Abstract
Three bulk microphysics schemes with different complexities in the Weather Research and Forecasting Model are compared in terms of the individual microphysical process terms of the ...hydrometeor mass and number mixing ratio tendency equations in an idealized 2D squall-line case. Through evaluation of these process terms and of hydrometeor size distributions, it is shown that the differences in the simulated population characteristics of snow, graupel, and rainwater are the prominent factors contributing to the differences in the development of the simulated squall lines using these schemes. In this particular case, the gust front propagation speed produced by the Thompson scheme is faster than in the other two schemes during the first 2 h of the simulation because it has a larger dominant graupel size. After 2 h into the simulation, the initially less intense squall lines in the runs using the WSM6 and Morrison schemes start to catch up in intensity and development to the run using the Thompson scheme. Because the dominant size of graupel particles in the runs using the WSM6 and Morrison schemes is smaller, these particles take more time to fall below the freezing level and enhance the rainwater production and its evaporative cooling. In the run using the Thompson scheme, the graupel production slows down at later times while the snow particle growth increases, leading to more snow falling below the freezing level to melt and surpass graupel particle melting in the production of rainwater.
Objective To examine and quantify the potential dose-response relation between fruit and vegetable consumption and risk of all cause, cardiovascular, and cancer mortality.Data sources Medline, ...Embase, and the Cochrane library searched up to 30 August 2013 without language restrictions. Reference lists of retrieved articles.Study selection Prospective cohort studies that reported risk estimates for all cause, cardiovascular, and cancer mortality by levels of fruit and vegetable consumption.Data synthesis Random effects models were used to calculate pooled hazard ratios and 95% confidence intervals and to incorporate variation between studies. The linear and non-linear dose-response relations were evaluated with data from categories of fruit and vegetable consumption in each study.Results Sixteen prospective cohort studies were eligible in this meta-analysis. During follow-up periods ranging from 4.6 to 26 years there were 56 423 deaths (11 512 from cardiovascular disease and 16 817 from cancer) among 833 234 participants. Higher consumption of fruit and vegetables was significantly associated with a lower risk of all cause mortality. Pooled hazard ratios of all cause mortality were 0.95 (95% confidence interval 0.92 to 0.98) for an increment of one serving a day of fruit and vegetables (P=0.001), 0.94 (0.90 to 0.98) for fruit (P=0.002), and 0.95 (0.92 to 0.99) for vegetables (P=0.006). There was a threshold around five servings of fruit and vegetables a day, after which the risk of all cause mortality did not reduce further. A significant inverse association was observed for cardiovascular mortality (hazard ratio for each additional serving a day of fruit and vegetables 0.96, 95% confidence interval 0.92 to 0.99), while higher consumption of fruit and vegetables was not appreciably associated with risk of cancer mortality.Conclusions This meta-analysis provides further evidence that a higher consumption of fruit and vegetables is associated with a lower risk of all cause mortality, particularly cardiovascular mortality.
Whole grains are rich source of nutrients and have shown beneficial effects on human health. This study was designed to systematically review the existing results and quantitatively assess the ...dose-response relationship of whole grain intake with all-cause and cause-specific mortality.
We searched 'whole grain' or 'whole grains' in combination with 'mortality'' or 'cardiovascular disease' or 'cancer' through the Web of Science and PubMed databases till 20 January 2016. To be eligible for inclusion, publications should be prospective cohort studies and reported the influence of whole grain intake on human mortality. Relative risks (RRs) and 95% confidence intervals (CIs) from the included studies were pooled by a random effects model or fixed effect model.
We included 19 cohort studies from 17 articles, with 1 041 692 participants and 96 710 deaths in total, in the analyses. We observed an inverse relationship of whole grain intake with risk of total, cardiovascular disease and cancer mortality. The pooled RR was 0.84 (95% CI 0.81-0.88, n=9) for total mortality, 0.83 (95% CI 0.79-0.86, n=8) for CVD mortality and 0.94 (95% CI 0.87-1.01, n=14) for cancer mortality, comparing the highest intake of whole grain with the lowest category. For dose-response analysis, we found a nonlinear relationship of whole grain intake with risk of total, cardiovascular and cancer mortality. Each 28 g/d intake of whole grains was associated with a 9% (pooled RR: 0.91 (0.90-0.93)) lower risk for total mortality, 14% (pooled RR: 0.86 (0.83-0.89)) lower risk for CVD mortality and 3% (pooled RR: 0.97 (0.95-0.99)) lower risk for cancer mortality.
Our study shows that whole grain intake was inversely associated with risk of total, CVD and cancer mortality. Our results support current dietary guidelines to increase the intake of whole grains. Government officials, scientists and medical staff should take actions to promote whole grains intake.
BACKGROUND: Chronic inflammation and oxidative stress are common risk factors for atherosclerosis. Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, ...and as such, it may have atheroprotective properties. OBJECTIVE: We hypothesized that zinc down-regulates the production of atherosclerosis-related cytokines/molecules in humans. DESIGN: To examine these effects, we conducted a randomized, double-blinded, placebo trial of zinc supplementation in elderly subjects. We recruited 40 healthy elderly subjects (aged 56-83 y) and randomly assigned them to 2 groups. One group was given an oral dose of 45 mg zinc/d as a gluconate for 6 mo. The other group was given a placebo. Cell culture models were conducted to study the mechanism of zinc as an atheroprotective agent. RESULTS: After 6 mo of supplementation, the intake of zinc, compared with intake of placebo, increased the concentrations of plasma zinc and decreased the concentrations of plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, macrophage chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), secretory phospholipase A2, and malondialdehyde and hydroxyalkenals (MDA+HAE) in elderly subjects. Regression analysis showed that changes in concentrations of plasma zinc were inversely associated with changes in concentrations of plasma hsCRP, MCP-1, VCAM-1, and MDA+HAE after 6 mo of supplementation. In cell culture studies, we showed that zinc decreased the generation of tumor necrosis factor-α, IL-1β, VCAM-1, and MDA+HAE and the activation of nuclear transcription factor κB and increased antiinflammatory proteins A20 and peroxisome proliferator-activated receptor-α in human monocytic leukemia THP-1 cells and human aortic endothelial cells compared with zinc-deficient cells. CONCLUSION: These findings suggest that zinc may have a protective effect in atherosclerosis because of its antiinflammatory and antioxidant functions.
