Women with breast cancer (BCA) and cardiovascular disease (CVD) risk factors are at increased risk of developing cardiovascular complications when exposed to potentially cardiotoxic cancer therapy. ...The benefit of aggressive CVD risk factor modification to reduce adverse treatment-related psychologic and biologic effects is not well established.
Using a single group pre-test, post-test design, 33 women with BCA receiving anthracycline and/or trastuzumab therapy participated in a 6-month comprehensive CVD risk reduction program involving formal cardio-oncology evaluation along with regular motivational counseling for improved nutrition and physical activity. Study parameters were assessed at baseline and 6 months with paired t-tests used to evaluate changes after the intervention.
The mental component summary score assessed by SF-36
improved significantly after program completion (45.0 to 48.8, effect size 0.37, p = 0.017), however the physical component summary score declined (46.2 to 40.9, effect size - 0.53, p = 0.004). Despite this decline in perceived physical health, markers of health-related fitness and nutritional status were maintained or improved. Systolic and diastolic blood pressure also improved after the intervention (136.7 to 124.1 mmHg, p = 0.001 and 84.0 to 78.7 mmHg, p = 0.031, respectively). No significant change in resting heart rate, body mass index, lipids, hemoglobin A1C, or left ventricular ejection fraction was observed.
Patient-reported mental health improved significantly in women with BCA enrolled in a comprehensive CVD risk reduction program despite exposure to potentially cardiotoxic therapies. This study provides preliminary data for future randomized controlled trials evaluating the effects CVD risk reduction program in high-risk breast cancer cohorts.
The objective of this study was to examine the improvements in physiological outcomes, including exercise capacity, in women completing a 12-week gender-specific (tailored) compared with a ...traditional cardiac rehabilitation (CR) program.
A 2-group randomized clinical trial compared symptom limited graded exercise test (SL-GXT), lipid, and anthropometric parameters among 99 women completing a traditional 12-week CR program with 137 women completing a tailored CR program.
Compared with baseline, improvement in estimated peak metabolic equivalents (METs) was similar (P = .159) between the tailored (6.0 ± 2.7-7.6 ± 2.8) and the traditional CR programs (5.6 ± 2.3-7.1 ± 2.8). The amount of change in SL-GXT, anthropometric parameters, lipid profiles, and peak treadmill time from baseline to post-CR were also similar between the 2 groups. Given comparable improvements of the 2 CR programs, in the full cohort, factors independently associated with post-CR METs, in rank order, included baseline METs (part correlation = 0.44, P < .001), perceived physical functioning (0.24, P < .001), waist circumference (-0.10, P = .006), and age (-0.11, P = .004). Factors independently associated with post-CR treadmill time included baseline treadmill time (part correlation = 0.42, P < .001), perceived physical functioning (0.30, P < .001), waist circumference (-0.12, P = .002), and age (-0.10, P 5.006).
Exercise capacity was significantly improved among women completing both CR programs. In the context of CR, modifiable factors positively associated with post-CR exercise capacity included reduced waist circumference and improved physical functioning. Future research on strategies for reducing abdominal obesity and improving perceived physical functioning and exercise capacity among women attending CR is warranted.
