The reactor antineutrinos are used for the precise measurement of oscillation parameters in the 3-neutrino model, and also used to investigate active-sterile neutrino mixing sensitivity in the
3
+
1
...neutrino framework. In the present work, we study the feasibility of sterile neutrino search with the indian scintillator matrix for reactor anti-neutrino (ISMRAN) experimental set-up using electron antineutrinos (
ν
¯
e
) produced from reactor as a source. The so-called
3
+
1
scenario is considered for active-sterile neutrino mixing, which leads to projected exclusion curves in the sterile neutrino mass and mixing angle plane. The analysis is performed considering both the reactor and detector related parameters. It is found that, the ISMRAN set-up can observe the active-sterile neutrino mixing sensitivity for
sin
2
2
θ
14
≥
0.064
and
Δ
m
41
2
=
1.0
eV
2
at
90
%
confidence level for an exposure of 1 ton-year by using neutrinos produced from the DHRUVA reactor with thermal power of
100
MW
th
. It is also observed that, there is a significant improvement of the active-sterile neutrino mixing parameter
sin
2
2
θ
14
to
∼
0.03 at the same
Δ
m
41
2
by putting the ISMRAN detector set-up at a distance of 20 m from the compact proto-type fast breeder reactor facility with thermal power of 1250
MW
th
.
Ultrasmall MoS2 nanocrystals have unique optoelectronic and catalytic properties that have acquired significant attraction in many areas. We propose here a simple and economical method for ...synthesizing the luminescent nanocrystals MoS2 using the hydrothermal technique. In addition, the synthesized MoS2 nanocrystals display photoluminescence that is tunable according to size. MoS2 nanocrystals have many advantages, such as stable dispersion, low toxicity and luminescent characteristics, offering their encouraging applicability in biomedical disciplines. In this study, human lung cancer epithelial cells (A549) are used to assess fluorescence imaging of MoS2 nanocrystals. MTT assay, trypan blue assay, flow cytometry and fluorescence imaging results have shown that MoS2 nanocrystals can selectively target and destroy lung cancer cells, especially drug-resistant cells (A549).
Land use and land cover (LULC) change has been recognized as a key driver of global climate change by influencing land surface processes. Being in constant change, river basins are always subjected ...to LULC changes, especially decline in forest cover to give way for agricultural expansion, urbanization, industrialization etc. We used on-screen digital interpretation technique to derive LULC maps from Landsat images at three decadal intervals i.e., 1985, 1995 and 2005 of two major river basins of India. Rain-fed, Mahanadi river basin (MRB) attributed to 55% agricultural area wherein glacier-fed, Brahmaputra river basin (BRB) had only 16% area under agricultural land. Though conversion of forest land for agricultural activities was the major LULC changes in both the basins, the rate was higher for BRB than MRB. While water body increased in MRB could be primarily attributed to creation of reservoirs and aquaculture farms; snow and ice melting attributed to creation of more water bodies in BRB. Scrub land acted as an intermediate class for forest conversion to barren land in BRB, while direct conversion of scrub land to waste land and crop land was seen in MRB. While habitation contributed primarily to LULC changes in BRB, the proximity zones around habitat and other socio-economic drivers contributed to LULC change in MRB. Comparing the predicted result with actual LULC of 2005, we obtained >97% modelling accuracy; therefore it is expected that the Dyna-CLUE model has very well predicted the LULC for the year 2025. The predicted LULC of 2025 and corresponding LULC changes in these two basins acting as early warning, and with the past 2-decadal change analysis this study is believed to help the land use planners for improved regional planning to create balanced ecosystem, especially in a changing climate.
