Gaseous and stellar metallicities in galaxies are nowadays routinely used to constrain the evolutionary processes in galaxies. This requires the knowledge of the average yield per stellar generation, ...y..., i.e. the quantity of metals that a stellar population releases into the interstellar medium (ISM), which is generally assumed to be a fixed fiducial value. Deviations of the observed metallicity from the expected value of y... are used to quantify the effect of outflows or inflows of gas, or even as evidence for biased metallicity calibrations or inaccurate metallicity diagnostics. Here, we show that y... depends significantly on the initial mass function (IMF), varying by up to a factor larger than three, for the range of IMFs typically adopted in various studies. Varying the upper mass cutoff of the IMF implies a further variation of y... by an additional factor that can be larger than two. These effects, along with the variation of the gas mass fraction restored into the ISM by supernovae (R, which also depends on the IMF), may yield to deceiving results, if not properly taken into account. In particular, metallicities that are often considered unusually high can actually be explained in terms of yield associated with commonly adopted IMFs such as the Kroupa or Chabrier. We provide our results for two different sets of stellar yields (both affected by specific limitations) finding that the uncertainty introduced by this assumption can be as large as ~0.2 dex. Finally, we show that y... is not substantially affected by the initial stellar metallicity as long as Z > 10... Z... (ProQuest: ... denotes formulae/symbols omitted.)
Abstract
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms, IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and appear to ...be determined by their different binding affinities for insulin-like growth factors (IGFs), particularly for IGF-2. Predominant roles of IR-A in prenatal growth and development and of IR-B in metabolic regulation are well established. However, emerging evidence indicates that the differential expression of IR isoforms may also help explain the diversification of insulin and IGF signaling and actions in various organs and tissues by involving not only different ligand-binding affinities but also different membrane partitioning and trafficking and possibly different abilities to interact with a variety of molecular partners. Of note, dysregulation of the IR-A/IR-B ratio is associated with insulin resistance, aging, and increased proliferative activity of normal and neoplastic tissues and appears to sustain detrimental effects. This review discusses novel information that has generated remarkable progress in our understanding of the physiology of IR isoforms and their role in disease. We also focus on novel IR ligands and modulators that should now be considered as an important strategy for better and safer treatment of diabetes and cancer and possibly other IR-related diseases.
We discuss recent work on the physiology of IR isoforms and their role in disease including new findings on IR ligands and modulators that are relevant to the treatment of diabetes and other disorders.
The development of therapeutic resistance to targeted anticancer therapies remains a significant clinical problem, with intratumoral heterogeneity playing a key role. In this context, improving the ...therapeutic outcome through simultaneous targeting of multiple tumor cell subtypes within a heterogeneous tumor is a promising approach. Liposomes have emerged as useful drug carriers that can reduce systemic toxicity and increase drug delivery to the tumor site. While clinically used liposomal drug formulations show marked therapeutic advantages over free drug formulations, ligand-functionalized liposomes that can target multiple tumor cell subtypes may further improve the therapeutic efficacy by facilitating drug delivery to a broader population of tumor cells making up the heterogeneous tumor tissue. Ligand-directed liposomes enable the so-called active targeting of cell receptors via surface-attached ligands that direct drug uptake into tumor cells or tumor-associated stromal cells, and so can increase the selectivity of drug delivery. Despite promising preclinical results demonstrating improved targeting and anti-tumor effects of ligand-directed liposomes, there has been limited translation of this approach to the clinic. Key challenges for translation include the lack of established methods to scale up production and comprehensively characterize ligand-functionalized liposome formulations, as well as the inadequate recapitulation of in vivo tumors in the preclinical models currently used to evaluate their performance. Herein, we discuss the utility of recent ligand-directed liposome approaches, with a focus on dual-ligand liposomes, for the treatment of solid tumors and examine the drawbacks limiting their progression to clinical adoption.
