Human activities and city routines follow patterns. Transfer learning can help achieve scalable solutions toward the realization of smart cities accounting for similarities between regions, domains, ...and activities. In this study, we propose a transfer learning-based framework for smart buildings to test this hypothesis in energy-related problems. Our framework has two major components: the network creation and the transferable predictive model. In order to create the network that groups buildings sharing characteristics, we evaluated two strategies: a novel clustering algorithm for mixed data, k -prod, and clustering the image-based representation of time series. Then, a combination of long short term memory and convolutional neural network was trained on the centroids of the clusters for energy consumption prediction. The coefficient of variation of the root mean squared error (CVRMSE) of the predictions in such clusters vary between 3.85% and 58.85%. The obtained parameters were transferred to the rest of the buildings for predictive purposes, finding accurate results in buildings with little data. Our framework deals with insufficient training data since parameters from scenarios with more sensors can be received. It also carries out state-of-the-art performance on three datasets from different sources having in total 533 rooms/buildings and two energy efficiency domains: consumption prediction reducing the CVRMSE in a 21.6%, and air conditioning usage prediction moving from a 4.18% to a 0.28% CVRMSE. Our framework extracts more knowledge from available IoT deployments, so that smartness could be spread between environments at a fewer cost given that less individual effort will be needed.
Mesenchymal stem cell (MSC) transplantation is emerging as an ideal tool to restore the wounded central nervous system (CNS). MSCs isolated from extra-embryonic tissues have some advantages compared ...to MSCs derived from adult ones, such as an improved proliferative capacity, life span, differentiation potential and immunomodulatory properties. In addition, they are more immunoprivileged, reducing the probability of being rejected by the recipient. Umbilical cords (UCs) are a good source of MSCs because they are abundant, safe, non-invasively harvested after birth and, importantly, they are not encumbered with ethical problems. Here we show that the intravitreal transplant of Wharton´s jelly mesenchymal stem cells isolated from three different human UCs (hWJMSCs) delays axotomy-induced retinal ganglion cell (RGC) loss. In vivo, hWJMSCs secrete anti-inflammatory molecules and trophic factors, the latter alone may account for the elicited neuroprotection. Interestingly, this expression profile differs between naive and injured retinas, suggesting that the environment in which the hWJMSCs are modulates their secretome. Finally, even though the transplant itself is not toxic for RGCs, it is not innocuous as it triggers a transient but massive infiltration of Iba1
cells from the choroid to the retina that alters the retinal structure.
The aim of this study was to investigate, the neuroprotective effects of a new Gramine derivative named: ITH12657, in a model of retinal excitotoxicity induced by intravitreal injection of NMDA.
...Adult Sprague Dawley rats received an intravitreal injection of 100 mM NMDA in their left eye and were treated daily with subcutaneous injections of ITH12657 or vehicle. The best dose-response, therapeutic window study, and optimal treatment duration of ITH12657 were studied. Based on the best survival of Brn3a + RGCs obtained from the above-mentioned studies, the protective effects of ITH12657 were studied
(retinal thickness and full-field Electroretinography), and
by quantifying the surviving population of Brn3a + RGCs, αRGCs and their subtypes α-ONsRGCs, α-ONtRGCs, and α-OFFRGCs.
Administration of 10 mg/kg ITH12657, starting 12 h before NMDA injection and dispensed for 3 days, resulted in the best significant protection of Brn3a + RGCs against NMDA-induced excitotoxicity.
, ITH12657-treated rats showed significant preservation of retinal thickness and functional protection against NMDA-induced retinal excitotoxicity.
results showed that ITH12657 afforded a significant protection against NMDA-induced excitotoxicity for the populations of Brn3a + RGC, αRGC, and αONs-RGC, but not for the population of αOFF-RGC, while the population of α-ONtRGC was fully resistant to NMDA-induced excitotoxicity.
Subcutaneous administration of ITH12657 at 10 mg/kg, initiated 12 h before NMDA-induced retinal injury and continued for 3 days, resulted in the best protection of Brn3a + RGCs, αRGC, and αONs-RGC against excitotoxicity-induced RGC death. The population of αOFF-RGCs was extremely sensitive while α-ONtRGCs were fully resistant to NMDA-induced excitotoxicity.
Scope
Plasma fatty acids (FAs) are associated with the development of cardiovascular diseases and metabolic syndrome. The aim of our study is to assess the relationship between fruit and vegetable ...(F&V) consumption and plasma FAs and their subtypes.
