An assessment was made of the determination of carcinoembryonic antigen (CEA) in patients with tumours and non-neoplastic diseases. Positivity in relation to hepatic cirrhosis and stasis was noted in ...only 3.9% of non-oncological patients, whereas this figure rose to 28.8% in those with tumors, with higher frequencies in forms involving the intestine, lung, liver, and stomach. Variations in the result of the examination were noted in relation to the progress of the disease, and also in relation to chemotherapy in some cases. The results of the investigation indicate that CEA is of little use as an early diagnosis test. Its importance lies in its indication of the effectiveness of treatment, and as an early sign of the approach of recurrences.
Oligonucleotide-directed triple helix formation represents a promising approach to block gene expression at the transcriptional level. We have previously shown 10 that a triple-helix-forming ...oligonucleotide was able to inhibit promoter function of reporter constructs in live cells, provided that the oligonucleotide was covalently linked to an intercalating agent which stabilizes triple-helical complexes. In order to demonstrate that this inhibitory effect was due to triple helix formation, we have mutated the oligonucleotide target site in the promoter of the interleukin-2 receptor alpha-chain gene. The mutated version of the promoter does not bind, and is not inhibited by the oligonucleotide, demonstrating that the observed inhibition of the wild-type promoter is indeed due to triple helix formation within cells.
The HERA electron--proton collider has collected 100 pb$^{-1}$ of data since
its start-up in 1992, and recently moved into a high-luminosity operation mode,
with upgraded detectors, aiming to ...increase the total integrated luminosity per
experiment to more than 500 pb$^{-1}$. HERA has been a machine of excellence
for the study of QCD and the structure of the proton. The Large Hadron Collider
(LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will
be completed at CERN in 2007. The main mission of the LHC is to discover and
study the mechanisms of electroweak symmetry breaking, possibly via the
discovery of the Higgs particle, and search for new physics in the TeV energy
scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC
will also make a substantial number of precision measurements and will offer a
new regime to study the strong force via perturbative QCD processes and
diffraction. For the full LHC physics programme a good understanding of QCD
phenomena and the structure function of the proton is essential. Therefore, in
March 2004, a one-year-long workshop started to study the implications of HERA
on LHC physics. This included proposing new measurements to be made at HERA,
extracting the maximum information from the available data, and
developing/improving the theoretical and experimental tools. This report
summarizes the results achieved during this workshop.
The HERA electron--proton collider has collected 100 pb$^{-1}$ of data since
its start-up in 1992, and recently moved into a high-luminosity operation mode,
with upgraded detectors, aiming to ...increase the total integrated luminosity per
experiment to more than 500 pb$^{-1}$. HERA has been a machine of excellence
for the study of QCD and the structure of the proton. The Large Hadron Collider
(LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will
be completed at CERN in 2007. The main mission of the LHC is to discover and
study the mechanisms of electroweak symmetry breaking, possibly via the
discovery of the Higgs particle, and search for new physics in the TeV energy
scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC
will also make a substantial number of precision measurements and will offer a
new regime to study the strong force via perturbative QCD processes and
diffraction. For the full LHC physics programme a good understanding of QCD
phenomena and the structure function of the proton is essential. Therefore, in
March 2004, a one-year-long workshop started to study the implications of HERA
on LHC physics. This included proposing new measurements to be made at HERA,
extracting the maximum information from the available data, and
developing/improving the theoretical and experimental tools. This report
summarizes the results achieved during this workshop.
Mesoglycan is a natural glycosaminoglycans preparation, with antithrombotic and pro-fibrinolytic activities, which has been shown to be clinically effective in a number of vascular atherosclerotic ...disorders with thrombotic risk.
In the present investigation we studied the effect of mesoglycan in patients with acute episodes of relative lower limb ischemia (Stage IIb according to Leriche-Fontaine classification) coming to our observation. Mesoglycan was administered according to the following schedule: a 10-days period of endovenous mesoglycan (90 mg/day), given in day-hospital regimen, followed by a 20-days period of oral mesoglycan (100 mg/day). The treatment schedule was repeated for two months and then patient continued with oral mesoglycan. We present the preliminary results obtained on 36 patients which were followed for a mean period of 12 months.
