Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular ...disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.
There are few studies analyzing the surgical site infection (SSI) rate of second intention wounds after dermatologic surgery, and the results are inconclusive. Yet, the current dogma in dermatologic ...surgery is that wounds healed by second intention have lower infection rates.
To determine the rate of SSI and associated pathogenic organisms of second intention wounds compared with sutured wounds after skin cancer extirpation.
This was a retrospective cohort study of patients who had either Mohs micrographic surgery or wide local excision (WLE) for skin cancer extirpation between 2012 and 2016. Wounds were stratified by closure type, location, and associated organisms. Infection was diagnosed by a positive wound culture.
The overall infection rate was 3.9%. The infection rate for sutured and second intention wounds was 3.2% and 6.8%, respectively. Second intention wounds were associated with a significantly higher risk of infection compared with sutured wounds (odds ratio = 2.22, 95% confidence interval 1.63-2.99). The lower extremity (LE) had the highest overall infection rate (10.5%). The face had the lowest overall infection rate (2.5%).
Mohs micrographic surgery or WLE performed on the LE or lesions allowed to heal by second intention has an increased risk of SSI.
Primary vulvar melanoma in an adolescent patient Li, Kathy P.; Ajebo, Etsubdenk M.; Diamond, Davis ...
Pediatric dermatology,
July/August 2023, 2023 Jul-Aug, 2023-07-00, 20230701, Letnik:
40, Številka:
4
Journal Article
Recenzirano
Herein we describe the case of a Black adolescent who was found to have widely metastatic melanoma originating from a primary vulvar lesion. The lesion presented as a pink, vegetative nodule of the ...clitoral hood which grew in size over several years and was confirmed to be melanoma on shave biopsy. This patient's amelanotic presentation in conjunction with the rare incidence of vulvar melanoma contributed to the delay in diagnosis. This case exemplifies the challenge of early recognition of potentially malignant vulvar lesions for primary care providers in adolescents.
The treatment of nonmelanoma skin cancer (NMSC) in the elderly population is a source of significant debate. Mohs micrographic surgery (MMS) is a highly effective treatment option yet not every ...patient with a cutaneous malignancy that meets appropriate use criteria (AUC) should be treated with surgery.
The purpose of this study was to use the Karnofsky Performance Status (KPS) scale to categorize the functional status of patients aged 75 years and older who required treatment of NMSC. The authors wanted to see whether functionality played a role on the treatment selection.
Patients aged 75 years and older presenting for biopsy of a suspected NMSC that met AUC for MMS were included in the study. Trained medical assistants used the KPS scale to assess patient functionality. Treatment modality was recorded once the biopsy confirmed the NMSC.
A cohort of 203 subjects met inclusion criteria for the study. There was a statistically significant difference in utilization of surgical treatments between high and low functionality patients (p = .03).
Dermatologists consider patient functionality when selecting a treatment for NMSC and use less invasive modalities for patients with poor functional status, even when the tumor meets AUC.
With a dominant concentration on the cultural politics in the GDR, Germanists have neglected topics in landscape, environment and nature, despite East German authors' central role in advancing the ...ecological discourse. This project unearths and explores historically recognizable backgrounds and progressive ambitions in East German environmental literature to reveal ecology as a manifold literary subject embodying a spectrum of anthropocentric and natural foci, within yet above the socialist political framework of the GDR. Through archival documents from the East German Ministry for State Security (or Stasi)—which introduces a new reception methodology to literary scholarship—and detailed literary analysis of works by the East German authors Erwin Strittmatter, Johannes Bobrowski, Hanns Cibulka, Monika Maron and Christa Wolf, this study traces a narrative of regional and global environmental consciousness beginning in the nineteenth century with Theodor Fontane and leading up to German reunification, thereby challenging normative perceptions of East German literature as insular. The project investigates East German literature's relationship to its contemporary environmental context and answers the following critical questions: How did ecological consciousness inform the works of key GDR writers; what forms did their expressions take; how do these forms fit within the broader scope of (East) German literary history, and conversely, how did their literary works influence the development of the real-world East German environmental movement? To contextualize these issues historically, the project also examines the political history of environmentalism in the GDR, particularly the official Umweltpolitik and the oppositional organizations influencing environmental policies. German environmentalism's progression from the nineteenth-century conservative Heimatschutzbewegung to a contemporary progressive movement is intriguing, for ironically, the common use of conservative literary motifs of landscape and regional Heimat mark the path toward progressivism.
The purpose of Section 751(b), referred to as the collapsible partnership provision, was to prevent: 1. the conversion of the character of ordinary income into capital gain, and 2. the shifting of ...ordinary income among partners. Section 751(b) provides one exemption to the general nonrecognition rule of Section 731 if a distributee partner receives more or less than its proportionate share of the distributing partnership's so-called hot assets. For purposes of Section 751(b), hot assets include both unrealized receivables and substantially appreciated inventory. The IRS' goal of revisiting the regulations under Section 751(b) should be applauded and taxpayers will welcome a less complicated alternative to the current regime. In issuing Notice 2006-14, the IRS has shown that it is wiling to revisit the approach taken to ease taxpayer compliance while satisfying the purpose of Section 751(b). The proposed cures have their fair share of complications. For example, both the hypothetical sale approach and the hot asset sale approach create unexpected and unintended results in specific instances.
Proposed Regulations implemented on August 22, 2007 address property distributions following assets-over partnership mergers. The objective of the IRS and Treasury in issuing the Proposed Regulations ...is to provide consistency under the anti-mixing bowl rules with regard to the different layers of Section 704(c) gain or loss that can exist or be created as a result of an assets-over-partnership merger. It is clear, as is often the case with rulemaking, that the IRS and Treasury have made certain policy decisions based upon administrative feasibility. Although questions remain it is believed that they have presented the foundation for a well-constructed and administrable framework.
PDF
