The velocity of a ˜3GeV neutrino beam is measured by comparing detection times at the near and far detectors of the MINOS experiment, separated by 734 km. A total of 473 far detector neutrino events ...was used to measure (v-c)/c=5.1±2.9×10-5 (at 68% C.L.). By correlating the measured energies of 258 charged-current neutrino events to their arrival times at the far detector, a limit is imposed on the neutrino mass of mν<50MeV/c2 (99% C.L.).
BURKITT LYMPHOMA IN A PEDIATRIC PATIENT: A CASE REPORT BOESEL, PAULINA SCHMIDT; CURVELO, JOSE ALEXANDRE DA ROCHA; OLIVEIRA, JOSIANE PEREIRA DE ...
Oral surgery, oral medicine, oral pathology and oral radiology,
September 2020, 2020-09-00, Letnik:
130, Številka:
3
Journal Article
Recenzirano
Burkitt lymphoma (BL) is a very rare non-Hodgkin lymphoma with extremely short doubling time that tends to affect children in the jaws. Here we report the case of a 6-year-old male patient who ...attended emergency service because of jaw pain, swelling, and dental mobility for 20 days. Biopsy was performed, and the diagnosis of BL was established. The patient was immediately admitted at the oncohematology center of a pediatric institute for treatment onset. Admission examination revealed generalized lymphadenopathy, sagittal sinus thrombosis, and multiple tumoral infiltration in sphenoidal and maxillary sinuses, liver, lung, kidneys, pancreas, and spinal canal. Treatment was established according to NHL-BFM-95 protocol, and currently the patient is in complete remission without signs of disease. This report demonstrates that rapid and precise diagnosis associated with the immediate onset of treatment was essential for the successful evolution of the patient and should be considered determinant for the prognosis of BL.
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent condition with cardiovascular and neurocognitive consequences. The alteration is the collapse of the upper airways during ...sleep, with consequent hypoxemia and hypercapnia, requiring a respiratory effort to reverse it. This leads to awakening, with the muscle contractions opening the airway followed by a period of hyperventilation. Sleep returns collapsing of the airway and restarting the cycle. Surgical procedures aiming increasing the airspace have been used, and orthognathic surgery has been indicated in more severe cases. This study presents a report of an OSAHS treatment through maxillomandibular advancement surgery. A 47-year-old patient with apnea-hypopnea index of 53.3 was submitted to previous septoplasty and uvulopalatopharyngoplasty without satisfactory results. The final treatment was maxillomandibular advancement surgery with excellent outcome and life quality improvement.
The increase in asthma and allergies has been attributed to declining exposure to environmental microorganisms. The main source of these is soil, the composition of which varies geographically and ...which is a major component (40–45%) of household dust. Our hypothesis-generating study aimed to investigate associations between soil components, respiratory health and allergy in a Scottish birth cohort. The cohort was recruited in utero in 1997/8, and followed up at one, two and five years for the development of wheezing, asthma and eczema. Lung function, exhaled nitric oxide and allergic sensitization were measured at age five in a subset. The Scottish Soils Database held at The James Hutton Institute was linked to the birth cohort data by the residential postcode at birth and five years. The soil database contained information on size separates, organic matter concentration, pH and a range of inorganic elements. Soil and clinical outcome data were available for 869, 790 and 727 children at one, two and five years. Three hundred and fifty nine (35%) of children had the same address at birth and five years. No associations were found between childhood outcomes and soil content in the residential area at age five. The soil silt content (2–20μm particle size) of the residential area at birth was associated with childhood wheeze (adjusted OR 1.20, 95% CI 1.05; 1.37), wheeze without a cold (1.41 1.18; 1.69), doctor-diagnosed asthma (1.54 1.04; 2.28), lung function (FEV1: beta −0.025 −0.047;−0.001) and airway inflammation (FENO: beta 0.15 0.03; 0.27) at age five, but not with allergic status or eczema. Whilst residual confounding is the most likely explanation for the associations reported, the results of this study lead us to hypothesise that early life exposure to residential soil silt may adversely influence childhood respiratory health, possibly because of the organic components of silt.
•We have linked a birth cohort with the Scottish Soils Database.•We have looked for associations between asthma, allergy and soil content.•No associations found for soil content at residence at age 5years.•Silt content at birth residence adversely linked with respiratory health up to age 5.•Early life exposure to soil silt may adversely influence childhood respiratory health.
