Alimentary atherosclerosis is associated with a significant decrease in the content of phosphatidylcholine, the phospholipid that provides antioxidant protection, in the plasma membrane of liver ...cells, while the level of phosphatidic acid that initiates generation of superoxides, on the contrary, increases. The level of membrane phosphatidylserine, a target of the scavenger receptors, which initiates removal of damaged cells and modified lipoproteins from the circulation was also elevated. In the blood serum of rabbits receiving an atherogenic diet, the content of cardiolipin involved in the immune mechanisms of atherosclerosis development and a risk factor for thrombosis, sharply increased. The level of lysophosphatidylcholine that mediates initiation and progression of atherosclerosis increased. The content of phosphatidylinositol that is involved in the mechanisms protecting from exposure to excess cholesterol was significantly reduced. Treatment of alimentary atherosclerosis with “empty” phosphatidylcholine nanosomes eliminates the key factors initiating atherosclerosis development.
The results of experimental study of morphology of silver nanostructures, which appear during thermal destruction of polyvinyl alcohol film with silver nitrate are presented. It is shown that during ...the increase of silver nitrate concentration the maximum size of the formed particles increases from tens of nanometers up to 2 μm, and their shape transforms from spherical to irregular. The growth of silver nanoparticles occurs at the expense of small silver nanoparticles migration on a substrate surface, their gathering near the large nanoparticles and confluence of small nanoparticles with larger ones.
Summary
Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the ...largest genome‐wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project. In the joint linkage analyses, we observed four regions that show linkage with longevity; chromosome 14q11.2 (LOD = 3.47), chromosome 17q12‐q22 (LOD = 2.95), chromosome 19p13.3‐p13.11 (LOD = 3.76), and chromosome 19q13.11‐q13.32 (LOD = 3.57). To fine map these regions linked to longevity, we performed association analysis using GWAS data in a subgroup of 1228 unrelated nonagenarian and 1907 geographically matched controls. Using a fixed‐effect meta‐analysis approach, rs4420638 at the TOMM40/APOE/APOC1 gene locus showed significant association with longevity (P‐value = 9.6 × 10−8). By combined modeling of linkage and association, we showed that association of longevity with APOEε4 and APOEε2 alleles explain the linkage at 19q13.11‐q13.32 with P‐value = 0.02 and P‐value = 1.0 × 10−5, respectively. In the largest linkage scan thus far performed for human familial longevity, we confirm that the APOE locus is a longevity gene and that additional longevity loci may be identified at 14q11.2, 17q12‐q22, and 19p13.3‐p13.11. As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity.
A significant increase in the recording speed of very long baseline radio interferometry (VLBI) data and, accordingly, their volume (on the order of several hundred terabytes) requires reliable ...storage of these data for the possibility of repeated processing. An array of disk drives with redundancy can serve as one of the options for a reliable fault-tolerant long-term storage system for VLBI data (RAID is Redundant Array of Independent Disks). This paper presents the results of a study of the reliability of RAID software in the implementation of the ZFS file system (Zettabyte File System) in the raidz and raidz2 variants (analogs of RAID5 and RAID6) of the VLBI data storage system using the example of standard server equipment, and recommendations for creating such a system for long-term storage of this data in the correlation processing center of the RAS.
Introduction.
Percutaneous nephrolitholapaxy (PNL) is the optimal method in the treatment of large or complex renal stones. Surgical equipment and endoscopic equipment, and specialised tools have ...been constantly developing since the advent of PNL in 1976, increasing success rates with a decrease in the number of complications and morbidity. Owing to the specificity and complexity of the technique, only 11% of urologists in the USA perform PNL, while in Russian Federation no more than 5% of specialists realise it.
Objective.
To evaluate the possibilities of using a robot-angiograph to create a puncture access.
Materials & methods
. In the Krasnoyarsk Regional Clinical Hospital in 2021, the first PNL was performed in a patient with a left-sided lower calyx stone using the SIEMENS Healthineers’ ARTIS pheno robotic angiograph in a hybrid operating room. This robotic installation allows the performing of an intraoperative computed tomography examination followed by the construction of a navigation map with a clearly displayed trajectory, length, and angle of inclination of the needle path with automatic positioning of the C-arm.
Results.
We performed 30 pyelocaliceal punctures using a robotic angiographic installation for PNL. The average age of patients was 56.6 ± 19.0 years. According to MSCT, the lower calyx stone was detected in seven patients, the middle calyx — 13 cases, the upper calyx — seven patients, pelvic stones were recorded in three patients. The density of stones varied from 877 HU to 1356 HU. The use of the ARTIS pheno robotic system allows performing intraoperative 3D modelling to determine the safest pyelocaliceal puncture, followed by PNL, regardless of the stone localisation, the complexity of the anatomy. In addition, a CT-like scans allows you to assess the presence of residual stones during the operation and perform a "second look" not in a delayed manner. This system, unlike all existing types of navigation, allows intraoperative evaluation of the effectiveness (stone-free rate) of surgical treatment.
Conclusion.
The introduction of this navigation system in PNL will minimise the risks of complications from puncture access, reduce the number of repeated interventions, and minimise undesirable consequences in the postoperative period.
Zirconium β-diketonates (synthesized dipivaloylmethanate and commercially available acetylacetonate) have been studied to obtain low-background Zr-containing liquid organic scintillators. Their ...solubility in organic solvents—linear alkylbenzene and pseudocumene—has been studied. Light absorption in pseudocumene and hexane and specific light yield of scintillator with added β-diketonates depending on zirconium concentration and scintillation additives has been measured. It has been shown that the specific light yield of scintillator has a high value (>60%) only at low zirconium concentration (not higher 2.5 g/L).
A method for evaluation of the performance of the disk subsystem of a data buffering and transmission system and results of experimental studies of the performance of the disk subsystem according to ...the developed method are presented. A conclusion is drawn on the reasonability of the use of hard-disk drives that provide the required read/write rates with a sufficiently high level of reliability in prospective development of the modern high-capacity NearLine SAS (NL-SAS).
The fragmentation of projectiles penetrating into thin discrete bumpers is accompanied by material ejections from the front part of the projectile in the direction of its movement. Material ejections ...from the front part of the projectile and fragments from the rear part of the projectile form two groups of fragments. The distribution of craters formed by these groups of fragments was analyzed; the intensity and nature of the damage they caused and the effect of projectile velocity on the kinetic energy distribution between these groups were determined. Fragments were captured using witness plates of great thicknesses placed at a certain distance behind the steel mesh bumper on the path of movement of fragments. It was found that with an increase in velocity, the fraction of the specific kinetic energy of front ejections increased and the fraction of the kinetic energy of fragments from the rear of the projectile decreased. The kinetic energy distribution was determined in the case of fragmentation of an aluminum alloy projectile of 9 mm diameter on a tungsten mesh (wire diameter 0.5 mm, aperture 3.2 mm). The ration of the diameter of the projectile to the cell size of the tungsten mesh was the same as for the steel mesh. The kinetic energy distributions for tungsten and steel meshes were found to be significantly different, probably due to the strength characteristics of the projectile material and the smaller wire diameter in experiments with tungsten meshes. The damage pattern to the witness plate by a group of small fragments was analyzed.
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