Transforming growth factor β3 (TGF-β3) is an important mediator of growth, maintenance, and repair processes in human cells.
Internal dynamic properties have been derived from 15 N NMR relaxation ...data and mapped onto the spatial structure of TGF-β3. The pattern of internal dynamics in the structure identifies
potential âhot spotsâ of binding free energy and reveals the importance of conformational entropy in the interaction of TGF-β3
with the receptors. The observed internal dynamics set TGF-β3 apart from other TGF-β isoforms, with which it shares the same
fold. These findings may explain functional differences among the various TGF-β isoforms and thus prove essential in the search
for related therapeutic agents.
Transforming growth factor beta3 (TGF-beta3) is an important mediator of growth, maintenance, and repair processes in human cells. Internal dynamic properties have been derived from (15)N NMR ...relaxation data and mapped onto the spatial structure of TGF-beta3. The pattern of internal dynamics in the structure identifies potential "hot spots" of binding free energy and reveals the importance of conformational entropy in the interaction of TGF-beta3 with the receptors. The observed internal dynamics set TGF-beta3 apart from other TGF-beta isoforms, with which it shares the same fold. These findings may explain functional differences among the various TGF-beta isoforms and thus prove essential in the search for related therapeutic agents.
Using a Gibbs energy minimization method, a computer-assisted thermodynamic simulation of the MgO - C - H2O - air system at 298 - 2400 K is carried out to gain an insight into the behavior of a ...carbonized periclase material under operating conditions. The effect of temperature and the ambient gas medium on phase and chemical transformations in the bulk and pore space of the composite is studied.PUBLICATION ABSTRACT
The results of an experiment on the production of the
178
m
2
Hf isotope by exposing a natural mixture of hafnium isotopes to an intense bremsstrahlung beam are reported. The sample under ...investigation was exposed to an electron beam with an energy of 30 MeV and current 200 μ A for 500 h. The spectrometric analysis of the irradiated sample using radiochemical methods for the separation of isotopes did not reveal
178
m
2
Hf lines.
The backbone dynamics of the channel‐forming peptide antibiotic zervamicin IIB (Zrv‐IIB) in methanol were studied by
15
N nuclear magnetic resonance relaxation measurements at 11.7, 14.1 and 18.8 T ...magnetic fields. The anisotropic overall rotation of the peptide was characterized based on
15
N relaxation data and by hydrodynamic calculations. ‘Model‐free’ analysis of the relaxation data showed that the peptide is fairly rigid on a sub‐nanosecond time‐scale. The residues from the polar side of Zrv‐IIB helix are involved in micro–millisecond time‐scale conformational exchange. The conformational exchange observed might indicate intramolecular processes or specific intermolecular interactions of potential relevance to Zrv‐IIB ion channel formation.
Microwave dosimeters for domestic use Simakov, A.; Onishchenko, E.; Gurkovskiy, B. ...
2017 IEEE Workshop on Environmental, Energy, and Structural Monitoring Systems (EESMS),
2017-July
Conference Proceeding
Nowadays the growing microwave environmental contamination including home space can become a real challenge to all the residents. We present new portable devices, which provide a continuous remote ...monitoring of the microwave home background. These three different designs allow monitoring four main human microwave safety characteristics: SA - specific absorbed energy; MPE - maximum permissible exposure; SAR - specific absorption rate, and PD - power density. One may set a specific alarm level to match it with individual microwave sensitivity for personal precaution. New microwave dosimeters may work in professional, occupational and personal modes in smart home applications.
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