Neuroscientists have debated for centuries whether some regions of the human brain are selectively engaged in specific high-level mental functions or whether, instead, cognition is implemented in ...multifunctional brain regions. For the critical case of language, conflicting answers arise from the neuropsychological literature, which features striking dissociations between deficits in linguistic and nonlinguistic abilities, vs. the neuroimaging literature, which has argued for overlap between activations for linguistic and nonlinguistic processes, including arithmetic, domain general abilities like cognitive control, and music. Here, we use functional MRI to define classic language regions functionally in each subject individually and then examine the response of these regions to the nonlinguistic functions most commonly argued to engage these regions: arithmetic, working memory, cognitive control, and music. We find little or no response in language regions to these nonlinguistic functions. These data support a clear distinction between language and other cognitive processes, resolving the prior conflict between the neuropsychological and neuroimaging literatures.
State-space multitaper time-frequency analysis Kim, Seong-Eun; Behr, Michael K.; Ba, Demba ...
Proceedings of the National Academy of Sciences - PNAS,
01/2018, Letnik:
115, Številka:
1
Journal Article
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Time series are an important data class that includes recordings ranging from radio emissions, seismic activity, global positioning data, and stock prices to EEG measurements, vital signs, and voice ...recordings. Rapid growth in sensor and recording technologies is increasing the production of time series data and the importance of rapid, accurate analyses. Time series data are commonly analyzed using time-varying spectral methods to characterize their nonstationary and often oscillatory structure. Current methods provide local estimates of data features. However, they do not offer a statistical inference framework that applies to the entire time series. The important advances that we report are state-space multitaper (SS-MT) methods, which provide a statistical inference framework for time-varying spectral analysis of nonstationary time series. We model nonstationary time series as a sequence of second-order stationary Gaussian processes defined on nonoverlapping intervals. We use a frequency-domain random-walk model to relate the spectral representations of the Gaussian processes across intervals. The SS-MT algorithm efficiently computes spectral updates using parallel 1D complex Kalman filters. An expectation–maximization algorithm computes static and dynamic model parameter estimates. We test the framework in time-varying spectral analyses of simulated time series and EEG recordings from patients receiving general anesthesia. Relative to standard multitaper (MT), SS-MT gave enhanced spectral resolution and noise reduction (>10 dB) and allowed statistical comparisons of spectral properties among arbitrary time series segments. SS-MT also extracts time-domain estimates of signal components. The SS-MT paradigm is a broadly applicable, empirical Bayes’ framework for statistical inference that can help ensure accurate, reproducible findings from nonstationary time series analyses.
Since mid-2015, there has been an increasing number of chicken samples that are positive for infectious bronchitis virus (IBV) in a screening PCR but which do not show positive results in any ...established, variant-specific PCR tests (793B, QX, D1466, Massachusetts, D274, Italy 02, Arkansas, Variant 2, Q1). Partial sequencing of the viral genome of those samples shows great similarities, but nucleotide similarity in the S1 gene is only about 57%-61% when compared to any other known GI-GVII IBV genotype and lineage. With nucleotide identity in the S1 gene of approximately 80%, the closest related strain in the National Center for Biotechnology Information database (as of March 15, 2020) is the North American PA/1220/98 isolate (AY789942) designated as a unique variant by Valastro
. in 2016. Due to its divergence from other IBV strains, we propose that strain, designated IB80, is the type strain of a novel IBV genotype GVIII. So far, IB80 has been detected in commercial layer and broiler parent flocks, frequently showing severe drops in egg production as well as in broiler flocks in Europe and beyond.
As society has moved past the initial phase of the COVID-19 crisis that relied on broad-spectrum shutdowns as a stopgap method, industries and institutions have faced the daunting question of how to ...return to a stabilized state of activities and more fully reopen the economy. A core problem is how to return people to their workplaces and educational institutions in a manner that is safe, ethical, grounded in science, and takes into account the unique factors and needs of each organization and community. In this paper, we introduce an epidemiological model (the "Community-Workplace" model) that accounts for SARS-CoV-2 transmission within the workplace, within the surrounding community, and between them. We use this multi-group deterministic compartmental model to consider various testing strategies that, together with symptom screening, exposure tracking, and nonpharmaceutical interventions (NPI) such as mask wearing and physical distancing, aim to reduce disease spread in the workplace. Our framework is designed to be adaptable to a variety of specific workplace environments to support planning efforts as reopenings continue. Using this model, we consider a number of case studies, including an office workplace, a factory floor, and a university campus. Analysis of these cases illustrates that continuous testing can help a workplace avoid an outbreak by reducing undetected infectiousness even in high-contact environments. We find that a university setting, where individuals spend more time on campus and have a higher contact load, requires more testing to remain safe, compared to a factory or office setting. Under the modeling assumptions, we find that maintaining a prevalence below 3% can be achieved in an office setting by testing its workforce every two weeks, whereas achieving this same goal for a university could require as much as fourfold more testing (i.e., testing the entire campus population twice a week). Our model also simulates the dynamics of reduced spread that result from the introduction of mitigation measures when test results reveal the early stages of a workplace outbreak. We use this to show that a vigilant university that has the ability to quickly react to outbreaks can be justified in implementing testing at the same rate as a lower-risk office workplace. Finally, we quantify the devastating impact that an outbreak in a small-town college could have on the surrounding community, which supports the notion that communities can be better protected by supporting their local places of business in preventing onsite spread of disease.