Methods and Results
Plasma FAs are assessed in a cross‐sectional analysis of a subsample of 240 subjects from the PREDIMED‐Plus study. Participants are categorized into four groups of fruit, vegetable, and fat intake according to the food frequency questionnaire. Plasma FA analysis is performed using gas chromatography. Associations between FAs and F&V consumption are adjusted for age, sex, physical activity, body mass index (BMI), total energy intake, and alcohol consumption. Plasma saturated FAs are lower in groups with high F&V consumption (‐1.20 mg cL−1 95% CI: ‐2.22, ‐0.18, p‐value = 0.021), especially when fat intake is high (‐1.74 mg cL−1 95% CI: ‐3.41, ‐0.06, p‐value = 0.042). Total FAs and n‐6 polyunsaturated FAs tend to be lower in high consumers of F&V only in the high‐fat intake groups.
Conclusions
F&V consumption is associated with lower plasma saturated FAs when fat intake is high. These findings suggest that F&V consumption may have different associations with plasma FAs depending on their subtype and on the extent of fat intake.
The relationship between fruit and vegetable consumption and fatty acids and their subtypes remains unknown. In this cross‐sectional substudy of the PREDIMED‐Plus Study, participants are categorized according to fat, fruits and vegetables consumption. Fruit and vegetable consumption is associated with lower plasma saturated fatty acids when fat intake is high.
•Highlights should be submitted in a separate editable file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, ...including spaces, per bullet point).•SOT recipients vs. no SOT patients have more undetectable IFN-γ and RNAemia rates.•Undetectable IFN-α rates are similar in SOT recipients and in no SOT patients.•In the no SOT patients, RNAemia and mortality decreased after 10 days of disease.•RNAemia is associated with unfavorable outcome in SOT recipients.•RNAemia and undetectable IFN-γ are associated with mortality in no SOT patients.
Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns.
The aim of this study was to assess the association between the adherence ...to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight.
Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m
(55-75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1: <10%,
= 1495; Q2: 10-15%,
= 1804; Q3: <15-20%,
= 1470; Q4: ≥20%,
= 1589). Diet was assessed using a validated food frequency questionnaire and a 17-item Mediterranean diet questionnaire. Physical activity was assessed by the validated Minnesota-REGICOR and the validated Spanish version of the Nurses' Health Study questionnaire.
Participants reporting higher percentages of desired weight loss (Q3 and Q4) were younger, had higher real and perceived BMI and were more likely to have abdominal obesity. Desired weight loss correlated inversely to physical activity (Q1: 2106 MET min/week; Q4: 1585 MET min/week.
< 0.001) and adherence to Mediterranean diet (Q1: 8.7; Q4: 8.3.
< 0.001).
In older Mediterranean individuals with weight excess, desired weight loss was inversely associated with Mediterranean lifestyle adherence. Deeply rooted aspects of the MedDiet remained similar across groups. Longitudinal research is advised to be able to establish causality.
The purpose of our work is to leverage the use of artificial intelligence for the emergence of smart greenhouses. Greenhouse agriculture is a sustainable solution for food crises and therefore ...data-based decision-support mechanisms are needed to optimally use them. Our study anticipates how the combination of climatic systems will affect the temperature and humidity of the greenhouse. More specifically, our methodology anticipates if a set-point will be reached in a given time by a combination of climatic systems and estimates the humidity at that time. We performed exhaustive data analytics processing that includes the interpolation of missing values and data augmentation, and tested several classification and regression algorithms. Our method can predict with a 90% accuracy if, under current conditions, a combination of climatic systems will reach a fixed temperature set-point, and it is also able to estimate the humidity with a 2.83% CVRMSE. We integrated our methodology on a three-layer holistic IoT platform that is able to collect, fuse and analyze real data in a seamless way.
Abstract
Background
In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this ...study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests.
Methods
In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake.
Results
After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median IQR; 194.4 μg/d 120.9, 373.1) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR 95% CI; 0.53 0.35, 0.79 P for trend = 0.002) compared with a decrease in the intake of vitamin K (median IQR; −97.8 μg/d −292.8, −51.5). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR 95% CI; 0.69 0.51, 0.94 P for trend = 0.019) was found.
Conclusions
An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.
Objective
The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross‐sectional assessment of PREDIMED‐Plus trial participants ...at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined.
Methods
A total of 6,874 individuals aged 55 to 75 with BMI ≥ 27 and < 40 kg/m2 were included and classified by presence (HTGW+) or absence (HTGW−) of HTGW (waist circumference: men ≥ 102 cm, women ≥ 88 cm; fasting plasma triglycerides ≥ 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed.
Results
A total of 38.2% of the sample met HTGW+ criteria. HTGW+ individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low‐density lipoprotein cholesterol levels; had lower high‐density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW− patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW+.
Conclusions
HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW− individuals were more physically active with greater total physical activity, and fewer had hypertension.
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