Telemonitoring involves remotely monitoring patients' vital signs. It is an innovative and promising development in the care of people with heart failure that may reduce hospital admissions and the ...burden on the NHS, as well as improve patients' quality of life and clinical outcomes. This article describes what telemonitoring is and explores the evidence base for its use. The role of the nurse in telemonitoring is also discussed, with particular reference to dealing with and responding to alerts. The development and implementation of new technology is essential to improve the delivery of healthcare and optimise patient outcomes, and telemonitoring may play an important role in the future of heart failure services.
Although reports have shown shifts in carbon dot emission wavelengths resulting from varying the excitation wavelength, this excitation‐dependent emission does not constitute true tuning, as the ...shifted peaks have much weaker intensity than their dominant emission, and this is often undesired in real world applications. We report for the first time the synthesis and photoluminescence properties of carbon dots whose peak fluorescence emission wavelengths are tunable across the entire visible spectrum by simple adjustment of the reagents and synthesis conditions, and these carbon dots are excited by white light. Detailed material characterization has revealed that this tunable emission results from changes in the carbon dots’ chemical composition, dictated by dehydrogenation reactions occurring during carbonization. These significantly alter the nucleation and growth process, resulting in dots with either more oxygen‐containing or nitrogen‐containing groups that ultimately determine their photoluminescence properties, which is in stark contrast to previous observations of carbon dot excitation‐dependent fluorescence. This new ability to synthesize broadband excitable carbon dots with tunable peak emissions opens up many new possibilities, particularly in multimodal sensing, in which multiple analytes and processes could be monitored simultaneously by associating a particular carbon dot emission wavelength to a specific chemical process without the need for tuning the excitation source.
Farbabstimmung: Kohlenstoffpunkte, deren Fluoreszenzemissionswellenlängen über das gesamte sichtbare Spektrum von 400 bis 700 nm einstellbar sind, wurden durch einfache Anpassung der Reagentien und Synthesebedingungen hergestellt. Auf die Bestrahlung mit weißem Licht hin zeigen sie eine mehrfarbige Emission.
The original version of this Article contained errors in the author affiliations. Affiliation 1 incorrectly read 'School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW ...2031, Australia' and affiliation 4 incorrectly read 'School of Engineering, RMIT University, Melbourne, VIC 3001, Australia.' This has now been corrected in both the PDF and HTML versions of the Article.
Negative carbon emission technologies are critical for ensuring a future stable climate. However, the gaseous state of CO
does render the indefinite storage of this greenhouse gas challenging. ...Herein, we created a liquid metal electrocatalyst that contains metallic elemental cerium nanoparticles, which facilitates the electrochemical reduction of CO
to layered solid carbonaceous species, at a low onset potential of -310 mV vs CO
/C. We exploited the formation of a cerium oxide catalyst at the liquid metal/electrolyte interface, which together with cerium nanoparticles, promoted the room temperature reduction of CO
. Due to the inhibition of van der Waals adhesion at the liquid interface, the electrode was remarkably resistant to deactivation via coking caused by solid carbonaceous species. The as-produced solid carbonaceous materials could be utilised for the fabrication of high-performance capacitor electrodes. Overall, this liquid metal enabled electrocatalytic process at room temperature may result in a viable negative emission technology.
ObjectiveAcute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial ...infarction (MI) in a single institution using several different strategies.MethodsThe Hull and East Yorkshire Hospitals serve a population of ∼560 000. Patients admitted with ACS to cardiology or general medical wards were identified prospectively by trained nurses during 2005. Patients with a death or discharge code of MI were also identified by the hospital information department and, independently, from Myocardial Infarction National Audit Project (MINAP) records. The hospital laboratory identified all patients with an elevated serum troponin-T (TnT) by contemporary criteria (>0.03 µg/L in 2005).ResultsThe prospective survey identified 1731 admissions (1439 patients) with ACS, including 764 admissions (704 patients) with MIs. The hospital information department reported only 552 admissions (544 patients) with MI and only 206 admissions (203 patients) were reported to the MINAP. Using all 3 strategies, 934 admissions (873 patients) for MI were identified, for which TnT was >1 µg/L in 443, 0.04–1.0 µg/L in 435, ≤0.03 µg/L in 19 and not recorded in 37. A further 823 patients had TnT >0.03 µg/L, but did not have ACS ascertained by any survey method. Of the 873 patients with MI, 146 (16.7%) died during admission and 218 (25.0%) by 1 year, but ranging from 9% for patients enrolled in the MINAP to 27% for those identified by the hospital information department.ConclusionsMINAP and hospital statistics grossly underestimated the incidence of MI managed by our hospital. The 1-year mortality was highly dependent on the method of ascertainment.