The physics program at the super-conducting fragment separator (Super-FRS) at FAIR, being operated in a multiple-stage, high-resolution spectrometer mode, is discussed. The Super-FRS will produce, ...separate and transport radioactive beams at high energies up to 1.5 AGeV, and it can be also used as a stand-alone experimental device together with ancillary detectors. Various combinations of the magnetic sections of the Super-FRS can be operated in dispersive, achromatic or dispersion-matched spectrometer ion-optical modes, which allow measurements of momentum distributions of secondary-reaction products with high resolution and precision. A number of unique experiments in atomic, nuclear and hadron physics are suggested with the Super-FRS as a stand-alone device, in particular searches for new isotopes, studies of hypernuclei, delta-resonances in exotic nuclei and spectroscopy of atoms characterized by bound mesons. Rare decay modes like multiple-proton or neutron emission and the nuclear tensor force observed in high-momentum regime can be also addressed. The in-flight radioactivity measurements as well as fusion, transfer and deep-inelastic reaction mechanisms with the slowed-down and energy-bunched fragment beams are proposed for the high-resolution and energy buncher modes at the Super-FRS.
Abstract
Interests on few-body hypernuclei have been increased by recent results of experiments employing relativistic heavy ion beams. Some of the experiments have revealed that the lifetime of the ...lightest hypernucleus, hypertriton, is significantly shorter than 263 ps which is expected by considering the hypertriton to be a weakly-bound system. The STAR collaboration has also measured the hypertriton binding energy, and the deduced value is contradicting to its formerly known small binding energy. These measurements have indicated that the fundamental physics quantities of the hypertriton such as its lifetime and binding energy have not been understood, therefore, they have to be measured very precisely. Furthermore, an unprecedented Λnn bound state observed by the HypHI collaboration has to be studied in order to draw a conclusion whether or not such a bound state exists. These three-body hypernuclear states are studied by the heavy-ion beam data in the WASA-FRS experiment and by analysing J-PARC E07 nuclear emulsion data with machine learning.
We have developed a compact detector for measuring beam particles using plastic scintillators readout through Multi-Pixel Photon Counters, which is employed for hypernuclear measurements in the ...WASA-FRS experiment at GSI. The Time-of-Flight resolution of the newly-developed detector has been investigated in relation to the overvoltage with respect to the breakdown voltage, a maximum counting rate of approximately 3×106/s per segment, and a maximum beam charge of Z = 6. The evaluated Time-of-Flight resolutions between the neighboring segments of the detector range from 44.6±1.3 ps to 100.3±3.6 ps (σ) depending on the segment, overvoltage values, and beam intensity. It is also observed that the Time-of-Flight resolution is inversely correlated to the beam atomic charge (Z).
The status of the Super-FRS in-flight facility at FAIR Winkler, M.; Geissel, H.; Weick, H. ...
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms,
October 2008, 2008-10-00, Letnik:
266, Številka:
19-20
Journal Article
Recenzirano
The future international facility FAIR (Facility for Antiprotons and Ion Research) will deliver beams of all ions up to uranium with intensities of up to 1012 ions/s. At FAIR it will be possible to ...perform experiments in different fields of physics. A wide range of ions with energies up to 1.5AGeV will be used for the production of fragments by projectile fragmentation/fission at the in-flight fragment separator, Super-FRS. Rare isotopes of all elements up to uranium will be produced and spatially separated within a few hundred nanoseconds, enabling the study of very short-lived nuclei.
The Super-FRS is a large-acceptance device utilizing large-aperture superconducting magnets and employing multiple degrader stages to provide monoisotopic nuclear beams. It serves different experimental branches including a new storage-cooler ring system. Because of high primary beam intensity a challenging design of the target area and the components used in the first dipole stage of the Super-FRS is necessary. These efforts include high-power production targets, beam dumps to catch the remaining primary beam and radiation resistant magnets. In this contribution we present the status of the project.
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