From February 1995 thirty-six patients, 24 males and 12 females, aged between 45 and 83 years (mean +/- SD: 69.8 +/- 7.5) coming to our observation for acute relative lower limb ischemia were enrolled. At baseline, the diagnosis was Fontaine's IIb stage (walking distance < or = 200 m) in all patients, 17 patients presenting walking distance < 100 m. After 3 and 6 months of mesoglycan treatment a significant improvement of symptoms and signs was observed in all patients but one. At the end of the 6-months period, 29 patients (81% of the study population) became to a Fontaine's IIa degree, with a significant increase in walking distance (in 70% three times their basal value) and improvement of symptoms and recovery time. After treatment, Winsor Index was not significantly modified. Similar results were obtained after 12 months of follow-up. During the study period only one patient included in the trial needed surgical revascularisation. The administration of mesoglycan was well tolerated, with only minor complaints in two patients (one case of headache and one of diarrhea). During the endovenous administration of mesoglycan most patients (81%) presented values of aPTT almost double than baseline, which returned to normal values at the end of the administration.
The present preliminary results show that, in patients with acute episodes of relative lower limb ischemia, mesoglycan (administered according to the described protocol) is an effective and safe agent able to improve symptoms (walking distance, pain, leg appearance) and to possibly delay the need of surgical interventions.
In a patient with intralobar pulmonary sequestration the presenting feature was severe hemothorax caused by rupture of the anomalous artery. Only one previous case with this presentation was found in ...the literature. During operation for intralobar sequestration, the blood vessels of the anomaly must be clearly visualized, in order to avoid further complications. When the condition is suspected, angiography is mandatory for establishment of the diagnosis.
The HERA electron--proton collider has collected 100 pb\(^{-1}\) of data since its start-up in 1992, and recently moved into a high-luminosity operation mode, with upgraded detectors, aiming to ...increase the total integrated luminosity per experiment to more than 500 pb\(^{-1}\). HERA has been a machine of excellence for the study of QCD and the structure of the proton. The Large Hadron Collider (LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will be completed at CERN in 2007. The main mission of the LHC is to discover and study the mechanisms of electroweak symmetry breaking, possibly via the discovery of the Higgs particle, and search for new physics in the TeV energy scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC will also make a substantial number of precision measurements and will offer a new regime to study the strong force via perturbative QCD processes and diffraction. For the full LHC physics programme a good understanding of QCD phenomena and the structure function of the proton is essential. Therefore, in March 2004, a one-year-long workshop started to study the implications of HERA on LHC physics. This included proposing new measurements to be made at HERA, extracting the maximum information from the available data, and developing/improving the theoretical and experimental tools. This report summarizes the results achieved during this workshop.
The HERA electron--proton collider has collected 100 pb\(^{-1}\) of data since its start-up in 1992, and recently moved into a high-luminosity operation mode, with upgraded detectors, aiming to ...increase the total integrated luminosity per experiment to more than 500 pb\(^{-1}\). HERA has been a machine of excellence for the study of QCD and the structure of the proton. The Large Hadron Collider (LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will be completed at CERN in 2007. The main mission of the LHC is to discover and study the mechanisms of electroweak symmetry breaking, possibly via the discovery of the Higgs particle, and search for new physics in the TeV energy scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC will also make a substantial number of precision measurements and will offer a new regime to study the strong force via perturbative QCD processes and diffraction. For the full LHC physics programme a good understanding of QCD phenomena and the structure function of the proton is essential. Therefore, in March 2004, a one-year-long workshop started to study the implications of HERA on LHC physics. This included proposing new measurements to be made at HERA, extracting the maximum information from the available data, and developing/improving the theoretical and experimental tools. This report summarizes the results achieved during this workshop.