Background/Purpose. The benefits of prescribing cardiac rehabilitation (CR) for patients following heart surgery is well documented; however, physicians continue to underuse CR programs, and ...disparities in the referral of women are common. Previous research into the causes of these problems has relied on self-report methods, which presume that physicians have insight into their referral behavior and can describe it accurately. In contrast, the research presented here used clinical judgment analysis (CJA) to discover the tacit judgment and referral policies of individual physicians. The specific aims were to determine 1) what these policies were, 2) the degree of self-insight that individual physicians had into their own policies, 3) the amount of agreement among physicians, and 4) the extent to which judgments were related to attitudes toward CR. Methods. Thirty-six Canadian physicians made judgments and decisions regarding 32 hypothetical cardiac patients, each described on 5 characteristics (gender, age, type of cardiovascular procedure, presence/absence of musculoskeletal pain, and degree of motivation) and then completed the 19 items of the Attitude towards Cardiac Rehabilitation Referral scale. Results. Consistent with previous studies, there was wide variation among physicians in their tacit and stated judgment policies, and self-insight was modest. On the whole, physicians showed evidence of systematic gender bias as they judged women as less likely than men to benefit from CR. Insight data suggest that 1 in 3 physicians were unaware of their own bias. There was greater agreement among physicians in how they described their judgments (stated policies) than in how they actually made them (tacit policies). Correlations between attitude statements and CJA measures were modest. Conclusions. These findings offer some explanation for the slow progress of efforts to improve CR referrals and for gender disparities in referral rates.
Background: Three million U.S. women live with heart failure (HF). Purpose: This study investigated relationships among self-care activation, social support, and self-care behaviors of women living ...with HF. Methods: A 52-item web-based survey was completed by 246 women living with HF. Results: Women reported a mean body mass index (BMI) of 30.8 ± 7.8 kg/m
2
, exercising a mean 106.5 ± 141.1 min/week, and consuming 3.25 ± 1.9 mean servings fruit/vegetables each day. Significant predictors of weekly physical activity minutes included self-care activation, activities of daily living (ADLs) total score, and current tobacco use. Low self-care activation, poor self-perceived health, greater ADL limitations, and more years living with HF were statistically significantly associated with having a higher BMI. Self-perceived health status and education and income levels were significant predictors of daily fruit/vegetable servings. Discussion: Although self-care activation was positively associated with health behaviors among women living with HF, self-care management of health behaviors remained suboptimal. Evaluating self-perceived health status of women with HF may identify appropriate interventions for improving self-care behaviors. Translation to Health Education Practice: Certified Health Education Specialists are encouraged to tailor their education to raising self-care activation, improving self-perceived health, underscoring the value of tangible physical activities (climbing stairs, walking, carrying groceries), and referring women with HF to cardiac rehabilitation.
Our aim was to compare the biopsychosocial characteristics of young women with those of older women who were enrolled in cardiac rehabilitation (CR). The baseline characteristics of women who ...prematurely terminated CR participation were also explored.
Baseline physiological and psychosocial indices of women ≤ 55 years compared with older women eligible for CR were evaluated 1 week before enrolling in either a traditional CR or a gender-specific, motivationally enhanced CR.
A greater proportion of young women (n = 65) compared with their older counterparts (n = 187) were diagnosed with acute myocardial infarction during their index hospitalization. They demonstrated lower high-density lipoprotein cholesterol, higher total cholesterol/high-density lipoprotein cholesterol ratios, and greater body weight compared with older women and were more likely to be active smokers. Young women compared with older women reported significantly worse health perceptions, quality of life, optimism, hope, social support, and stress and significantly more symptoms of depression and anxiety. Women who prematurely terminated CR participation were younger, more obese, with worse quality of life, and greater symptoms of depression and anxiety compared with women completing CR.
Notable differences in physiological and psychosocial profiles of young women compared with older women enrolled in CR were evident, placing them at high risk for nonadherence to secondary prevention interventions as well as increased risk for disease progression and subsequent cardiac adverse events. Continued existence of these health differentials represents an important public health problem and warrants further research to address these age-related and sex-specific health disparities among women with coronary heart disease.
The aim of this study was to compare the effects of a cardiac rehabilitation (CR) program tailored for women with a traditional program on perceptions of health among women with coronary heart ...disease.
This 2-group randomized clinical trial compared the perceptions of health among 92 women completing a traditional 12-week CR program with those of 133 women completing a tailored program that included motivational interviewing guided by the transtheoretical model of behavior change. Perceptions of health were measured using the SF-36 Health Survey at baseline, postintervention, and at 6-month follow-up. Analysis of variance was used to compare changes in SF-36 Health Survey subscale scores over time.
