In this study, our purpose was to evaluate results of our experience with bone cement repair of ossicular discontinuity between the incus and stapes and between the malleus and stapes.
Medical ...records of patients who underwent surgery for chronic otitis media between March 2000 and December 2002 were evaluated retrospectively. Fifty-seven patients who underwent bone cement ossiculoplasty and had appropriate follow-up data were included in the study. Bone cement reconstruction of the ossicular chain was performed 1) from incus to stapes (I-S) in the absence of long arm or lenticular process of the incus and 2) from malleus to stapes (M-S) in the absence of the incus. The clinical data of the patients were evaluated by otoscopic examination and audiometry.
The graft take rate was 84.1%. I-S procedure was performed in 42 and M-S in 8 patients. Pre- and postoperative PTAs of all patients were compared, which showed a significant improvement in air PTA (p < 0.001) while bone PTA did not change (p > 0.05). In I-S and M-S groups, successful hearing restoration could be achieved in 78.6.1% and 87.5% of the patients, respectively. Hearing results of different aural pathologies (chronic otitis media and conductive hearing loss) and surgeries (tympanotomy and tympanoplasty with or without mastoidectomy) were not significantly different (p > 0.05).
Bone cement ossiculoplasty offers cost effective and significant improvement in conductive hearing loss.
Hodgkin's lymphoma (HL) comprises 20 to 30% of all lymphomas. Skin involvement is almost always secondary to visceral or nodal involvement. Secondary cutaneous HL is rare, occurring in only 0.5 to ...3.4% of the cases. Herein we report two cases of skin involvement in Hodgkin's disease. One was a 25‐year‐old female admitted with a draining sinus in the neck. The other was a 19‐year‐old female admitted with a neck mass and skin papules on her chest and arm. Skin involvement may antecede or can be seen during the course of HL. Better understanding of such cutaneous involvement, which occasionally may be the initial sign of HL, is needed, and a biopsy of any suspicious skin lesion should be considered.
To assess vestibular evoked myogenic potentials in patients with fibromyalgia syndrome.
Twenty-four patients with fibromyalgia syndrome (two men and 22 women) and 21 female controls were included in ...the study. All patients underwent vestibular evoked myogenic potential testing.
Statistical comparison of fibromyalgia patients with control subjects showed a significant difference with respect to n23 latencies and interpeak latencies (p < 0.05). There was no significant difference in p13 latencies, nor in p13 amplitudes, n23 amplitudes or interpeak amplitudes (p > 0.05).
Although patients with fibromyalgia syndrome generally have subjective neurotological symptoms, clinical and laboratory assessments usually fail to detect any objective abnormality. However, it is possible to detect abnormalities on vestibular evoked myogenic potential testing in such patients, indicating dysfunction in the vestibulospinal pathway, possibly in the saccule. Elongation of the n23 latency and of the interpeak latency of waves p13-n23, during vestibular evoked myogenic potential testing, may be a useful, objective indicator demonstrating neurotological involvement in fibromyalgia syndrome patients. Future research investigating the mechanisms of this latency elongation may help increase understanding of the pathogenesis of fibromyalgia syndrome.
Primary leiomyoma of the thyroid gland Erkiliç, Suna; Erkiliç, Ahmet; Bayazit, Yildirim A
Journal of laryngology and otology,
10/2003, Letnik:
117, Številka:
10
Journal Article
Recenzirano
Primary thyroid leiomyomas are rare, and only four cases have been reported to date. This is a report of an additional case of primary thyroid leiomyoma in a 40-year-old male who was admitted with a ...painless swelling in the right thyroid lobe and underwent subtotal thyroidectomy. The surgical specimen showed a well-circumscribed, greyish-white solid nodule. Histologically, the tumour was composed of spindle cells with blunt-ended nuclei that were arranged with short intersecting bundles. Immunohistochemical staining revealed reactivity with smooth muscle actin, vimentin and desmin. Histopathologic and immunohistochemical assessments produced the diagnosis of thyroid leiomyoma. Although primary thyroid leiomyoma is rare, it should be considered in the differential diagnosis of a cold thyroid nodule.