Abstract
This paper focuses on parameterizing the effect of sea spray at hurricane-strength winds on the momentum and heat fluxes in weather prediction models using the Monin–Obukhov similarity ...theory (a common framework for the parameterizations of air–sea fluxes). In this scheme, the mass-density effect of sea spray is considered as an additional modification to the stratification of the near-surface profiles of wind, temperature, and moisture in the marine surface boundary layer (MSBL). The overall impact of sea-spray droplets on the mean profiles of wind, temperature, and moisture depends on the wind speed at the level of sea-spray generation. As the wind speed increases, the mean droplet size and the mass flux of sea-spray increase, rendering an increase of stability in the MSBL and the leveling-off of the surface drag. Sea spray also tends to increase the total air–sea sensible and latent heat fluxes at high winds. Results from sensitivity testing of the scheme in a numerical weather prediction model for an idealized case of hurricane intensification are presented along with a dynamical interpretation of the impact of the parameterized sea-spray physics on the structure of the hurricane boundary layer.
► Tributyltin was not the most toxic antifouling biocides for 12 marine species. ► Irgarol was more toxic than TBT on the growth of autotrophic species. ► Toxicity of copper pyrithione was comparable ...to that of TBT for most test species. ► Copper pyrithione showed a higher toxicity than TBT on fish larvae. ► The toxicity data are useful for ecological risk assessment in tropics/subtropics.
Since 1990s, various booster biocides have been increasingly used as substitutes of organotins. However, knowledge about their toxicities on tropical/sub-tropical marine species is significantly lacking. This study comprehensively investigated the acute toxicities of copper, tributyltin (TBT), and five commonly used booster biocides including Irgarol, diuron, zinc pyrithione (ZnPT), copper pyrithione (CuPT) and chlorothalonil on the growth or survival of 12 marine species in which eight of them are native species of subtropical Hong Kong. We found that Irgarol was more toxic than TBT on the growth of autotrophic species. The toxicity of CuPT was comparable to that of TBT on almost all test species, while it showed higher toxicity than TBT on medaka fish larvae. As the usage of these biocides is expected to further increase worldwide, accurate assessments of their ecological risks are required for better informed decision on their management. This study provided useful datasets for such purposes.
Bilayer graphene is an attractive platform for studying new two-dimensional electron physics, because its flat energy bands are sensitive to out-of-plane electric fields and these bands magnify ...electron-electron interaction effects. Theory predicts a variety of interesting broken symmetry states when the electron density is at the carrier neutrality point, and some of these states are characterized by spontaneous mass gaps, which lead to insulating behaviour. These proposed gaps are analogous to the masses generated by broken symmetries in particle physics, and they give rise to large Berry phase effects accompanied by spontaneous quantum Hall effects. Although recent experiments have provided evidence for strong electronic correlations near the charge neutrality point, the presence of gaps remains controversial. Here, we report transport measurements in ultraclean double-gated bilayer graphene and use source-drain bias as a spectroscopic tool to resolve a gap of ∼2 meV at the charge neutrality point. The gap can be closed by a perpendicular electric field of strength ∼15 mV nm(-1), but it increases monotonically with magnetic field, with an apparent particle-hole asymmetry above the gap. These data represent the first spectroscopic mapping of the ground states in bilayer graphene in the presence of both electric and magnetic fields.
As an emergent electronic material and model system for condensed-matter physics, graphene and its electrical transport properties have become a subject of intense focus. By performing ...low-temperature transport spectroscopy on single-layer and bilayer graphene, we observe ballistic propagation and quantum interference of multiply reflected waves of charges from normal electrodes and multiple Andreev reflections from superconducting electrodes, thereby realizing quantum billiards in which scattering only occurs at the boundaries. In contrast to the conductivity of conventional two-dimensional materials, graphene's conductivity at the Dirac point is geometry-dependent because of conduction via evanescent modes, approaching the theoretical value 4e²/πh (where e is the electron charge and h is Planck's constant) only for short and wide devices. These distinctive transport properties have important implications for understanding chaotic quantum systems and implementing nanoelectronic devices, such as ballistic transistors.
An analytical relationship between the reduced modulus
E
r and hardness
H for solid materials is established based on the conventional depth-sensing indentation method of Oliver and Pharr. It is ...found that the two properties are related through a material parameter that is defined as the recovery resistance
R
s. This parameter is shown to represent the energy dissipation during indentation. Based on indentation measurements with the use of a Berkovich indenter, the relationship is given as
E
r
=
0.6647
HR
s
. Also presented is a simple set of procedures to determine the area of indent. The procedures require three measured quantities, i.e., the peak load and corresponding displacements as well as the depth of residual indentation, but do not require complicated curve fitting process and regression analysis which themselves involve the specimen material. Nano-indentation tests were conducted using a Berkovich indenter on five materials spanning a wide range of hardness and plasticity. Experimental results revealed two important features: (a) the reduced modulus predicted by the new
E
r–
H relationship is the same as that obtained by the conventional method; (b) the elastic modulus and hardness values determined by the simple set of procedures are comparable to those obtained by using the conventional method.
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