An exhaustive validation of some of the operational ocean forecast products available in the Gibraltar Strait and the Alboran Sea is here presented. The skill of two ocean model solutions (derived ...from the Eulerian ocean forecast systems, such as the regional CMEMS IBI and the high resolution PdE SAMPA) in reproducing the complex surface dynamics in the above areas is evaluated. To this aim, in-situ measurements from the MEDESS-GIB drifter buoy database (comprising the Lagrangian positions, derived velocities and SST values) are used as the observational reference and the temporal coverage for the validation is 3 months (September to December 2014). Two metrics, a Lagrangian separation distance and a skill score, have been applied to evaluate the performance of the modelling systems in reproducing the observed trajectories. Furthermore, the SST validation with in-situ data is carried out by means of validating the model solutions with L3 satellite SST products. The Copernicus regional IBI products are evaluated in an extended domain, beyond the Alboran Sea, and covering western Mediterranean waters. This analysis reveals some strengths of the presented regional solution (i.e. realistic values of the Atlantic Jet in the Strait of Gibraltar area, realistic simulation of the Algerian Current). However, some shortcomings are also identified, with the major one being related to the simulated geographical position and intensity of the Alboran Gyres, particularly the western one. This performance limitation affects the IBI-modelled surface circulation in the entire Alboran Sea. On the other hand, the SAMPA system shows a more accurate model performance and it realistically reproduces the observed surface circulation in the area. The results reflect the effectiveness of the dynamical downscaling performed through the SAMPA system with respect to the regional IBI solution (in which SAMPA is nested), providing an objective measure of the potential added values introduced by the SAMPA downscaling solution in the Alboran Sea.
We present emission maps of the Sgr A molecular cloud complex at the Galactic center (GC) in the J = 2 -> 1 line of SiO observed with the IRAM 30 m telescope at Pico Veleta. Comparing our SiO(2-1) ...data cube with that of CS(1-0) emission with similar angular and velocity resolution, we find a correlation between the SiO/CS line intensity ratio and the equivalent width of the Fe Ka fluorescence line at 6.4 keV. We discuss the SiO abundance enhancement in terms of the two most plausible scenarios for the origin of the 6.4 keV Fe line: X-ray reflection nebula (XRN) and low-energy cosmic rays (LECRs). Both scenarios could explain the enhancement in the SiO/CS intensity ratio with the intensity of the 6.4 keV Fe line, but both present difficulties. The XRN scenario requires a population of very small grains to produce the SiO abundance enhancement, together with a past episode of bright X-ray emission from some source in the GC, possibly the central supermassive black hole, SgrA*, ~300 yr ago. The LECR scenario needs higher gas column densities to produce the observed 6.4 keV Fe line intensities than those derived from our observations. It is possible to explain the SiO abundance enhancement if the LECRs originate in supernovae and their associated shocks produce the SiO abundance enhancement. However, the LECR scenario cannot account for the time variability of the 6.4 keV Fe line, which can be naturally explained by the XRN scenario.
An explosive outbreak of Legionnaires' disease occurred in Murcia, Spain, in July 2001. More than 800 suspected cases were reported; 449 these cases were confirmed, which made this the world's ...largest outbreak of the disease reported to date. Dates of onset for confirmed cases ranged from June 26 to July 19, with a case-fatality rate of 1%. The epidemic curve and geographic pattern from the 600 competed epidemiologic questionnaires indicated an outdoor point-source exposure in the northern part of the city. A case-control study matching 85 patients living outside the city of Murcia with two controls each was undertaken to identify to outbreak source; the epidemiologic investigation implicated the cooling towers at a city hospital. An environmental isolate from these towers with an identical molecular pattern as the clinical isolates was subsequently identified and supported that epidemiologic conclusion.
We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, ...pharmacodynamic activity and identify the recommended dose.
Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using (99)Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.
Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1 ± 8.9 vs 31.3 ± 12.9 mg (P = 0.01). Both, AUC24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P < 0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P = 0.03) in tumour specimens.
Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.
The aim of the study was to develop a model of abdominal sepsis in the experimental animal.
Sprague-Dawley male rats of 5 weeks (N=39) were used. Initially, a pilot study (N = 9) was performed and ...distributed in 3 groups with 1cc inoculum of Escherichia coli ATCC 25922 intraperitoneally at concentrations of 10E8, 10E9 and 10E10 CFU. Subsequently, concentrations of 10E10 CFU are used in two groups of 3 rats with dilutions of 10 cc and 15 cc of distilled water respectively. Finally, a randomized trial of 24 rats was started in three treatment groups after intraperitoneal infection: Group I with physiological serum (N = 6), Group II with ceftriaxone (N = 9), Group III with ceftriaxone plus allicin (N = 9). Microbiological samples of blood and peritoneal fluid were made, as well as histopathological study of intraperitoneal organs (liver, diaphragm and peritoneum).
Death of 100% of the rats infected with 10E10 E. coli UFC concentration with the dilution of 15 ml of distilled water and without antibiotic was oberved. The blood culture and peritoneal fluid culture was positive for the same strain in all of them. The formation of abscesses on the liver surface and polymorphonuclear infiltration in tissues were observed.