The group-by-time interaction was significant for the general health (F2,446 = 3.80, P = .023), social functioning (F2,446 = 4.85, P = .008), vitality (F2,446 = 5.85, P = .003), and mental health (F2,446 = 3.61, P = .028) subscales, indicating that the pattern of change was different between the 2 groups. Of the 4 subscales on which there were significant group-by-time interactions, the tailored group demonstrated improved scores over time on all 4 subscales, while the traditional group improved on only the emotional role limitations and vitality subscales.
A tailored CR program improved general health perceptions, mental health, vitality, and social functioning in women when compared with traditional CR. To the extent that perceptions of health contribute to healthy behaviors fostered in CR programs, tailoring CR programs to alter perceptions of health may improve adherence.
There is undeniable evidence for physical and psychosocial benefits of cardiac rehabilitation programs for individuals suffering from coronary heart disease. Yet, fewer women than men are referred ...to, begin, or complete cardiac rehabilitation programs. The numerous logistical, economic, and motivational barriers to healthy behavior change place women at risk for subsequent CHD events. To close this gender gap and improve outcomes, novel, efficacious, and individualized rehabilitative approaches for women with coronary heart disease are needed. The purpose of this article is to describe a theory-driven behavioral intervention designed exclusively for women with coronary heart disease. The 12-week intervention is being tested in a randomized controlled trial involving women referred to a cardiac rehabilitation program. The tenets of the Transtheoretical Model of behavior change and motivational interviewing guided the development and implementation of the stage-matched, individualized intervention to promote healthy behavior change for women with coronary heart disease. The ongoing trial will examine the efficacy of the intervention on physiological and psychosocial outcomes.
The 2021 ACC/AHA/SCAI coronary artery disease revascularization guideline highlights the importance of the multidisciplinary heart team in making patient-centered, evidence-based clinical decisions ...for patients considered for coronary revascularization. We present 2 cases highlighting aspects of heart team decision making for complex patients with coronary artery disease. (
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The executive summary of the American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions coronary artery revascularization guideline provides ...the top 10 items readers should know about the guideline. In the full guideline, the recommendations replace the 2011 coronary artery bypass graft surgery guideline and the 2011 and 2015 percutaneous coronary intervention guidelines. This summary offers a patient-centric approach to guide clinicians in the treatment of patients with significant coronary artery disease undergoing coronary revascularization, as well as the supporting documentation to encourage their use.
A comprehensive literature search was conducted from May 2019 to September 2019, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, CINHL Complete, and other relevant databases. Additional relevant studies, published through May 2021, were also considered.
Recommendations from the earlier percutaneous coronary intervention and coronary artery bypass graft surgery guidelines have been updated with new evidence to guide clinicians in caring for patients undergoing coronary revascularization. This summary includes recommendations, tables, and figures from the full guideline that relate to the top 10 take-home messages. The reader is referred to the full guideline for graphical flow charts, supportive text, and tables with additional details about the rationale for and implementation of each recommendation, and the evidence tables detailing the data considered in the development of this guideline.
The purpose of this article is to show, using principles from Shannon’s information theory, that it is possible to estimate the amount of information loss that occurs, in relative terms, when ...multiple continuous biological traits are dichotomized and aggregated, as is the case with many diagnostic definitions. We use metabolic syndrome as a case in point. It is our position that this type of information loss can impede the progress of medical research. This argument will first be made on theoretical grounds and then be supplemented using data from a clinical trial involving 252 women enrolled in cardiac rehabilitation. After laying out relevant principles, we conduct analyses to show how such information loss occurs during data transformation. Our analyses demonstrate that transforming the multiple traits that comprise metabolic syndrome into a single binary indicator discarded over 98% of the potential information contained in the original measurements. We go on to illustrate how such information loss impedes the establishment of meaningful statistical relationships with an indicator of cardiovascular health, time on an exercise tolerance test.
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