A
bstract
The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies
s
= 380 GeV, ...1
.
5 TeV, and 3 TeV. Its aim is to explore the energy frontier, providing sensitivity to physics beyond the Standard Model (BSM) and precision measurements of Standard Model processes with an emphasis on Higgs boson and top-quark physics. The opportunities for top-quark physics at CLIC are discussed in this paper. The initial stage of operation focuses on top-quark pair production measurements, as well as the search for rare flavour-changing neutral current (FCNC) top-quark decays. It also includes a top-quark pair production threshold scan around 350 GeV which provides a precise measurement of the top-quark mass in a well-defined theoretical framework. At the higher-energy stages, studies are made of top-quark pairs produced in association with other particles. A study of t
̄
tH production including the extraction of the top Yukawa coupling is presented as well as a study of vector boson fusion (VBF) production, which gives direct access to high-energy electroweak interactions. Operation above 1 TeV leads to more highly collimated jet environments where dedicated methods are used to analyse the jet constituents. These techniques enable studies of the top-quark pair production, and hence the sensitivity to BSM physics, to be extended to higher energies. This paper also includes phenomenological interpretations that may be performed using the results from the extensive top-quark physics programme at CLIC.
The Compact Linear Collider (CLIC) is an option for a future
e
+
e
-
collider operating at centre-of-mass energies up to
3
TeV
, providing sensitivity to a wide range of new physics phenomena and ...precision physics measurements at the energy frontier. This paper is the first comprehensive presentation of the Higgs physics reach of CLIC operating at three energy stages:
s
=
350
GeV
, 1.4 and
3
TeV
. The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung (
e
+
e
-
→
Z
H
) and
W
W
-fusion (
e
+
e
-
→
H
ν
e
ν
¯
e
), resulting in precise measurements of the production cross sections, the Higgs total decay width
Γ
H
, and model-independent determinations of the Higgs couplings. Operation at
s
>
1
TeV
provides high-statistics samples of Higgs bosons produced through
W
W
-fusion, enabling tight constraints on the Higgs boson couplings. Studies of the rarer processes
e
+
e
-
→
t
t
¯
H
and
e
+
e
-
→
H
H
ν
e
ν
¯
e
allow measurements of the top Yukawa coupling and the Higgs boson self-coupling. This paper presents detailed studies of the precision achievable with Higgs measurements at CLIC and describes the interpretation of these measurements in a global fit.
•Arbidol (ARB) is licensed in Russia and China for the treatment of influenza and other viral infections.•ARB inhibits a large panel of viral pathogens, enveloped or not.•ARB displays a dual binding ...activity to lipid membranes and to viral or cellular proteins.•It blocks viral endocytosis and replication in membranous intracellular compartments.
Arbidol (ARB) is a Russian-made small indole-derivative molecule, licensed in Russia and China for prophylaxis and treatment of influenza and other respiratory viral infections. It also demonstrates inhibitory activity against other viruses, enveloped or not, responsible for emerging or globally prevalent infectious diseases such as hepatitis B and C, gastroenteritis, hemorrhagic fevers or encephalitis. In this review, we will explore the possibility and pertinence of ARB as a broad-spectrum antiviral, after a careful examination of its physico-chemical properties, pharmacokinetics, toxicity, and molecular mechanisms of action. Recent studies suggest that ARB’s dual interactions with membranes and aromatic amino acids in proteins may be central to its broad-spectrum antiviral activity. This could impact on the virus itself, and/or on cellular functions or critical steps in virus-cell interactions, thereby positioning ARB as both a direct-acting antiviral (DAA) and a host-targeting agent (HTA). In the context of recent studies in animals and humans, we will discuss the prospective clinical use of ARB in various viral infections.