The objective of our study was to assess the association of eNOS4 and eNOS296 polymorphisms of endothelial nitric oxide synthase (eNOS) gene with obstructive sleep apnea syndrome (OSAS). Forty-eight ...patients with OSAS and 181 healthy volunteers were included in the study. Genotype analyses were performed for eNOS intron 4 VNTR and exon 7, Glu298Asp (G → T) polymorphisms. There was no significant difference between the patients and controls regarding eNOS4 polymorphism (
P
> 0.05). There was a significant difference between the patients and controls regarding eNOS296 polymorphism. Glu/Asp variant was more frequent whereas Glu/Glu variant was less frequent in the patients compared to controls (
P
< 0.001). There was no relationship between eNOS4 and eNOS296 polymorphisms and polysomnography parameters, apnea–hypopnea index, age, gender, body weight and height, body mass index, hypertension, coronary artery disease, arrhythmia, diabetes mellitus, hypercholesterolemia and smoking (
P
> 0.05). The eNOS4 polymorphism of NOS gene is not associated with OSAS. However, eNOS296 polymorphism of NOS gene is associated with occurrence of OSAS, but not with severity of OSAS.
The objective was to assess the significance of the catechol-o-methyltransferase (COMT) enzyme polymorphism in migraine. For this reason, 62 migraineurs and 64 healthy volunteers were included in the ...study. The analysis of COMT polymorphism was performed using PCR. The H/H genotype was more frequent in the control group than in the patients group (
P=0.032). The homozygous or heterozygous L allele was over represented in the migraineurs compared with the controls (
P=0.013). The L/L genotype was over represented in the migraineurs who also had a family history of migraine (
P=0.003). There was no relationship between aura and COMT genotypes. In conclusion, the COMT polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol drugs in migraineurs. Although altered catechoamine activity due to polymorphism of COMT gene may be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura.
Background and Objective: Obstructive sleep apnea syndrome (OSAS) is a common condition characterized by repetitive pharyngeal collapse during sleep and daytime sleepiness. There is genetic ...predisposition to sleep disorders. Serotonin is involved in the regulation of sleep. The synaptic 5‐hydroxytryptamine (HT) is inactivated by presynaptic reuptake, which is mediated by the serotonin transporter. Blockage of the serotonin transporter leads to increased extracellular 5‐HT. Polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level and may be important in OSAS. In this study, we aimed to assess the role of STG polymorphism in OSAS.
Methods: Twenty‐seven OSAS patients and 162 healthy volunteers were involved in the study. STG polymorphism was investigated using leukocytes obtained from peripheral blood.
Results: There was no difference between the genotypes and allele frequencies of the patients and controls regarding VNTR and HTTLPR polymorphisms (P > .05). The VNTR and HTTLPR variants and the frequencies of 12/12, 12/10, L, and S alleles were not significantly different between male and female control subjects (P > .05). The 12/12 and SS genotypes were over‐represented in the female patients, whereas 12/10 and LL genotypes were over‐represented in the male patients (P < .05). The genotypes 12 to 12 were over‐represented in the male controls, whereas the genotypes 12 to 10 and L/S were over‐represented in the male patients (P < .05). The alleles 10 and L were more frequent in the male patients than male controls (P < .05). The genotypes of female patients and female controls were not significantly different (P > .05). The allele 10 and L were less frequent in the female patients than female controls with Fisher's exact testing (P < .05). There was no relation between genotypes and clinical data of the patients (P > .05).
Conclusion: STG polymorphism appears to be associated with the occurrence of OSAS, especially in male patients. Absence of association of between genetic variants and polysomnography findings may suggest that some mechanisms other than STG polymorphism are involved in OSAS pathophysiology. Our results need confirmation in a larger group of patients with OSAS.
This study reports the authors' technique and hearing results with bone cement reconstruction of the incudostapedial chain. The technique is called incudostapedial rebridging ossiculoplasty.
A ...retrospective analysis of the hearing results of the incudostapedial rebridging ossiculoplasty was performed on 15 patients.
Recently, bone cements have been available commercially, and their use in otologic surgery is increasing. Polymaleinate glass ionomer cement is a commercially available bone cement that can be used to reconstruct a discontinuity between the incus and the stapes.
Tertiary referral center.
Disease-free or cleansed middle ear and mastoid and intact ossicular chain except for discontinuity between the long process of the incus and the head of the stapes.
Therapeutic.
Functional results of incudostapedial rebridging ossiculoplasty.
Of 15 patients, 9 achieved a successful hearing result (an air-bone gap within 20 dB) with incudostapedial rebridging ossiculoplasty after 1 year. The mean preoperative and postoperative air-bone gaps were 32.9 and 14.3 dB, respectively.
Incudostapedial rebridging ossiculoplasty with bone cement is a cost-effective and safe procedure that yields good hearing results in selected patients.