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In this paper, we propose a new polar code construction by employing kernels of different sizes in the Kronecker product of the transformation matrix, thus generalizing the original construction by ...Arikan. These multi-kernel polar codes allow for more flexibility in terms of the code length and for various new design principles. Next to the common reliability design, we provide a design to maximize the minimal distance and a hybrid design combining reliability and distance properties. Numerical results demonstrate the advantage of multi-kernel polar codes under the new design principles compared to punctured and shortened Arikan polar codes.
Aims.
The complexity of star formation at the physical scale of molecular clouds is not yet fully understood. We investigate the mechanisms regulating the formation of stars in different environments ...within nearby star-forming galaxies from the Physics at High Angular resolution in Nearby GalaxieS (PHANGS) sample.
Methods.
Integral field spectroscopic data and radio-interferometric observations of 18 galaxies were combined to explore the existence of the resolved star formation main sequence (Σ
stellar
versus Σ
SFR
), resolved Kennicutt–Schmidt relation (Σ
mol. gas
versus Σ
SFR
), and resolved molecular gas main sequence (Σ
stellar
versus Σ
mol. gas
), and we derived their slope and scatter at spatial resolutions from 100 pc to 1 kpc (under various assumptions).
Results.
All three relations were recovered at the highest spatial resolution (100 pc). Furthermore, significant variations in these scaling relations were observed across different galactic environments. The exclusion of non-detections has a systematic impact on the inferred slope as a function of the spatial scale. Finally, the scatter of the Σ
mol. gas + stellar
versus Σ
SFR
correlation is smaller than that of the resolved star formation main sequence, but higher than that found for the resolved Kennicutt–Schmidt relation.
Conclusions.
The resolved molecular gas main sequence has the tightest relation at a spatial scale of 100 pc (scatter of 0.34 dex), followed by the resolved Kennicutt–Schmidt relation (0.41 dex) and then the resolved star formation main sequence (0.51 dex). This is consistent with expectations from the timescales involved in the evolutionary cycle of molecular clouds. Surprisingly, the resolved Kennicutt–Schmidt relation shows the least variation across galaxies and environments, suggesting a tight link between molecular gas and subsequent star formation. The scatter of the three relations decreases at lower spatial resolutions, with the resolved Kennicutt–Schmidt relation being the tightest (0.27 dex) at a spatial scale of 1 kpc. Variation in the slope of the resolved star formation main sequence among galaxies is partially due to different detection fractions of Σ
SFR
with respect to Σ
stellar
.
Abstract
We study the gas phase metallicity (O/H) and nitrogen abundance gradients traced by star-forming regions in a representative sample of 550 nearby galaxies in the stellar mass range ...109–1011.5 M⊙ with resolved spectroscopic data from the Sloan Digital Sky Survey IV Mapping Nearby Galaxies at Apache Point Observatory survey. Using strong-line ratio diagnostics (R23 and O3N2 for metallicity and N2O2 for N/O) and referencing to the effective (half-light) radius (Re), we find that the metallicity gradient steepens with stellar mass, lying roughly flat among galaxies with log (M⋆/M⊙) = 9.0 but exhibiting slopes as steep as −0.14 dex $R_{\rm e}^{-1}$ at log (M⋆/M⊙) = 10.5 (using R23, but equivalent results are obtained using O3N2). At higher masses, these slopes remain typical in the outer regions of our sample (R > 1.5Re), but a flattening is observed in the central regions (R < 1Re). In the outer regions (R > 2.0Re), we detect a mild flattening of the metallicity gradient in stacked profiles, although with low significance. The N/O ratio gradient provides complementary constraints on the average chemical enrichment history. Unlike the oxygen abundance, the average N/O profiles do not flatten out in the central regions of massive galaxies. The metallicity and N/O profiles both depart significantly from an exponential form, suggesting a disconnect between chemical enrichment and stellar mass surface density on local scales. In the context of inside-out growth of discs, our findings suggest that central regions of massive galaxies today have evolved to an equilibrium metallicity, while the nitrogen abundance continues to increase as a consequence of delayed secondary nucleosynthetic production.
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