L'ingresso alia gioventù di Claudio Nerone (music: Antonio Giannettini, libretto: Giambattista Neri) was commissioned by Duke Francesco II d'Este for the formal entrance of his bride, Princess ...Margherita Farnese, into Modena on 9 November 1692. Set against a tense political environment that centred around issues of succession and government, this lavish gala production represented a statement of propagandist display and conspicuous 'court' celebration given in the somewhat contradictory context of the 'public' Teatro Fontanelli before honoured guests and an 'upper'-class ticket-buying public. In 1685, Duke Francesco had effectively contracted out opera in Modena to this privately-run theatre. While L'ingresso appeared to represent the culmination of this strategy, its indulgent extravagance seemingly caused the huge loss on production. Opera under Francesco came to an abrupt end. L'ingresso has since lain virtually untouched by musicologists; and while there have been a number of valuable studies into music under the duke (most noticeably with regard to oratorio, cantata, and instrumental music), there has been no in-depth study of opera. This thesis seeks to rectify this oversight by reporting upon opera production under Duke Francesco through a review of the Teatro Fontanelli archives, and a full reconstruction and audit of the L 'ingresso financial accounts. These not only offer an extraordinary insight into the administration and staging of L 'ingresso (and the cause of the loss suffered), but also identify the existence of a mutually beneficial policy that delivered opera for Francesco against a seemingly autonomous and potentially profitable Teatro Fontanelli through an accounting system which protected the impresario from his losses and liabilities on production. L 'ingresso thus presents a rare opportunity to document the mechanisms of opera patronage and production under Duke Francesco II d'Este, and to provide a valuable insight into the reality of provincial Italian opera towards the end of the seventeenth century.
L'ingresso alia gioventù di Claudio Nerone (music: Antonio Giannettini, libretto: Giambattista Neri) was commissioned by Duke Francesco II d'Este for the formal entrance of his bride, Princess ...Margherita Farnese, into Modena on 9 November 1692. Set against a tense political environment that centred around issues of succession and government, this lavish gala production represented a statement of propagandist display and conspicuous 'court' celebration given in the somewhat contradictory context of the 'public' Teatro Fontanelli before honoured guests and an 'upper'-class ticket-buying public. In 1685, Duke Francesco had effectively contracted out opera in Modena to this privately-run theatre. While L'ingresso appeared to represent the culmination of this strategy, its indulgent extravagance seemingly caused the huge loss on production. Opera under Francesco came to an abrupt end. L'ingresso has since lain virtually untouched by musicologists; and while there have been a number of valuable studies into music under the duke (most noticeably with regard to oratorio, cantata, and instrumental music), there has been no in-depth study of opera. This thesis seeks to rectify this oversight by reporting upon opera production under Duke Francesco through a review of the Teatro Fontanelli archives, and a full reconstruction and audit of the L 'ingresso financial accounts. These not only offer an extraordinary insight into the administration and staging of L 'ingresso (and the cause of the loss suffered), but also identify the existence of a mutually beneficial policy that delivered opera for Francesco against a seemingly autonomous and potentially profitable Teatro Fontanelli through an accounting system which protected the impresario from his losses and liabilities on production. L 'ingresso thus presents a rare opportunity to document the mechanisms of opera patronage and production under Duke Francesco II d'Este, and to provide a valuable insight into the reality of provincial Italian opera towards the end of the seventeenth century.
Intronic expansion of a hexanucleotide GGGGCC repeat in the chromosome 9 open reading frame 72 (C9ORF72) gene is the major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal ...dementia. However, the cellular function of the C9ORF72 protein remains unknown. Here, we demonstrate that C9ORF72 regulates endosomal trafficking. C9ORF72 colocalized with Rab proteins implicated in autophagy and endocytic transport: Rab1, Rab5, Rab7 and Rab11 in neuronal cell lines, primary cortical neurons and human spinal cord motor neurons, consistent with previous predictions that C9ORF72 bears Rab guanine exchange factor activity. Consistent with this notion, C9ORF72 was present in the extracellular space and as cytoplasmic vesicles. Depletion of C9ORF72 using siRNA inhibited transport of Shiga toxin from the plasma membrane to Golgi apparatus, internalization of TrkB receptor and altered the ratio of autophagosome marker light chain 3 (LC3) II:LC3I, indicating that C9ORF72 regulates endocytosis and autophagy. C9ORF72 also colocalized with ubiquilin-2 and LC3-positive vesicles, and co-migrated with lysosome-stained vesicles in neuronal cell lines, providing further evidence that C9ORF72 regulates autophagy. Investigation of proteins interacting with C9ORF72 using mass spectrometry identified other proteins implicated in ALS; ubiquilin-2 and heterogeneous nuclear ribonucleoproteins, hnRNPA2/B1 and hnRNPA1, and actin. Treatment of cells overexpressing C9ORF72 with proteasome inhibitors induced the formation of stress granules positive for hnRNPA1 and hnRNPA2/B1. Immunohistochemistry of C9ORF72 ALS patient motor neurons revealed increased colocalization between C9ORF72 and Rab7 and Rab11 compared with controls, suggesting possible dysregulation of trafficking in patients bearing the C9ORF72 repeat expansion. Hence, this study identifies a role for C9ORF72 in Rab-mediated cellular trafficking.
PDF