•Deforestation rate was nearly double fold in Brahmaputra than Mahanadi river basin•Satellite imagery based mapping offered LULC change with greater accuracy•Human disturbances is evident as major cause of LULC changes in the two river basins•Modelled LULC map of 2025 well predicted the past trends in both the river basins
In this article, crystal structure, magnetism, heat capacity, magnetocaloric effect (MCE), and electrical resistivity of mixed rare-earth Gd 0.5 Y 0.5 MnO 3 and Eu 0.5 Dy 0.5 MnO 3 manganites have ...been studied. Temperature-dependent magnetization M(T) measurements suggest an antiferromagnetic order just below 6 K in Gd 0.5 Y 0.5 MnO 3 , while no magnetic transition has been observed down to 5 K in Eu 0.5 Dy 0.5 MnO 3 . Heat capacity data reveal anomalies at 40 and 42 K in Gd 0.5 Y 0.5 MnO 3 and Eu 0.5 Dy 0.5 MnO 3 , and these may correspond to Mn magnetic order as previously reported. The magnetization values are 2.8 and 3 μ B /f.u. in 70 kOe field at 5 K for Gd 0.5 Y 0.5 MnO 3 and Eu 0.5 Dy 0.5 MnO 3 , respectively. MCE has been estimated in terms of isothermal magnetic entropy change (ΔS m ) at low temperatures. The maximum values of ΔS m are about -11 and -6.2 J kg -1 , respectively, for Gd 0.5 Y 0.5 MnO 3 and Eu 0.5 Dy 0.5 MnO 3 samples for a field change of 70 kOe at 8 K. Electrical resistivity of Gd 0.5 Y 0.5 MnO 3 and Eu 0.5 Dy 0.5 MnO 3 shows variable range polaron hopping behavior in the temperature range of 210-350 K.
The term "Telemedicine" is being used in the medical and health sector to treat patients and to provide medical guidance remotely. The intellectual output from India in terms of publications was ...harvested from Scopus
with the keyword "Telemedicine" and analyzed by using bibliometric techniques.
The source data was downloaded from the Scopus
database. All the publications on telemedicine and indexed in the database up to the year 2021 were considered for scientometric analysis. The software tools VOSviewer
version 1.6.18 to visualize bibliometric networks, statistical software R Studio
version 3.6.1 with the Bibliometrix package Biblioshiny
were used for analysis and data visualization, and EdrawMind
was used for mind mapping.
India contributed 2,391 (4.32%) publications on telemedicine to a total of 55,304 publications worldwide until 2021. There were 886 (37.05%) papers that appeared in open access mode. The analysis revealed that the first paper was published in the year 1995 from India. Steep growth in the number of publications was observed in 2020 with 458 publications. The highest, 54 research publications, appeared in the "Journal of Medical Systems." The All India Institute of Medical Sciences (AIIMS), New Delhi, contributed the highest number of publications (n = 134). A considerable overseas collaboration was observed (USA: 11%; UK: 5.85%).
This is the first such attempt to address the intellectual output of India in the emerging medical discipline of telemedicine and has yielded useful information such as leading authors, institutions, their impact, and year-wise topic trends.
In this work, we present an analysis of the sensitivity to the active-sterile neutrino mixing with the Indian Scintillator Matrix for Reactor Anti-Neutrino (ISMRAN) experimental setup at very short ...baseline. The 3 ( active ) + 1 (sterile) neutrino oscillation model is considered to study the sensitivity of the active-sterile neutrino in the mass splitting and mixing angle plane. In this article, we have considered the measurement of electron antineutrino induced events employing a single detector which can be placed either at a single position or moved between a near and far positions from the given reactor core. Results extracted in the later case are independent of the theoretical prediction of the reactor anti-neutrino spectrum and detector related systematic uncertainties. Our analysis shows that the results obtained from the measurement carried out at combination of the near and far detector positions are improved significantly at higher Δm412 compared to the ones obtained with the measurement at a single detector position only. It is found that the best possible combination of near and far detector positions from a 100 MWth power DHRUVA research reactor core are 7 m and 9 m, respectively, for which ISMRAN setup can exclude in the range 1.4 eV2 ≤ Δ m412 ≤ 4.0 eV2 of reactor antineutrino anomaly region along with the present best-fit point of active-sterile neutrino oscillation parameters. At those combinations of detector positions, the ISMRAN setup can observe the active sterile neutrino oscillation with a 95% confidence level provided that sin22θ14 ≥ 0.09 at Δm412 = 1 eV2 for an exposure of 1 ton-yr. The active-sterile neutrino mixing sensitivity can be improved by about 22% at the same exposure by placing the detector at near and far distances of 15 m and 17 m, respectively, from the compact proto-type fast breeder reactor (PFBR) facility which has a higher thermal power of 1250 MWth.