We report on the strategy used to optimize the sensitivity of our search for a neutron electric dipole moment at the Paul Scherrer Institute. Measurements were made upon ultracold neutrons stored ...within a single chamber at the heart of our apparatus. A mercury cohabiting magnetometer together with an array of cesium magnetometers were used to monitor the magnetic field, which was controlled and shaped by a series of precision field coils. In addition to details of the setup itself, we describe the chosen path to realize an appropriate balance between achieving the highest statistical sensitivity alongside the necessary control on systematic effects. The resulting irreducible sensitivity is better than 1 × 10
−26
e
cm. This contribution summarizes in a single coherent picture the results of the most recent publications of the collaboration.
Can We Defy Nature's End? Pimm, Stuart L.; Ayres, Márcio; Balmford, Andrew ...
Science (American Association for the Advancement of Science),
09/2001, Letnik:
293, Številka:
5538
Journal Article
Recenzirano
Pimm et al raise questions regarding the enforceability of measures to protect natural ecosystems and prevent extinctions. Across several human generations, a transition to sustainable use of natural ...resources is essential, and biodiversity must be protected in the interim.
Salmonella enterica serovar Kentucky has become the most frequently isolated serovar from poultry in the United States over the past decade. Despite its prevalence in poultry, it causes few human ...illnesses in the United States. The dominance of S. Kentucky in poultry does not appear to be due to single introduction of a clonal strain, and its reduced virulence appears to correlate with the absence of virulence genes grvA, sseI, sopE, and sodC1. S. Kentucky's prevalence in poultry is possibly attributable to its metabolic adaptation to the chicken cecum. While there were no difference in the growth rate of S. Kentucky and S. Typhimurium grown microaerophilically in cecal contents, S. Kentucky persisted longer when chickens were coinfected with S. Typhimurium. The in vivo advantage that S. Kentucky has over S. Typhimurium appears to be due to differential regulation of core Salmonella genes via the stationary-phase sigma factor rpoS. Microarray analysis of Salmonella grown in cecal contents in vitro identified several metabolic genes and motility and adherence genes that are differentially activated in S. Kentucky. The contributions of four of these operons (mgl, prp, nar, and csg) to Salmonella colonization in chickens were assessed. Deletion of mgl and csg reduced S. Kentucky persistence in competition studies in chickens infected with wild-type or mutant strains. Subtle mutations affecting differential regulation of core Salmonella genes appear to be important in Salmonella's adaptation to its animal host and especially for S. Kentucky's emergence as the dominant serovar in poultry.
Electrospinning can be used to selectively process a variety of natural and synthetic polymers into highly porous scaffolds composed of nano-to-m diameter fibers. This process shows great potential ...as a gateway to the development of physiologically relevant tissue engineering scaffolds. In this study, we examine how incremental changes in fiber alignment modulate the material properties of a model scaffold. We prepared electrospun scaffolds of gelatin composed of varying fiber diameters and degrees of anisotropy. The scaffolds were cut into a series of “dog-bone” shaped samples in the longitudinal, perpendicular and transverse orientations and the relative degree of fiber alignment, as measured by the fast Fourier transform (FFT) method, was determined for each sample. We measured peak stress, peak strain and the modulus of elasticity as a function of fiber diameter and scaffold anisotropy. Fiber alignment was the variable most closely associated with the regulation of peak stress, peak strain and modulus of elasticity. Incremental changes, as judged by the FFT method, in the proportion of fibers that were aligned along a specific axis induced incremental changes in peak stress in the model scaffolds. These results underscore the critical role that scaffold anisotropy plays in establishing the material properties of an electrospun tissue engineering scaffold and the native extracellular matrix.
Strange metals exhibit a variety of anomalous magnetotransport properties, the most striking of which is a resistivity that increases linearly with magnetic field B over a broad temperature and field ...range. The ubiquity of this behavior across a spectrum of correlated metals—both single- and multiband, with either dominant spin and/or charge fluctuations, of varying levels of disorder or inhomogeneity, and in proximity to a quantum critical point or phase—obligates the search for a fundamental underlying principle that is independent of the specifics of any material. Strongly anisotropic (momentum-dependent) scattering can generate B-linear magnetoresistance but only at intermediate field strengths. At high enough fields, the magnetoresistance must eventually saturate. Here, we consider the ultimate limit of such anisotropy, a region or regions on the Fermi surface that impede all orbital (cyclotron) motion through them, but whose imposition can be modelled nonetheless through a modified Boltzmann theoretical treatment. Application of the proposed theorem suggests that the realization of quadratic-to-linear magnetoresistance requires the presence of a bounded sector on the Fermi surface possibly separating two distinct types of carriers. While this bounded sector may have different origins or manifestations, we expect its existence to account for the anomalous magnetotransport found in a wide range of correlated materials.
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