CLIC is a proposal of CERN for a future high-energy particle collider. CLIC will collide electron and positron beams at a centre of mass energy of 3TeV with a desired peak luminosity of ...2×1034cm−2s−1. The luminosity performance of CLIC is sensitive to ground motion. Ground motion misaligns accelerator components, most importantly quadrupole magnets, which leads to emittance growth and beam–beam offset at the interaction point. This paper discusses the beam based feedback strategies currently used together with mechanical stabilization systems to address the above mentioned issues. These strategies consist of an Interaction Point Feedback (IPFB) and an Orbit Feedback (OFB). The two feedbacks have been designed independently and the main objective of this paper is to show how they interact. A simulation program is used in order to simulate the whole collider, it includes the behaviour of the beams, magnets, supports, ground attenuators, sensors, and actuators. Beam-offset feedback optimization and integrated simulations have been performed and results show that despite a detrimental coupling of both feedbacks at high frequency, it is possible to decrease the beam–beam offset and maintain the desired luminosity.
•A novel electromechanical structure is proposed for active ground motion isolation.•State of the art disturbance rejection at the subnanometer scale for heavy loads (up to 50kg) is achieved.•A 13dB ...attenuation of the ground motion is obtained between 12Hz and 100Hz.
Vibration isolation is a critical issue in various precision engineering fields. A new design of an active isolation system operating heavy loads (up to 50kg) is presented in this work. This system provides state of the art vibration isolation at the nanometer scale for magnets of a future particle accelerator and is more compact than other studies in this field. The choice of sensors and actuators, the mechanical design and the acquisition electronics are investigated in order to reject ground motion efficiently. A dynamic experimental characterization is performed. Based on the identified model, a specific controller, giving an attenuation between 10Hz and 100Hz was designed and experimentally qualified.
Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in ...normal endometrium and in ectopic endometriotic tissues.
Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method.
Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011).
The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.
This paper proposes a new approach for beam stabilization of the future Compact LInear Collider (CLIC). The method attempts to increase the efficiency of traditional methods. It is composed of a ...hybrid adaptive filtering algorithm that uses both feedback and adaptive control. The scheme uses an estimate of the prediction error to update the adaptive filter's parameters. The strategy of this method is described considering the process environment. The method efficiency is evaluated, and it is demonstrated that it provides high damping, fast vibration suppression, good robustness and easy realization thanks to the simplicity of the computations.
Written by the former chief foreign policy advisor to the Turkish president and based on unprecedented access to official documents and communiques, this book gives the inside story of Turkish US ...relations from the first Gulf War, through debates on the Iraqi Kurdish question, the 2003 invasion of Iraq and into the present day. Using events in Iraq as the basis for a theoretical case study, Gurcan Balik argues that Turkey influenced US foreign policy on several key occasions, and that Turkish support was instrumental in the first intervention in Iraq. After Iraq's 1991 uprisings, however, Turkey's interests in the Middle East began to diverge from those of the US, and their relationship gradually deteriorated, evident in Turkey's refusal to open up its northern border to aid the US advance to Baghdad in 2003. Balik contends that an 'Iraq gap' then emerged, which has since had major implications for the Turkish economy and for the future of the Middle East.Turkey and the US in the Middle East contains hitherto unpublished primary source material, and is an essential addition to the scholarship of the period.
Abstract
This retrospective study compared maternal and fetal outcomes after labour induction, using a dinoprostone vaginal pessary (Propess®) in midwife-led and obstetrician-led labour management. ...Labour induction outcomes, delivery mode and rates of admission to the neonatal intensive care unit were compared. A total of 405 women, 40.5% (n = 164) from midwife-led units and 59.5% (n = 241) from an obstetrician-led unit, participated. There was no statistically significant difference between the two groups in caesarean section rate or neonatal intensive care unit admission rates (p = 0.789 and 0.769, respectively). Non-reassuring fetal non-stress test and uterine hyperstimulation risks were higher in the obstetrician-led unit (p = 0.003 and 0.001, respectively, and odds ratio (OR) 0.165, 95% CI: 0.117-0.232 and OR 0.218, 95% CI: 0.078-0.611, respectively). Postpartum blood transfusion rate was higher in the midwife-led units (p = 0.002, OR 8.082, 95% CI: 1.879-39.292). Labour induction with Propess® is safe during both midwife-led and obstetrician-led labour management.
