent, corresponding to an upper limit (99 per cent credibility) of 42.4 per cent, for a polarization angle of (149.2 ± 16.0)°.
Neuronal plasticity is regulated by the ovarian steroids estradiol (E2) and progesterone (P4) in many normal brain functions, as well as in acute response to injury and chronic neurodegenerative ...disease. In a female rat model of axotomy, the E2-dependent compensatory neuronal sprouting is antagonized by P4. To resolve complex glial-neuronal cell interactions, we used the “wounding-in-a-dish” model of neurons cocultured with astrocytes or mixed glia (microglia to astrocytes, 1:3). Although both astrocytes and mixed glia supported E2-enhanced neurite outgrowth, P4 antagonized E2-induced neurite outgrowth only with mixed glia, but not astrocytes alone. We now show that P4-E2 antagonism of neurite outgrowth is mediated by microglial expression of progesterone receptor (Pgr) membrane component 1 (Pgrmc1)/S2R, a putative nonclassical Pgr mediator with multiple functions. The P4-E2 antagonism of neurite outgrowth was restored by add-back of microglia to astrocyte-neuron cocultures. Because microglia do not express the classical Pgr, we examined the role of Pgrmc1, which is expressed in microglia in vitro and in vivo. Knockdown by siRNA-Pgrmc1 in microglia before add-back to astrocyte-neuron cocultures suppressed the P4-E2 antagonism of neurite outgrowth. Conditioned media from microglia restored the P4-E2 activity, but only if microglia were activated by lipopolysaccharide or by wounding. Moreover, the microglial activation was blocked by Pgmrc1-siRNA knockdown. These findings explain why nonwounded cultures without microglial activation lack P4 antagonism of E2-induced neurite outgrowth. We suggest that microglial activation may influence brain responses to exogenous P4, which is a prospective therapy in traumatic brain injury.
PDF
