Located between the on-detector front-end electronics and the global data acquisition system (DAQ), the off-detector electronics of the CMS electromagnetic calorimeter (ECAL) is involved in both ...detector readout and trigger system. Working at 40 MHz, the trigger part must, within 10 clock cycles, receive and deserialise the data of the front-end electronics, encode the trigger primitives using a non linear scale, assure time alignment between channels using a histogramming technique and send the trigger primitives to the regional trigger. In addition, it must classify trigger towers in three classes of interest and send this classification to the readout part. The readout part must select the zero suppression level to apply depending on the regions of interest determined from the trigger tower classification, deserialise front-end data coming from high-speed (800 Mbit/s) serial links, check their integrity, apply zero suppression, build the event and send it to the DAQ, monitor the buffer occupancy and send back pressure to the trigger system when required, provide data spying and monitoring facilities for the local DAQ. The system, and especially the data link speed, the latency constraints and the bit error rate requirements have been validated on prototypes. Part of the system is about to go to production.
The plasma beat-wave acceleration experiment at Ecole Polytechnique Amiranoff, F.; Ardonceau, J.; Bercher, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/1995, Letnik:
363, Številka:
3
Journal Article
Recenzirano
Odprti dostop
We present an experiment for demonstrating the principle of plasma beat-wave acceleration. The beating of two Nd-laser pulses creates a relativistic plasma wave in a deuterium plasma. Electrons at an ...energy of 3 MeV are injected into the plasma. We observe several hundred electrons accelerated up to 3.7 MeV.
This paper is mainly devoted to the description of the experimental apparatus. In the design of the apparatus, we gave particular attention to efficient electron injection and to background noise suppression. We present also some preliminary results of electron acceleration experiments.
Systemic Lupus Erythematosus (SLE) is a progressive disease leading to immune-mediated tissue damage, associated with an alteration of lymphoid organs. Therapeutic strategies involving regulatory T ...(Treg) lymphocytes, which physiologically quench autoimmunity and support long-term immune tolerance, are considered, as conventional treatment often fails. We describe here a therapeutic strategy based on Tregs overexpressing FoxP3 and harboring anti-CD19 CAR (Fox19CAR-Tregs). Fox19CAR-Tregs efficiently suppress proliferation and activity of B cells in vitro, which are relevant for SLE pathogenesis. In an humanized mouse model of SLE, a single infusion of Fox19CAR-Tregs restricts autoantibody generation, delay lymphopenia (a key feature of SLE) and restore the human immune system composition in lymphoid organs, without detectable toxicity. Although a short survival, SLE target organs appear to be protected. In summary, Fox19CAR-Tregs can break the vicious cycle leading to autoimmunity and persistent tissue damage, representing an efficacious and safe strategy allowing restoration of homeostasis in SLE.
A Ni/1-bpp catalyst was demonstrated to be effective in the Negishi alkylation with multiple classes of alkylpyridinium salts, including α-primary and α-secondary. These conditions are also effective ...for benzylic pyridinium salts, demonstrating the successful Negishi alkylation of benzylic pyridinium salts for the first time. Further, 14 derivatives of 1-bpp were prepared with a variety of steric and electronic properties to study how these changes impact the success of the Negishi alkylation.
PUVA--therapy with low UV-A dose Hesse, G; Wichmann-Hesse, A C; Bercher, M
H + G. Zeitschrift für Hautkrankheiten,
1987-Jun-15, Letnik:
62, Številka:
12
Journal Article
A long-term study on 98 psoriatic patients with an average observation time of seven years proved that PUVA therapy with low doses of UV-A is sufficient to induce complete remission of psoriasis ...vulgaris (chronic stationary type). After a maintenance therapy of about 7.3 irradiations over 6.5 weeks, the patients were without symptoms for 64 weeks on an average. With regard to patients showing skin type II, III, or IV, we give detailed information on the increase of UV-A doses during the first eleven days of treatment.
PDF