(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image) Abstract The determination of scalar lepton and gaugino masses is an important part of the programme of spectroscopic ...studies of Supersymmetry at a high energy e ^sup +^ e ^sup -^ linear collider. In this article we present results of a study of the processes: e ^sup +^ e ^sup -^ arrow right ... arrow right e ^sup +^ e ^sup -^ ..., e ^sup +^ e ^sup -^ arrow right ... arrow right mu ^sup +^ mu ^sup -^ ..., e ^sup +^ e ^sup -^ arrow right ... arrow right e ^sup +^ e ^sup -^ ... and e ^sup +^ e ^sup -^ arrow right ... arrow right e ^sup +^ e ^sup -^ ... in two Supersymmetric benchmark scenarios at ... =3 TeV and 1.4 TeV at CLIC. We characterize the detector performance, lepton energy resolution and boson mass resolution. We report the accuracy of the production cross section measurements and the ... , ... , ... , ..., and ... mass determinations, estimate the systematic errors affecting the mass measurement and discuss the requirements on the detector time stamping capability and beam polarization. The analysis accounts for the CLIC beam energy spectrum and the dominant beam-induced background. The detector performances are incorporated by full simulation and reconstruction of the events within the framework of the CLIC ILD CDR detector concept.
Summary
Hepatitis C virus (HCV) is a global health concern infecting 170 million people worldwide. Previous studies indicate that the extract from milk thistle known as silymarin and its main ...component silibinin inhibit HCV infection. Here we investigated the mechanism of anti‐HCV action ofsilymarin‐derived compounds at the molecular level. By using live‐cell confocal imaging, single particle tracking, transmission electron microscopy and biochemical approaches on HCV‐infected human hepatoma cells and primary hepatocytes, we show that silibinin potently inhibits HCV infection and hinders HCV entry by slowing down trafficking through clathrin‐coated pits and vesicles. Detailed analyses revealed that silibinin altered the formation of both clathrin‐coated pits and vesicles in cells and caused abnormal uptake and trafficking of transferrin, a well‐known cargo of the clathrin endocytic pathway. Silibinin also inhibited infection by other viruses that enter cells by clathrin‐mediated endocytosis including reovirus, vesicular stomatitis and influenza viruses. Our study demonstrates that silibinin inhibits HCV early steps of infection by affecting endosomal trafficking of virions. It provides new insights into the molecular mechanisms of action of silibinin against HCV entry and also suggests that silibinin is a potential broad‐spectrum antiviral therapy.
•Arbidol is a broad-spectrum antiviral known as an entry and fusion inhibitor.•We investigate its mechanism of action on cells by live-cell confocal imaging.•Arbidol affects clathrin-mediated ...endocytosis.•This leads to confinement of viral particles in clathrin-coated vesicles.•Arbidol acts by impeding dynamin-induced membrane scission.
Arbidol (ARB) is a broad-spectrum antiviral displaying activity against a number of enveloped and non-enveloped viruses. It was described as a viral entry inhibitor and shown to interact at the molecular level with lipid membranes and viral fusion glycoproteins to impede viral entry and fusion. However its mechanism of action at the cellular level remains unknown. Here, by using live-cell confocal imaging and the hepatitis C virus as a model virus, we show that ARB affects clathrin-mediated endocytosis by impeding dynamin-2-induced membrane scission. Moreover it induces the intracellular accumulation of clathrin-coated structures where viral particles are trapped. Collectively, our results shed light on the mechanistic aspects of ARB antiviral activity and suggest that ARB could prevent cell infection by viruses that enter through clathrin-mediated endocytosis.
The determination of scalar lepton and gaugino masses is an important part of the programme of spectroscopic studies of Supersymmetry at a high energy e+e- linear collider. In this article we present ...results of a study of the processes: e+e- -> eR eR -> e+e- chi0 chi, e+e- -> muR muR -> mu mu- chi0 chi0, e+e- -> eL eL -> e e chi0 chi0 and e+e- -> snu_e snu_e -> e e chi+ chi-in two Supersymmetric benchmark scenarios at 3 TeV and 1.4 TeV at CLIC. We characterize the detector performance, lepton energy resolution and boson mass resolution. We report the accuracy of the production cross section measurements and the eR muR, snu_e, chi+ and chi0 mass determination, estimate the systematic errors affecting the mass measurement and discuss the requirements on the detector time stamping capability and beam polarization. The analysis accounts for the CLIC beam energy spectrum and the dominant beam-induced background. The detector performances are incorporated by full simulation and reconstruction of the events within the framework of the CLIC_ILD_CDR detector concept.
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