The lethal dose of E. coli is 10E10 CFU diluted in 15 cc distilled water by intraperitoneal injection.
Patient access to orphan medicinal products (OMPs) is limited and varies between countries, reimbursement decisions on OMPs are complex, and there is a need for more transparent processes to know ...which criteria should be considered to inform these decisions. This study aimed to determine the most relevant criteria for the reimbursement of OMPs in Spain, from a multi-stakeholder perspective, and using multicriteria decision analysis (MCDA).
An MCDA was developed in 3 phases and included 28 stakeholders closely related to the field of rare diseases (6 physicians, 5 hospital pharmacists, 7 health economists, 4 patient representatives and 6 members from national and regional health authorities). Initially phase A, a bibliographic review was conducted to identify the potential reimbursement criteria. Then, a reduced advisory board (8 members) proposed, selected, and defined the final list of criteria that could be relevant for reimbursement. A discrete choice experiment (DCE) phase B was developed to determine the relevance and relative importance weight of such criteria according to the stakeholders' preferences by choosing between pairs of hypothetical financing scenarios. A multinomial logit model was fitted to analyze the DCE responses. Finally phase C, the advisory board review the results using a deliberative process.
Thirteen criteria were selected, related to 4 dimensions: patient population, disease, treatment, and economic evaluation. Nine criteria were deemed relevant for decision-making and associated with a higher relative importance: Health-related quality of life (HRQL) (23.53%), treatment efficacy (14.64%), availability of treatment alternatives (13.51%), disease severity (12.62%), avoided costs (11.21%), age of target population (7.75%), safety (seriousness of adverse events) (4.72%), quality of evidence (3.82%) and size of target population (3.12%). The remaining criteria had a < 3% relative importance: economic burden of disease (2.50%), cost of treatment (1.73%), cost-effectiveness (0.83%) and safety (frequency of adverse events) (0.03%).
The reimbursement of OMPs in Spain should be determined by its effect on patient's HRQL, the extent of its therapeutic benefit from efficacy and the availability of other therapeutic options. Furthermore, the severity of the rare disease should also influence the decision along with the potential of the treatment to avoid associated costs.
We present emission maps (spatial resolution ∼40 ) of the Sgr A molecular cloud complex at the Galactic Center (GC) in the J 2→1 SiO line, observed with the IRAM-30m telescope at Pico Veleta. We have ...compared our SiO(2-1) data cube with CS(1-0) maps, and we have found a correlation between the SiO/CS intensity ratio and the equivalent width of the X-ray Fe line at 6.4 keV. We discuss the SiO abundance enhancement in the two most plausible scenarios for the origin of the Fe line, which is, at the moment, under debate: fluorescence in an X-ray Reflection Nebula (XRN), or impact by Low-Energy Cosmic Rays (LECRs) followed by electronic relaxation. Both could explain the enhancement in the SiO/CS intensity ratio with the intensity of the Fe line, but both scenarios present difficulties: the first one requires a population of very small grains to produce the enhancement in the SiO/CS intensity ratio, and the second needs higher column densities than the ones derived from observations in the region.
Resumen Objetivo El objetivo de la I Conferencia Española de Consenso sobre el Injerto Óseo Sinusal era intentar llegar a puntos de acuerdo sobre las principales controversias de esta técnica, ...aplicada de forma muy variada y con el empleo de materiales muy diversos, y conseguir plasmar los mismos en un documento resumen consensuado por todos los autores. Material y método Durante los días 17 y 18 de octubre de 2008 se celebró en Oviedo la citada conferencia, auspiciada por la Sociedad Española de Cirugía Oral y Maxilofacial. En ella se dieron cita un total de 50 ponentes de reconocido prestigio nacional e internacional que repasaron en 6 mesas de trabajo las principales controversias sobre los injertos óseos sinusales. Tras las conferencias de los ponentes, los moderadores establecían las principales conclusiones de cada mesa y se abría un turno de debate donde participaban todos los asistentes. Resultado Este documento y sus conclusiones emanan de las presentaciones realizadas por los ponentes y de las deliberaciones y acuerdos de cada mesa de trabajo. Ambos han sido aprobados tras varias correcciones por todos los autores antes de ser enviados para su publicación. Además, han obtenido el reconocimiento científico oficial de la Sociedad Española de Cirugía Oral y Maxilofacial y deben servir como base para futuros estudios y reuniones científicas. Conclusiones El objetivo fundamental cuando se realiza un injerto óseo sinusal es la formación de hueso vital en el seno maxilar, para conseguir la supervivencia a largo plazo de los implantes tras su carga protésica. Para ello, la técnica y la secuencia de tratamiento deben orientarse a conseguir resultados predecibles y estables en el tiempo, aunque esto suponga un mayor tiempo de espera hasta la colocación de la prótesis. La estabilidad inicial del implante es el factor clave para la osteointegración y debe ser el principal criterio para indicar implantes simultáneos o diferidos en el seno maxilar.
PDF
