Marine natural products Blunt, John W; Carroll, Anthony R; Copp, Brent R ...
Natural product reports,
01/2018, Letnik:
35, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period ...January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports,
03/2017, Letnik:
34, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period ...January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports,
03/2016, Letnik:
33, Številka:
3
Journal Article
Recenzirano
Odprti dostop
This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine ...microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports,
02/2015, Letnik:
32, Številka:
2
Journal Article
Recenzirano
Odprti dostop
This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine ...microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
The Benefits of Collaboration Blunt, John W; Munro, Murray H G
Marine drugs,
01/2023, Letnik:
21, Številka:
2
Journal Article
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We have been very humbled by the decision of the
Editors to honor us with a Special Issue dedicated to our efforts over the past 50 years, as well as their invitation to write a guest editorial for ...this issue ....
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports
30, Številka:
2
Journal Article
Recenzirano
This review covers the literature published in 2011 for marine natural products, with 870 citations (558 for the period January to December 2011) referring to compounds isolated from marine ...microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1152 for 2011), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
Objective
Dietary supplements and alternative therapies are commercialized as a panacea for obesity/weight gain as a result of the minimal regulatory requirements in demonstrating efficacy. These ...products may indirectly undermine the value of guideline‐driven obesity treatments. Included in this study is a systematic review of the literature of purported dietary supplements and alternative therapies for weight loss.
Methods
A systematic review was conducted to evaluate the efficacy of dietary supplements and alternative therapies for weight loss in participants aged ≥18 years. Searches of Medline (PubMed), Cochrane Library, Web of Science, CINAHL, and Embase (Ovid) were conducted. Risk of bias and results were summarized qualitatively.
Results
Of the 20,504 citations retrieved in the database search, 1,743 full‐text articles were reviewed, 315 of which were randomized controlled trials evaluating the efficacy of 14 purported dietary supplements, therapies, or a combination thereof. Risk of bias and sufficiency of data varied widely. Few studies (n = 52 16.5%) were classified as low risk and sufficient to support efficacy. Of these, only 16 (31%) noted significant pre/post intergroup differences in weight (range: 0.3‐4.93 kg).
Conclusions
Dietary supplements and alternative therapies for weight loss have a limited high‐quality evidence base of efficacy. Practitioners and patients should be aware of the scientific evidence of claims before recommending use.
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports,
01/2014, Letnik:
31, Številka:
2
Journal Article
Recenzirano
Odprti dostop
This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine ...microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
Aim
The aim of this study is to provide a robust estimate of mortality risk in acute coronary syndrome (ACS)‐associated acute kidney injury (AKI) to inform clinical practice and policy.
Methods
A ...meta‐analysis of cohort studies evaluating outcomes of ACS and which reported AKI and AKI‐associated mortality. Studies were excluded if they incorporated patients not admitted through the emergency department (i.e. for elective procedures), were limited to cardiogenic shock or cardiac arrest, or relied on registry data for outcomes without further adjudication. The predictor was ACS‐associated AKI and outcomes early (30 day or in‐hospital) mortality and late‐mortality (post‐hospital discharge).
Results
Thirty‐six studies with 37 unique cohorts comprising 100 476 patients were included. The pooled rate of ACS‐associated AKI was 15.8%. In 32 cohorts reporting early mortality, the crude early mortality rate was 15.0% amongst those with AKI compared with 2.0% amongst those without AKI. The pooled estimate of the relative risk of AKI‐associated early mortality was 4.1 (95% confidence interval: 3.3 to 5.0) with high heterogeneity between studies (I
2
= 84% (61% to 88%)). When heterogeneity was accounted for mathematically using credibility ceilings, the risk of mortality was lower, but still clinically significant (3.1 (2.6 to 3.6)). In 19 cohorts reporting late mortality (1 to 10 years), the relative risk of AKI‐associated mortality was 2.6 (2.0 to 3.3) with moderate heterogeneity (I
2
= 65 % 35% to 88%). Following application of credibility ceiling relative risk estimate dropped to 2.2 (1.9 to 2.6).
Conclusions
Acute coronary syndrome‐associated AKI is associated with more than a three‐fold increase in early mortality and more than two‐fold in long‐term mortality.
Summary at a Glance
This meta‐analysis examines the impact of acute kidney injury on mortality risk in subjects with acute coronary syndrome and finds that short and long term mortality are increased 2–3 fold. This builds upon the literature showing the impact of AKI on outcomes in a variety of situations.
Marine natural products Blunt, John W; Copp, Brent R; Keyzers, Robert A ...
Natural product reports,
02/2012, Letnik:
29, Številka:
2
Journal Article
Recenzirano
Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to ...December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
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