▶ Chronic cocaine exposure did not alter aSVZ BrdU labeling in mice. ▶ Chronic cocaine exposure increased SGZ BrdU labeling in mice in a spatio-temporal manner. ▶ BrdU labeling increases were ...restricted to the dorsal and not ventral SGZ and were noted after 1 and 3, but not 5 days of cocaine abstinence/post-BrdU labeling.
Cocaine abuse continues to be a significant problem in the USA and elsewhere. Cocaine is an indirect agonist for dopamine, norepinephrine and serotonin with numerous potential downstream effects, including processes and signals associated with adult neurogenesis. Since drug addiction is associated with brain plasticity, we hypothesized that cocaine exposure would alter cellular proliferation in two adult neurogenic regions (the subventricular and subgranular zones). We used bromodeoxyuridine (BrdU) to track newly generated cells in the brains of adult mice after chronic cocaine or saline exposures. No differences were found in the number or migration patterns of BrdU-labeled cells in the forebrain neurogenic areas. However, cocaine produced a significant increase in the number of hippocampal BrdU-labeled cells.
Using the CLEO II detector, we have obtained evidence for a new meson decaying to ital Dsup 0ital Ksup +. Its mass is 2573.2sub minus1.6sup +1.7plus minus0.8plus minus0.5 MeV/ital csup 2 and its ...width is 16sub minus4sup +5plus minus3 MeV/ital csup 2. Although we do not establish its spin and parity, the new meson is consistent with predictions for an ital L=1, ital S=1, ital Jsup ital P=2sup + charmed strange state.
A search for lepton flavor violating decays of the tau into either three charged leptons or one charged lepton and two charged hadrons was performed using 2.05 fbsup minus1 of data collected by the ...CLEO-II experiment at the Cornell Electron Storage Ring. The upper limits obtained for 22 decay branching fractions are several times more stringent than those set previously.
PDF