Here, we report a numerical experiment in which submicrometer particle entrainment in a periodic flow that matches those existing in the alveolus in the human lung was simulated for both sedentary ...and light activity. A spherical cavity with a prescribed velocity profile at the inlet was used to simulate the time-dependent periodical flow of air in the alveolus. Expansion and contraction of the alveolus were simulated by setting a conceptual permeable wall as the outer surface of the model and adjusting the boundary conditions in order to match the continuity of the flow. The simulations were conducted for breathing periods of 5 and 3 s, which match sedentary and light activity conditions, respectively, and the results were extrapolated to the real lung. It was found that, most of the particles mainly followed a straightforward path and reached the opposite side of the alveolar wall in both breathing conditions. The concentration patterns obtained are consistent with the fact that the flow within the alveolus is mainly diffusive and does not greatly depend on the flow velocity. It was found that the particles which are heavier than air move out of phase with the periodic airflow that crosses the alveolus entrance, and that these particles are significantly caught within the alveolus. Particle entrapment increases with breathing rate in accordance with experimental values and indicates that increase in breathing frequency in environments with high concentration of submicrometer particles has the consequence of increasing particle entrapment by several times with respect to normal breathing rate.
Objective: Emesis Gravidarum (EG) is common medical condition in pregnancy with significant negatively effects on daily social life, physical and psychological health. In this study, relationship of ...social support, psychological distress and mood disorders on EG were investigated. Methods: The pregnant women with mild EG were accepted as control group and moderate and severe EG were accepted as patient group. All patients completed sociodemographic data collection form, Pregnancy-Unique Quantification of Emesis and Nausea scale (PUQE-24), Symptom Check List questionnaire (SCL-90 R), Spielberger state-trait anxiety inventory (STAI), Beck depression inventory (BDI) and Multidimensional Scale of Perceived Social Support (MSPSS). STAI, BDI, MSPSS and GSI (global symptom index) scores of the patients and control groups were compared. Results: Statistically significant differences were found between the patients and control group on STAI score, BDI score and GSI scores. No statistically significant were found between the patients and control group on MSPSS score. Conclusion: Social support does not prevent patients from EG. But, there is a clear relationship between EG and psychological distress. Thus, psychiatric evaluation should be done in patients with EG. Obstetricians should encourage their patients to have psychiatric support. Further studies on relationship of psychosocial factors and EG are needed.
Sub-nanometer active seismic isolator control Balik, Gael; Caron, Bernard; Allibe, Julie ...
Journal of intelligent material systems and structures,
10/2013, Letnik:
24, Številka:
15
Journal Article
Recenzirano
Odprti dostop
Ambitious projects such as the design of the future Compact Linear Collider require challenging parameters and technologies. Stabilization of the Compact Linear Collider particle beam is one of these ...challenges. Ground motion is the main source of beam misalignment. Beam dynamics controls are, however, efficient only at low frequency (<4 Hz), due to the sampling of the beam at 50 Hz. Hence, ground motion mitigation techniques such as active stabilization are required. This article shows a dedicated prototype able to manage vibration at a sub-nanometer scale. The use of cutting edge sensor technology is, however, very challenging for control applications as they are usually used for measurement purposes. Limiting factors such as sensor dynamics and noise lead to a performance optimization problem. The current state of the art in ground motion measurement and ground motion mitigation techniques is pointed out and shows limits of the technologies. The proposed active device is then described, and a realistic model of the process has been established. A dedicated controller design combining feedforward and feedback techniques is presented, and theoretical results in terms of power spectral density of displacement are compared to real-time experimental results obtained with a rapid control prototyping tool.
PDF