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Plant lectins are non-immunoglobin in nature and bind to the carbohydrate moiety of the glycoconjugates without altering any of the recognized glycosyl ligands. Plant lectins have ...found applications as cancer biomarkers for recognizing the malignant tumor cells for the diagnosis and prognosis of cancer. Interestingly, plant lectins contribute to inducing cell death through autophagy and apoptosis, indicating their potential implication in cancer inhibitory mechanism. In the present review, anticancer activities of major plant lectins have been documented, with a detailed focus on the signaling circuit for the possible molecular targeted cancer therapy. In this context, several lectins have exhibited preclinical and clinical significance, driving toward therapeutic potential in cancer treatment. Moreover, several plant lectins induce immunomodulatory activities, and therefore, novel strategies have been established from preclinical and clinical investigations for the development of combinatorial treatment consisting of immunotherapy along with other anticancer therapies. Although the application of plant lectins in cancer is still in very preliminary stage, advanced high-throughput technology could pave the way for the development of lectin-based complimentary medicine for cancer treatment.
The proposed India-based Neutrino Observatory will host a 50 kton magnetized iron calorimeter (ICAL) with resistive plate chambers as its active detector element. Its primary focus is to study ...charged-current interactions of atmospheric muon neutrinos via the reconstruction of muons in the detector. We present the first study of the energy and direction reconstruction of the final state lepton and hadrons produced in charged current interactions of atmospheric electron neutrinos at ICAL and the sensitivity of these events to neutrino oscillation parameters θ23 and Δm232. However, the signatures of these events are similar to those from neutral-current interactions and charged-current muon neutrino events in which the muon track is not reconstructed. On including the entire set of events that do not produce a muon track, we find that reasonably good sensitivity to θ23 is obtained, with a relative 1σ precision of 15% on the mixing parameter sin2θ23, which decreases to 21%, when systematic uncertainties are considered.
In the era of rapid climate change, abiotic stresses are the primary cause for yield gap in major agricultural crops. Among them, salinity is considered a calamitous stress due to its global ...distribution and consequences. Salinity affects plant processes and growth by imposing osmotic stress and destroys ionic and redox signaling. It also affects phytohormone homeostasis, which leads to oxidative stress and eventually imbalances metabolic activity. In this situation, signaling compound crosstalk such as gasotransmitters nitric oxide (NO), hydrogen sulfide (H
2
S), hydrogen peroxide (H
2
O
2
), calcium (Ca), reactive oxygen species (ROS) and plant growth regulators (auxin, ethylene, abscisic acid, and salicylic acid) have a decisive role in regulating plant stress signaling and administer unfavorable circumstances including salinity stress. Moreover, recent significant progress in omics techniques (transcriptomics, genomics, proteomics, and metabolomics) have helped to reinforce the deep understanding of molecular insight in multiple stress tolerance. Currently, there is very little information on gasotransmitters and plant growth regulator crosstalk and inadequacy of information regarding the integration of multi-omics technology during salinity stress. Therefore, there is an urgent need to understand the crucial cell signaling crosstalk mechanisms and integrative multi-omics techniques to provide a more direct approach for salinity stress tolerance. To address the above-mentioned words, this review covers the common mechanisms of signaling compounds and role of different signaling crosstalk under salinity stress tolerance. Thereafter, we mention the integration of different omics technology and compile recent information with respect to salinity stress tolerance.
Dysregulation of the epigenome and constitutional epimutation lead to aberrant expression of the genes, which regulate cancer initiation and progression. Histone deacetylases (HDACs), which are ...highly conserved in yeast to humans, are known to regulate numerous proteins involved in the transcriptional regulation of chromatin structures, apoptosis, autophagy, and mitophagy. In addition, a non-permissive chromatin conformation is created by HDACs, preventing the transcription of the genes encoding the proteins associated with tumorigenesis. Recently, an expanding perspective has been reported from the clinical trials with HDACis (HDAC inhibitors), which has emerged as a determining target for the study of the detailed mechanisms underlying cancer progression. Therefore, the present review focuses on the comprehensive lucubration of post-translational modifications and the molecular mechanisms through which HDACs alter the ambiguities associated with epigenome, with particular insights into the initiation, progression, and regulation of cancer.
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